The Effect of Halp Score on the Development of Pharyngocutaneous Fistula After Laryngectomy

Öz

Aim: Laryngeal cancers are prominent among head and neck cancers, and laryngectomy is commonly performed in advanced cases. Pharyngocutaneous fistula (PCF), a postoperative complication, negatively impacts quality of life, prolongs hospitalization, and delays treatment. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score, calculated from hemoglobin, albumin, lymphocyte, and platelet levels, reflects immune and nutritional status. Material and Methods: This retrospective study included 76 patients who underwent surgery for laryngeal cancer between January 2012 and June 2024. Patients were grouped based on partial or total laryngectomy, and HALP scores were compared with the incidence of fistula. Results: In the total laryngectomy group, the mean HALP score was 33.42±17.17 for patients without fistula and 42.79±30.00 for those with fistula. No statistically significant difference was found between the two groups (p>0.05). Conclusion: No significant relationship was found between HALP score and PCF development. However, since hemoglobin and albumin may be risk factors, larger, multicenter prospective studies are needed for a more comprehensive evaluation

Anahtar Kelimeler

• HALP score
• laryngectomy
• pharyngocutaneous fistula

Larenjektomi Sonrası Faringokutanöz Fistül Gelişimi Üzerine Halp Skoru Etkisi

Öz

Amaç: Larengeal kanserler, baş ve boyun kanserleri içinde önemli bir yer tutar ve ileri evre hastalarda genellikle larenjektomi uygulanır. Cerrahiden sonra gelişebilen farengokütanöz fistül (FKF), yaşam kalitesini düşürür, hastanede kalış süresini uzatır ve tedavi sürecini aksatır. Hemoglobin, Albumin, Lenfosit ve Platelet (HALP) skoru; hemoglobin, albümin, lenfosit ve trombosit parametrelerinin kullanıldığı, immün ve beslenme durumunu yansıtan bir biyomarkerdir. Gereç ve Yöntemler: Ocak 2012 - Haziran 2024 tarihleri arasında kliniğimizde larenks kanseri nedeniyle opere edilen 76 hasta retrospektif olarak değerlendirildi. Hastalar, kısmi veya total larenjektomi geçirmelerine göre gruplandırıldı ve HALP skorları ile fistül gelişimi karşılaştırıldı. Bulgular: Total larenjektomi yapılan ve fistül gelişmeyen hastaların ortalama HALP skoru 33.42±17.17, fistül gelişenlerin ise 42.79±30.00 idi. Ancak gruplar arasında istatistiksel olarak anlamlı fark saptanmadı (p>0.05). Sonuç: HALP skoru ile FKF gelişimi arasında anlamlı bir ilişki bulunmadı. Ancak hemoglobin ve albümin düzeylerinin risk faktörü olabileceği göz önünde bulundurularak, bu ilişkiyi değerlendirmek için daha geniş, çok merkezli ve prospektif çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Faringokutanöz fistül
• HALP skoru
• larenjektomi

Kaynakça

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