Non-Alkolik Yağlı Karaciğer Hastalığı Olan Çocuklarda Lipid Profilleri ve D Vitamini Düzeylerinin Yağlı Karaciğer Derecesi Üzerindeki Etkileri

Öz

Amaç: Çalışmanın amacı hepatosteatoz hastalarının D vitamini, trigliserit ve kolesterol düzeylerini sağlıklı kontrol hastalarıyla karşılaştırmaktır. Gereç ve Yöntemler: Çalışmamıza retrospektif olarak hepatosteatozlu 99 hasta ve sağlıklı kontrol hastaları dahil edildi. Çalışmaya dahil edilen hastalar 2020-2023 yılları arasında çocuk gastroenteroloji polikliniğine başvuran hastalardı. Bulgular: Çalışmamıza hepatosteatozlu 47 (%47,5) ve kontrol grubunda 52 (%52,5) olmak üzere toplam 99 hasta dahil edildi. Ortalama ALT değerleri hepatosteatoz ve kontrol gruplarında sırasıyla 35,2 ± 19,5 ve 28,3 ± 13,0 idi (P= 0,039). Ortalama trigliserit (136 ± 28 vs 125 ± 24; P= 0.042) ve kolesterol (165 ± 20 vs 154 ± 20; P= 0.010) düzeyleri hepatosteatoz grubunda kontrol grubuna göre daha yüksekti ve sonuç anlamlı olarak farklı bulundu. Ortalama D vitamini düzeyleri gruplar arasında farklılık göstermedi. Her iki grupta da D vitamini eksikliği yüksek bulundu, ancak gruplar arasında fark analiz edilmedi (%72.3 vs %61.5; P= 0.491). Sonuç: Hepatosteatozlu hastalarda trigliserit ve kolesterol düzeyleri daha yüksek bulundu. Açlık kan şekeri hepatosteatoz grubunda daha yüksektir. Bu sonuçlara ve literatüre dayanarak, hepatosteatozlu hastalar ilerleyen yıllarda metabolik sendrom ve ateroskleroz gibi kardiyovasküler hastalıklar gibi önemli hastalıklar için risk oluşturmaktadır.

Anahtar Kelimeler

• Kolesterol
• hepatosteatoz
• trigliserid
• D vitamini

Effects of Lipid Profiles and Vitamin D Levels on the Degree of Fatty Liver in Children with Non-Alcoholic Fatty Liver Disease

Öz

Aim: The aim of the study was to compare vitamin D, triglyceride and cholesterol levels of hepatosteatosis patients with healthy control patients. Material and Methods: Ninety-nine patients with hepatosteatosis and healthy control patients were included in our study retrospectively. The patients included in the study were patients who applied to the pediatric gastroenterology outpatient clinic between 2020 and 2023. Results: A total of 99 patients, 47 (47.5%) with hepatosteatosis and 52 (52.5%) in the control group, were included in our study. Mean ALT values were 35.2 ± 19.5 and 28.3 ± 13.0 in the hepatosteatosis and control groups, respectively (P= 0.039). Mean triglyceride (136 ± 28 vs 125 ± 24; P= 0.042) and cholesterol (165 ± 20 vs 154 ± 20; P= 0.010) levels were higher in the hepatosteatosis group than in the control group and the result was found to be significantly different. Mean vitamin D levels did not differ between the groups. Vitamin D deficiency was found to be high in both groups, but no difference was analyzed between the groups (72.3% vs 61.5%; P= 0.491). Conclusion: Triglyceride and cholesterol levels were found to be higher in patients with hepatosteatosis. Fasting blood glucose is higher in the hepatosteatosis group. Based on these results and the literature, patients with hepatosteatosis pose a risk for important diseases such as metabolic syndrome and cardiovascular diseases such as atherosclerosis in the following years.

Anahtar Kelimeler

• Cholesterol
• hepatosteatosis
• triglyceride
• vitamin D

Kaynakça

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