Scottish Fold Irkı Yavru Bir Kedide Mitral Kapak Stenozu ve Hipertrofik Kardiyomiyopati İlişkisi

Öz

Hipertrofik kardiyomiyopati (HCM), sol ventrikül hipertrofisi ile karakterize, kedilerde yaygın görülen bir kalp hastalığıdır. Mitral kapak stenozu ise diyastol sırasında sol atriyumdan (LA) sol ventriküle kan akışının kısmen engellenmesiyle karakterize, küçük hayvanlarda oldukça nadir görülen bir durumdur. Sekiz aylık Scottish Fold cinsi bir kedi, dispne şikâyeti ile Selçuk Üniversitesi Hayvan Hastanesi’ne getirildi. Fizik muayenede taşipne, dispne ve 3/6 şiddetinde sistolik üfürüm tespit edildi. Transtorasik ekokardiyografide sol ventrikül duvar kalınlığında artış ve LA dilatasyonu saptandı. İki boyutlu ekokardiyografik incelemede mitral kapakçıklarının tam olarak ayrılmadığı, mitral kapak orifis alanının daraldığı ve renkli Doppler incelemede mitral kapak seviyesinde belirgin diyastolik türbülans izlendi. Spektral Doppler analizi, mitral girişinde yüksek ortalama basınç gradiyenti ölçüldü. Bu bulgular, HCM ve mitral kapak stenozunun kedilerde bir arada bulunabileceğini ve ekokardiyografinin bu hastalıkların tanı ve değerlendirilmesinde yararlı bir araç olduğunu ortaya koymaktadır.

Anahtar Kelimeler

• Hipertrofik Kardiyomiyopati
• Kedi
• Mitral Kapak Stenozu

Etik Beyan

Bu araştırma çalışması araştırma ve yayın etiğine uygundur. MJAVL'de yayınlanan makalelerin bilimsel ve yasal sorumluluğu yazarlara aittir.

Association of Mitral Valve Stenosis and Hypertrophic Cardiomyopathy in a Scottish Fold Kitten

Öz

Hypertrophic cardiomyopathy (HCM) is a common feline heart disease characterized by left ventricular hypertrophy. Mitral valve stenosis is an extremely rare heart disease in small animals that causes partial obstruction of blood flow from the left atrium (LA) to the left ventricle during diastole. An eight-month-old Scottish Fold cat was brought to Selcuk University Animal Hospital with a complaint of dyspnea. Physical examination revealed tachypnea, dyspnea, and a grade 3/6 systolic murmur. Transthoracic echocardiography showed increased left ventricular wall thickness and LA dilation. Two-dimensional echocardiography revealed incompletely separated mitral valve leaflets, a narrowed mitral valve orifice area, and marked diastolic turbulence at the mitral valve level on color Doppler. Spectral Doppler demonstrated a high mean pressure gradient across the mitral valve inflow. These findings suggest that mitral valve stenosis and hypertrophic cardiomyopathy can coexist in cats and that echocardiography is a valuable diagnostic and evaluative tool for this condition.

Anahtar Kelimeler

• Cat
• Hypertrophic cardiomyopathy
• Mitral valve stenosis

Etik Beyan

This research study complies with research and publishing ethics. The scientific and legal responsibility for manuscripts published in MJAVL belongs to the authors.

Kaynakça

1. Boyden, P. A., Tilley, L. P., Pham, T. D., Liu, S. K., Fenoglio Jr, J. J., & Wit, A. L. (1982). Effects of left atrial enlargement on atrial transmembrane potentials and structure in dogs with mitral valve fibrosis. The American journal of cardiology, 49(8), 1896-1908.
2. Calafiore, A. M., Totaro, A., Testa, N., Sacra, C., Castellano, G., Guarracini, S., ... & Di Mauro, M. (2021). The secret life of the mitral valve. Journal of Cardiac Surgery, 36(1), 247-259.
3. Campbell, F. E., & Thomas, W. P. (2012). Congenital supravalvular mitral stenosis in 14 cats. Journal of Veterinary Cardiology, 14(1), 281-292.
4. Carabello, B. A. (2005). Modern management of mitral stenosis. Circulation, 112(3), 432-437.
5. Carpenito, M., Fanti, D., Mega, S., Benfari, G., Bono, M. C., Rossi, A., ... & Grigioni, F. (2021). The central role of left atrium in heart failure. Frontiers in Cardiovascular Medicine, 8, 704762.
6. Cirino, A. L., & Ho, C. (2021). Hypertrophic cardiomyopathy overview.
7. Grzeczka, A., Graczyk, S., Pasławski, R., & Pasławska, U. (2024). Genetic Basis of Hypertrophic Cardiomyopathy in Cats. Current Issues in Molecular Biology, 46(8), 8752-8766.
8. Kittleson, M. D., & Côté, E. (2021). The feline cardiomyopathies: 2. Hypertrophic cardiomyopathy. Journal of feline medicine and surgery, 23(11), 1028-1051.

9. Lu, T. L., Hung, Y. W., Choi, R., & Hyun, C. (2016). Congenital mitral valve stenosis in a Chinchilla cat. Korean Journal of Veterinary Research, 56(3), 197-200.
10. Matsuu, A., Kanda, T., Sugiyama, A., Murase, T., & Hikasa, Y. (2007). Mitral stenosis with bacterial myocarditis in a cat. Journal of Veterinary Medical Science, 69(11), 1171-1174.
11. Meurs, K. M., Norgard, M. M., Ederer, M. M., Hendrix, K. P., & Kittleson, M. D. (2007). A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy. Genomics, 90(2), 261-264.
12. Meurs, K. M., Sanchez, X., David, R. M., Bowles, N. E., Towbin, J. A., Reiser, P. J., ... & Kittleson, M. D. (2005). A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy. Human molecular genetics, 14(23), 3587-3593.
13. Neema, P. K. (2015). Pathophysiology of mitral valve stenosis. MAMC Journal of Medical Sciences, 1(1), 25-27.
14. Novo Matos, J., Payne, J. R., Seo, J., & Luis Fuentes, V. (2022). Natural history of hypertrophic cardiomyopathy in cats from rehoming centers: The CatScan II study. Journal of Veterinary Internal Medicine, 36(6), 1900- 1912.
15. Payne, J. R., Brodbelt, D. C., & Fuentes, V. L. (2015). Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study). Journal of Veterinary Cardiology, 17, S244-S257.
16. Roberts, W. C., & Perloff, J. K. (1972). Mitral valvular disease: a clinicopathologic survey of the conditions causing the mitral valve to function abnormally. Annals of internal medicine, 77(6), 939-975.
17. Schipper, T., Van Poucke, M., Sonck, L., Smets, P., Ducatelle, R., Broeckx, B. J., & Peelman, L. J. (2019). A feline orthologue of the human MYH7 c. 5647G> A (p.(Glu1883Lys)) variant causes hypertrophic cardiomyopathy in a Domestic Shorthair cat. European journal of human genetics, 27(11), 1724-1730.
18. Schober, K. E., & Chetboul, V. (2015). Echocardiographic evaluation of left ventricular diastolic function in cats: hemodynamic determinants and pattern recognition. Journal of Veterinary Cardiology, 17, S102-S133.
19. Shah, S. N., Sharma, S., & Bossuah, K. A. (2023). Mitral Stenosis (Nursing). In StatPearls [Internet]. StatPearls Publishing.
20. Stamoulis, M. E., & Fox, P. R. (1993). Mitral valve stenosis in three cats. Journal of Small Animal Practice, 34(9), 452-456.
21. Takemura, N., Nakagawa, K., Machida, N., Washizu, M., Amasaki, H., & Hirose, H. (2003). Acquired mitral stenosis in a cat with hypertrophic cardiomyopathy. Journal of veterinary medical science, 65(11), 1265- 1267.
22. Thomas, W. P., Gaber, C. E., Jacobs, G. J., Kaplan, P. M., Lombard, C. W., Vet, M., ... & Moses, B. L. (1993). Recommendations for standards in transthoracic two‐dimensional echocardiography in the dog and cat. Journal of veterinary internal medicine, 7(4), 247-252.
23. Trehiou‐Sechi, E., Tissier, R., Gouni, V., Misbach, C., Petit, A. M. P., Balouka, D., ... & Chetboul, V. (2012). Comparative echocardiographic and clinical features of hypertrophic cardiomyopathy in 5 breeds of cats: a retrospective analysis of 344 cases (2001–2011). Journal of Veterinary Internal Medicine, 26(3), 532-541.
24. Waller, B. F. (1986). Rheumatic and nonrheumatic conditions producing valvular heart disease. Cardiovascular clinics, 16(2), 3-104.
25. Ware WA, Ward JL, 2020. Congenital cardiac disease, In: Small Animal Internal Medicine, Ed; Nelson RW, Couto CG, Sıxth edition Elsevier, St. Louis, Missouri, pp; 100-117.