Yaşa bağlı gelişen bozukluklarda polifenoller ve hedefleri; mTOR sinyal ileti yolu

Öz

Dünya çapında, yaşa bağlı hastalıkların insidansının artmasıyla birlikte mortalite ve morbiditenin de yüksek olması yaşlanmayı yavaşlatan veya geciktiren müdahalelerin geliştirilmesine neden olmaktadır. Son yıllarda yaşa bağlı gelişebilecek bozukluklarla ilgili yapılan araştırmalar mTOR sinyal ileti yolu üzerinde yoğunlaşmıştır. mTOR ve yapısına dahil olduğu kompleksler yaşlanma ile ilişkilendirilen en önemli hücresel sinyal ileti yolu molekülleri olarak kabul edilmektedir. Ayrıca, mTOR inhibitörleri ile ilgili yaşlanma sürecini yavaşlatabildiklerine dair bulguların ortaya çıkması bu konu üzerindeki ilgiyi giderek arttırmaktadır. Bu derlemede, yaşa bağlı gelişebilecek bozukluklarda mTOR sinyal ileti yolunu hedefleyen diyet türevi doğal polifenolik bileşiklerle ilgili güncel bilgiler derlenmiştir. Ayrıca, polifenollerin yaşa bağlı bozukluklarının moleküler patojenezi üzerindeki etkilerinden de bahsedilmiştir.

Anahtar Kelimeler

• Yaşlanma,yaşa bağlı bozukluklar,polifenoller,mTOR

Polyphenols and targets in age-related disorders; mTOR signalling pathway

Öz

With the increase in the incidence of age-related diseases worldwide, the high mortality and morbidity cause the development of interventions that slow down or delay aging. In recent years, studies related to age-related disorders have been focused on the mTOR signalling pathway. mTOR and the complexes that mTOR involved in its structure are considered the most important cellular signalling pathway molecules associated with aging. In addition, the emergence of evidence that mTOR inhibitors can slow down the aging process is gradually increasing interest in this issue. In this review, current knowledge about diet-derived natural polyphenolic compounds targeting mTOR signal transduction pathways has been reviewed. Also, the effects of polyphenols on the molecular pathogenesis of age-related disorders have also been discussed.

Anahtar Kelimeler

• Aging,age-related disorders,polyphenols,mTOR

Kaynakça

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