Complement System and Disorders

Yıl 2023, Cilt: 7 Sayı: 2, 103 - 111, 31.08.2023

Öner Özdemir

https://doi.org/10.29058/mjwbs.1250481

Öz

The complement system is a part of the immune system that has been known for a long time, and
it needs to be reviewed in the light of new literature data that has increased in recent years. Firstly,
complement system biology and functions of complement elements will be discussed. The mechanism
of the three known pathways of this system and the regulatory proteins of this system will be explained.
After defining the complement disorders, their frequency in the community, and how we recognize in the
clinic setting, some of the complement diseases that have been known for a long time and the diseases
have just learned will be mentioned. Finally, we will discuss laboratory tests of complement diseases.

Anahtar Kelimeler

Immunodeficiency , complement , AH50 , CH50 , properdin , MBL

Proje Numarası

yok

Kompleman Sistemi ve Hastalıkları

Öz

Kompleman sistemi immün sistemin çok eskiden beri bilinen bir parçası olup, son yıllarda artan yeni
literatür verileri ışığında gözden geçirilmesine ihtiyaç vardır. İlk olarak, kompleman sistem biyolojisi
ve kompleman elementlerinin işlevlerinden bahsedilecektir. Bu sisteme ait bilinen 3 yolağın işleme
mekanizması ve bu sistemin regülatör proteinleri anlatılacaktır. Kompleman hastalıklarının tanımı,
toplumdaki sıklığı, nasıl klinikte tanınabileceklerinden bahsedildikten sonra, eskiden beri bilinen
ve yeni yeni öğrendiğimiz bazı kompleman hastalıklardan bahsedilecektir. Son olarak, kompleman
hastalıklarının laboratuvar testlerinden bahsedilecektir.

Anahtar Kelimeler

İmmünyetmezlik , kompleman , AH50 , CH50 , properdin , MBL

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

yok

Kaynakça

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