Imatinib associated acute pancreatitis: A rare case

Öz

Drug associated acute pancreatitis is uncommon entity but may arise with high morbidity and mortality. Pancreatitis due to imatinib use is rarely seen in the literature. A 70-year old female patient presented to our clinic with typical abdominal pain for of acute pancreatitis, 3 times higher amylase and lipase values than the upper limits. She had been receiving imatinib treatment for two years for gastrointestinal stromal tumor (GIST). Our case who had no other reason to explain the development of acute pancreatitis is presented because of the rare occurence of pancreatitis due to imatinib use in the literature.

Anahtar Kelimeler

• Acute pancreatitis,gastrointestinal stromal tumors,imatinib mesylate

İmatinib ilişkili akut pankreatit: Nadir görülen bir olgu

Öz

İlaç ilişkili akut pankreatit nadir görülmekle birlikte yüksek morbitite ve mortaliteyle seyredebilir. Literatürde İmatinib kullanımına bağlı gelişen pankreatit olgusuna çok az rastlanmaktadır. Kuşak tarzında akut pankreatit için tipik karın ağrısı, normal üst sınırlardan üç kat yüksek amilaz ve lipaz değerleriyle kliniğimize başvuran yetmiş yaşındaki kadın hasta, gastrointestinal stromal tümör (GİST) nedeniyle iki yıldır imatinib tedavisi almaktaydı. Akut pankreatit gelişimini açıklayacak başka bir neden saptanmayan olgumuz, literatürde İmatinib kullanımına bağlı pankreatite çok ender rastlanması nedeniyle sunulmuştur. 

Anahtar Kelimeler

• Akut pankreatit,gastrointestinal stromal tümörler,imatinib mesylate

Kaynakça

1. Referanslar:1. Yanada M, Takeuchi J, Sugiura I, Akiyama H, Usui N, Yagasaki F, et al. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: A phase II study by the Japan Adult Leukemia Study Group. J Clin Oncol. 2006;24:460–6. [PubMed]2. Greenberger NJ, Toskes PP. Acute and chronic pancreatitis. Harrison's Online. Available from:http://www.accessmedicine.com. [accessed on 2006 May 31]3. Chari ST, Vege SS. Etiology of acute pancreatitis. Up-to-date. Available from: http://www.uptodate.com. [accessed on 2006 May 31]4. Hunter TB, Bjelland JC. Gastrointestinal complications of leukemia and its treatment. AJR Am J Roentgenol. 1984;142:513–8. [PubMed]5. Eland IA, van Puijenbroek EP, Sturkenboom MJ, Wilson JH, Stricker BH. Drug-associated acute pancreatitis: Twenty-one years of spontaneous reporting in The Netherlands. Am J Gastroenterol. 1999;94:2417–22. [PubMed]