Investigation of ischemia modified albumin levels in patients with lower limb ischemia

Öz

Aim: Acute limb ischemia occurs after the embolism or thrombosis and if it is not treated it may result in limb loss and even death. In addition, late diagnosis eliminates the chance of immediate intervention. Therefore, early diagnosis is crucial. It has been reported that ischemic modified albumin levels are known to be increased in acute ischemic conditions such as myocardial, cerebral and pulmonary infarctions. The aims of this study were to determine the levels of ischemic modified albumin in lower limb ischemia and to investigate its usability as an auxiliary parameter for early diagnosis. Materials and Methods: 24 patients (5 females, 19 males) with lower limb ischemia (patient group: 23-89 years old), 34 healthy individuals composed of 19 females and 15 males (control group; 20-75 years old) who were totally 58 cases were included in the study. The ischemic modified albumin levels in the serum samples obtained from individuals in the patient and control groups who met the inclusion criteria, were analyzed with the ELISA kit (Organo Teknika, Austria) in line with the manufacturer's instructions. Mann Whitney U test was used to compare ischemic modified albumin levels between groups. Results: It was found that patients with limb ischemia had a significantly increased ischemic modified albumin level compared to the control group (p <0.001). It was detected that the sensitivity value was 91.7 and the specificity value was 82.4 in the ROC curve analysis. Conclusion: We think that the significant increase in serum ischemic modified albumin levels in lower limb ischemia may be useful in the diagnosis of limb ischemia.

Anahtar Kelimeler

• Ischemia
• limb ischemia
• ischemia modified albumin
• early diagnosis

Alt ekstremite iskemisi olan hastalarda iskemi modifiye albümin düzeylerinin araştırılması

Öz

Amaç: Akut ekstremite iskemisi, emboli ya da tromboz akabinde ortaya çıkmakta ve tedavi edilmezse ekstremite kaybı ve hatta ölümle sonuçlanabilmektedir. Ayrıca, tanının gecikmesi acil girişim şansını ortadan kaldırmaktadır. Bu nedenle, erken tanı büyük önem taşımaktadır. Miyokard enfarktüsü, serebral infarkt ve pulmoner infarkt gibi akut iskemik durumlarda düzeylerinin yükseldiği bildirilen iskemi modifiye albüminin, iskemik durumlarda tanı belirteci olabileceği bildirilmektedir. Bu çalışmanın amacı da alt ekstremite iskemisinde iskemi modifiye albüm düzeyini belirlemek ve erken tanıya yardımcı bir parametre olarak kullanılabilirliğini araştırmaktır. Yöntem: Bu çalışmaya alt ekstremite iskemisi olan 5’i kadın, 19’u erkekten oluşan 24 hasta (hasta grubu; 23-89 yaş) ve kontrol amaçlı gelen 19’u kadın, 15’i erkekten oluşan 34 sağlıklı gönüllü (kontrol gurubu; 20-75 yaş) olmak üzere 58 kişi dahil edildi. Dahil edilme kriterlerine uygun hasta ve kontrol gruplarındaki bireylerden elde edilen serum örneklerindeki iskemi modifiye albüm düzeyleri, ELİSA kiti (Organo Teknika, Avusturya) ile analiz edildi. Gruplar arası iskemi modifiye albüm düzeylerinin karşılaştırılmasında Mann Whitney U testi kullanıldı. Bulgular: Akut ekstremite iskemisi olan hastalarda, kontrol grubundakiler ile karşılaştırıldığında önemli ölçüde artmış iskemi modifiye albüm düzeyi olduğu tespit edildi (p <0.001). ROC eğrisi analizinde sensitivite değeri 91.7 ve spesifite değeri 82.4 olarak tespit edildi. Sonuç: Alt ekstremite iskemisinde serum iskemi modifiye albüm düzeylerinde görülen önemli artışın, ekstremite iskemisinin tanısında yararlı olabileceğini düşünmekteyiz.

Anahtar Kelimeler

• İskemi
• Ekstremite iskemisi
• İskemi modifiye albumin
• Erken tanı

Kaynakça

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