Effect of Intravenous Adipose Tissue-Derived Mesenchymal Stem Cell Administration on Glycemic Index in a Cat with Diabetes Mellitus

Öz

Diabetes mellitus is caused by the defect of the insulin mechanism and characterised by hyperglycemia. Diabetes mellitus is a common disease in humans and is seen in dogs and cats. The disease pathophysiology is the same as that of humans. For this reason, diabetes mellitus in dogs and cats is classified according to medical literature. There is not a certain treatment method for diabetes mellitus. Management of the disease is based on keeping blood glucose within normal limits. Different methods are applied to keep the glycemic index between reference parameters. In recent years, it has been reported that stem cell applications have the ability to regenerate pancreatic beta cells and that stem cell applications can be used in diabetes mellitus cases. Adipose tissue-derived mesenchymal stem cells are used in veterinary medicine as safe and non-complicated applications. When studies on humans and stem cells accessible in veterinary medicine are evaluated, adipose tissue-derived mesenchymal stem cells come to the fore in cases of diabetes. In this case report, we avaluated the results of stem cell application along with insulin and diet in controlling the glycemic index in a cat diagnosed with diabetes. In this case, no side effects were observed, and similar results were obtained with studies conducted on insulin and diet. As a result of this case, the existence of a larger number of patients was emphasized, and the potential reported features of stem cell applications in diabetes cases were emphasized.

Anahtar Kelimeler

• Diabetes Mellitus
• Cat
• Mezenşimal
• Stem Cells

Diabetes Mellituslu Bir Kedide ntravenöz Yağ Doku Kökenli Mezenşimal Kök Hücre Uygulamasının Glisemik İndeks Üzerine Olan Etkisi

Öz

Diabetes mellitus, hiperglisemi ile seyreden, organizmadaki insulin mekanizmasının fonksiyon kaybından kaynaklanan bir hastalıktır. İnsanlarda yoğun olarak görüldüğü gibi kedi ve köpeklerde de görülmektedir. Patofizyolojisi insanlardakine benzemektedir. Bu sebeple kedi ve köpeklerdeki diabet olguları insanlardakine benzer şekilde sınıflandırılır. Diabetin kesin bir tedavisi bulunmamaktadır. Hastalığın yönetimi kan glukoz düzeyinin normal sınırlarda tutulmasına dayalıdır. Glisemik endeksi normal sınırlarda tutabilmek için farklı metotlar uygulanmaktadır. Son yıllarda yapılan çalışmalarda, kök hücre uygulamalarının bu yönde kullanılabileceği ve kök hücre uygulamalarının pankreas beta hücreleri üzerinde rejenerasyon kabiliyetinin olduğu bildirilmektedir. Yağ doku kökenli mezenşimal kök hücreler veteriner hekimlikte güvenli ve komplikasyona neden olmayan uygulamalar olarak yer almaktadır. İnsanlarda yapılan çalışmalar ve veteriner hekimlikte ulaşılabilen kök hücreler değerlendirildiğinde yağ doku kökenli mezenşimal kök hücreler diabet olgularında öne çıkmaktadır. Bu olgu sunumunda diabet tanısı koyulmuş bir kedide, glisemik indeksin kontrol altına alınmasında; insulin ve diyetin yanında kök hücre uygulamasının sonuçları değerlendirilmiştir. Bu vakada herhangi bir yan etki görülmediği gibi insulin ve diyet uygulanarak yapılan çalışmalar ile benzer sonuçlar elde edilmiştir. Bu klinik vaka çalışması sonucunda daha kapsamlı araştırmaların gerekliliği vurgulanarak, kök hücre uygulamalarının diabet olgularında potansiyel faydalar taşıdığı kanaatine varılmıştır.

Anahtar Kelimeler

• Diabetes Mellitus
• Kedi
• Mezenşimal
• Kök Hücre

Kaynakça

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