Role of Eosinophil Count and Percentage in Chronic Obstructive Pulmonary Disease Exacerbation: A Retrospective Observational Study

Öz

Aim: To reveal the role of eosinophil count and percentage evaluated at the time of presentation in patients hospitalized with the exacerbation of chronic obstructive pulmonary disease (COPD). Material and Methods: In this study, the data of patients with a diagnosis of the exacerbation of COPD, who presented to the emergency department, and admitted to the general internal medicine ward, were retrospectively analyzed. The relationship of eosinophil count and ratios with the length of hospital stay and intensive care requirement was investigated.The Spearman correlation analysis was used for investigating correlation between parameters and outcome. Results: Of the study population, 39.7% were female and 60.3% were male. The ages of the participants ranged from 25 to 94 years, with a median value of 76 years. There was no significant correlation between the length of stay in ward and eosinophil count and percentage (rho=-0.148, p=0.066 and p=0.074, rho=-0.143, respectively) (Spearman correlation test). The group admitted to the intensive care unit had a significantly higher eosinophil count and percentage of eosinophils than the group that did not require intensive care (0.81(Inter Quarter Range (IQR):0.41-1.31) versus 1.32 (IQR:0.83-1.43) p=0.042 and 1.0 (IQR:0.81-1.21) versus 1.42 (IQR:1.02-1.64), p=0.018, respectively) (Mann Whitney U test). Conclusion: There was no correlation between a high eosinophil count and percentage and the length of hospital stay. However, the number and percentage of eosinophils were significantly higher among the patients requiring intensive care.

Anahtar Kelimeler

• chronic obstructive pulmonary disease
• length of hospital stay
• eosinophil
• hospitalization
• intensive care unit

Kronik Obstrüktif Akciğer Hastalığı Alevlenmesinde Eozinofil Sayısı ve Yüzdesinin Rolü: Bir Gözlemsel Retrospektif Çalışma

Öz

Amaç: Kronik obstrüktif akciğer hastalığı (KOAH) alevlenmesi ile hastaneye yatırılan hastalarda başvuru anında değerlendirilen eozinofil sayısı ve yüzdesinin rolünü ortaya çıkarmak. Gereç ve Yöntemler: Bu çalışmada, acil servise başvuran ve genel dahiliye servisine yatırılan KOAH alevlenmesi olan 156 hastanın verileri geriye dönük olarak incelendi. Eozinofil sayısı ve oranlarının hastanede kalış süresi ve yoğun bakım gereksinimi ile ilişkisi araştırıldı. Spearman korelasyon testi ile sonlanım ile parametreler arası korelasyon araştırıldı. Bulgular: Çalışma popülasyonunun, %39,7’si kadın ve %60,3’ü erkek idi. Olguların yaşları 25 ile 94 arasında değişmekte olup, medyan değeri 76 idi. Serviste kalış süresi ile eozinofil sayısı ve yüzdesi arasında anlamlı bir ilişki yoktu (sırasıyla rho=-0,148, p=0,066 ve p=0,074, rho=-0,143) (Spearman korelasyon testi). Yoğun bakım ünitesine kabul edilen grup, yoğun bakım gerektirmeyen gruba göre önemli ölçüde daha yüksek eozinofil sayısına ve eozinofil yüzdesine sahipti (0,81(Çeyrekler arası aralık (ÇAA):0,41-1,31)’ e karşı 1,32 (ÇAA:0,83-1,43) p=0,042 ve 1,0 (ÇAA:0,81-1,21)’e karşı 1,42 (ÇAA:1,02-1,64), p=0,018, sırasıyla). Sonuç: Yüksek eozinofil sayısı ve yüzdesi ile hastanede kalış süresi arasında ilişki yoktu. Ancak yoğun bakıma ihtiyacı olan hastalarda eozinofil sayısı ve yüzdesi anlamlı olarak daha yüksekti.

Anahtar Kelimeler

• kronik obstrüktif akciğer hastalığı
• hastanede kalış süresi
• eozinofil
• yoğun bakım ünitesi
• hastaneye yatış

Kaynakça

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