Evaluation of Vitamin D Levels in Fibromyalgia Patients and the Relation to Functional Status

Öz

Aim: Fibromyalgia syndrome is a common musculoskeletal disorder, characterized by chronic widespread pain, multiple tender points, joint stiffness, and systemic symptoms without any underlying organic disease. The initial aim of the present study was to determine the vitamin D levels in patients with fibromyalgia and compare these values to those found in healthy subjects. Then, correlations between functional status, clinical severity of the disease, and vitamin D levels were assessed. Material and Methods: This case-control study included 137 female fibromyalgia patients and 109 healthy female counterparts. The severity of pain was assessed by a visual analogue scale and the functional impact was evaluated through the Fibromyalgia Impact Questionnaire in the patient group. Vitamin D levels were compared between groups, and the correlation between vitamin D levels and questionnaire scores was determined. Results: Vitamin D and parathormone levels did not differ significantly between groups (p=0.858, p=0.790 respectively). The mean Fibromyalgia Impact Questionnaire scores and the medians for the visual analogue scale did not differ significantly among vitamin D deficient, insufficient, and sufficient patients (p=0.548 , p=0.952 respectively). In addition, no significant correlation between vitamin D levels and the Fibromyalgia Impact Questionnaire score was found(Spearman’s rho=0.056, p=0.513). Conclusion: This study did not show any significant differences between the vitamin D levels of fibromyalgia patients and those of healthy subjects. Further, in fibromyalgia patients, there was no correlation between vitamin D levels and functional status or disease severity

Anahtar Kelimeler

• Fibromyalgia
• vitamin D levels
• fibromyalgia impact questionnaire

Fibromiyaljili Hastalarda D Vitamin Düzeylerinin Değerlendirilmesi ve Fonksiyonel Durum ile İlişkisi

Öz

Amaç: Fibromiyalji sendromu, yaygın ağrı, çok sayıda hassas nokta, eklemlerde katılık ve herhangi bir organik bozukluğa bağlanamayan sistemik semptomlarla karakterize, sık görülen bir kas iskelet sistemi bozukluğudur. Bu çalışmayı yapmaktaki başlangıç amacımız, fibromiyalji hastalarında D vitamini düzeylerini belirlemek ve sağlıklı bireylerdeki ile karşılaştırmaktı. Sonrasında fonksiyonel durum ve hastalık şiddeti ile D vitamin düzeyleri arasındaki bağıntıyı değerlendirdik. Gereç ve Yöntemler: Bu vaka-kontrol çalışmasında, 137 kadın fibromiyalji hastası ve 109 sağlıklı kadın birey karşılaştırıldı. Hasta grubunda ağrı şiddetini değerlendirmek için görsel analog skala ve fonksiyonel durumu değerlendirmek için “Fibromiyalji etki anketi” kullanıldı. Her iki gruba ait D vitamini düzeyleri karşılaştırıldı. Fibromiyaljili hastalarda D vitamini düzeyleri ile “Fibromiyalji etki anketi” skoru arasındaki bağıntı değerlendirildi. Bulgular: Gruplar arasında D vitamini ve parathormon düzeyleri bakımından anlamlı derecede fark yoktu(Sırasıyla p=0.858 , p=0.790). Hastalarda, ortalama “Fibromiyalji etki anketi” skoru ve ortanca görsel analog skala değeri, D vitamini düzeyinin eksik, yetersiz veya yeterli olması durumuna bağlı olarak anlamlı derecede bir değişim göstermedi(Sırasıyla p=0.548 , p=0.952). D vitamini düzeyleri ile “Fibromiyalji etki anketi” skoru arasında anlamlı bir ilişki izlenmedi(Spearman’s rho=0.056, p=0.513). Sonuç: Bu çalışmada fibromiyaljili hastalar ile sağlıklı bireyler arasında D vitamini düzeyleri bakımından anlamlı bir fark görülmedi. Fibromiyalji hastalarında D vitamini düzeyleri ile fonksiyonel durum ve hastalık şiddeti arasında anlamlı bir bağıntı yoktu.

Anahtar Kelimeler

• Fibromiyalji
• D vitamin düzeyi
• Fibromiyalji etki anketi

Kaynakça

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