Complement System and Disorders

Öz

The complement system is a part of the immune system that has been known for a long time, and it needs to be reviewed in the light of new literature data that has increased in recent years. Firstly, complement system biology and functions of complement elements will be discussed. The mechanism of the three known pathways of this system and the regulatory proteins of this system will be explained. After defining the complement disorders, their frequency in the community, and how we recognize in the clinic setting, some of the complement diseases that have been known for a long time and the diseases have just learned will be mentioned. Finally, we will discuss laboratory tests of complement diseases.

Anahtar Kelimeler

• Immunodeficiency
• complement
• AH50
• CH50
• properdin
• MBL

Kompleman Sistemi ve Hastalıkları

Öz

Kompleman sistemi immün sistemin çok eskiden beri bilinen bir parçası olup, son yıllarda artan yeni literatür verileri ışığında gözden geçirilmesine ihtiyaç vardır. İlk olarak, kompleman sistem biyolojisi ve kompleman elementlerinin işlevlerinden bahsedilecektir. Bu sisteme ait bilinen 3 yolağın işleme mekanizması ve bu sistemin regülatör proteinleri anlatılacaktır. Kompleman hastalıklarının tanımı, toplumdaki sıklığı, nasıl klinikte tanınabileceklerinden bahsedildikten sonra, eskiden beri bilinen ve yeni yeni öğrendiğimiz bazı kompleman hastalıklardan bahsedilecektir. Son olarak, kompleman hastalıklarının laboratuvar testlerinden bahsedilecektir.

Anahtar Kelimeler

• İmmünyetmezlik
• kompleman
• AH50
• CH50
• properdin
• MBL

Kaynakça

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