Bisfenol A (BFA) ve insan üreme sağlığı

Yıl 2018, Cilt: 11 Sayı: 1, 86 - 99, 15.04.2018

Saniye Sözlü , Yasemin Akdevelioğlu

https://doi.org/10.26559/mersinsbd.330432

Cited By: 1

Öz

Bugün yaşantımızın her anında yer alan plastikler neredeyse
tüm ürünlerin içerisinde bulunmaktadır. Plastik üretiminde yaygın bir şekilde
kullanılan Bisfenol A (BFA), östrojeni taklit ederek endokrin bozucu gibi
davranıp insan üreme sağlığı üzerinde olumsuz etkilere yol açmaktadır. Bu
çalışma, BFA’nın üreme sağlığına olan potansiyel etkisini Pubmed veri tabanı
kullanılarak bugüne kadar yayınlanan insan temelli çalışmaları inceleyip
değerlendirmek amacıyla yapılmıştır. İncelenen literatür sonucunda BFA maruziyetinin
ovaryan cevapta, in vitro fertilizasyon (IVF) ve fertilizasyon başarısında
azalma, embriyo kalitesi ve sperm kalitesinde düşme, cinsiyet hormon
konsantrasyonlarında değişme, erkek cinsel işlev bozukluğu, polikistik over
sendromu (PCOS) ile ilişkili olabileceğini göstermektedir. Çalışmaların
sonuçları değerlendirildiğinde, BFA maruziyetinin azaltılması (hazır ambalajlı
ürünler, plastik kaplar vb. kullanımının azaltılması gibi) hastalıkların
önlenmesinde koruyucu bir faktör olabilir. İnsan üreme sağlığı üzerindeki etki
mekanizmalarını daha iyi anlamak ve erken aşamalardaki potansiyel üreme
toksisitesini tespit etmek için ileri çalışmalara ihtiyaç vardır. 

Anahtar Kelimeler

Endokrin bozucu, Bisfenol A, üreme sağlığı, infertilite

Kaynakça

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