Serebrovasküler hastalığı olan hastalarda bitkisel ve vitamin takviyesi kullanımı: Kesitsel bir çalışma

Öz

Amaç: Günümüzde tamamlayıcı tıp yöntemleri arasında bulunan herbal ürünler, konvansiyonel tedavi yanında popülerliğini korumaktadırlar. Tıbbi müdahale gören bireylerin herbal ürünlere başvurmaları, ilaç etkileşimleri ve istenmeyen yan etkiler açısından önemli klinik sonuçlar doğurabilmektedir. Özellikle serebrovasküler hastalık gibi kronik sağlık sorunlarında kullanım sıklığı ve potansiyel riskleri, bu çalışmada incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Kesitsel tipteki bu çalışmada, Haziran 2022-Aralık 2023 tarihleri arasında etik kurul onayı alınarak serebrovasküler hastalıklar polikliniğine başvuran 108 katılımcıdan dahil edilme/edilmeme kriterlerine uygun 91 katılımcıya yüz yüze görüşme yöntemi kullanılarak uygulanan anket ile bireylerin bitkisel ürünlere yönelik tutumları ve sosyodemografik özellikleri incelenmiştir. Katılımcıların bilgi güvenliği, anket katılımına yönelik olası önyargılar veya tedavi algoritmalarının değişebileceği endişesi nedeniyle yanıtlamak istemedikleri anket soruları boş bırakılmıştır. Bulgular: Çalışmaya katılanların cinsiyet dağılımı incelendiğinde, kadınların (n: 34, %39,5) erkeklerden (n:52, %60,5) daha az olduğu görülmüştür. Katılımcıların %27,5’i bitkisel ürün tüketimi olduğunu bildirmiştir. Cinsiyet ile bitkisel ürün kullanımı arasında istatistiksel olarak anlamlı bir ilişki tespit edilememiştir (p=0,248). Katılımcılar, bitkisel ürünleri çoğunlukla serebrovasküler hastalık ve semptomlarını yönetmek amacıyla kullandıklarını belirtmişlerdir. Ancak, katılımcıların sadece %36,3 (n:33) bitkisel ürünlerin potansiyel yan etkileri konusunda bilgi sahibi olduğunu ifade etmiştir. Sonuç: Araştırmamızda, katılımcıların %27,5'inin (n:25) bitkisel destek ürünleri kullandığı ve bunlar arasında en çok sarımsağın tercih edildiği saptanmıştır. Bitkisel ürün kullanımında cinsiyetin etkisi üzerine yapılan analizlerde istatistiksel olarak anlamlı bir farklılık bulunmamıştır (p=0,248). Hekimlerin, hastalarının tedavi ve takipleri sırasında bitkisel ilaç kullanabileceklerini akıllarında tutmaları önemlidir.

Anahtar Kelimeler

• Bitkisel ilaç
• bitki- ilaç etkileşimi
• prevelans
• serebrovasküler hastalık

Herbal and vitamin supplement use in patients with cerebrovascular disease: A cross-sectional study

Öz

Aim: Herbal products, which are among the complementary medicine methods today, maintain their popularity alongside conventional treatment. The use of herbal products by individuals undergoing medical intervention may have important clinical consequences in terms of drug interactions and undesirable side effects. The frequency of use and potential risks, especially in chronic health problems such as cerebrovascular disease, are aimed to be examined in this study. Material and Methods: In this cross-sectional study, the attitudes and sociodemographic characteristics of individuals towards herbal products were examined with a questionnaire applied using the face-to-face interview method to 91 participants who met the inclusion/exclusion criteria out of 108 participants who applied to the cerebrovascular diseases outpatient clinic with ethics committee approval between June 2022 and December 2023. Survey questions that participants did not want to respond due to concerns about information security, possible biases against survey participation or concerns that treatment algorithms might change were left blank.. Results: When the gender distribution of the participants was examined, it was seen that women (n: 34, 39.5%) were less than men (n:52, 60.5%). 27.5% of the participants reported that they consumed herbal products. No statistically significant relationship was found between gender and herbal product use (p=0.248). Participants stated that they mostly used herbal products to manage cerebrovascular disease and its symptoms. However, only 36.3% (n:33) of the participants stated that they were aware of the possible side effects of herbal products. Conclusion: In our study, it was determined that 27.5% (n:25) of the participants used herbal supplements and garlic was the most preferred among them. No statistically significant difference was found in the analyses conducted on the effect of gender on herbal product use (p=0.248). It is important for physicians to keep in mind that their patients may be using herbal medicine during their treatment and follow-up.

Anahtar Kelimeler

• Cerebrovascular disease
• herbal medicine
• herb-drug interaction
• prevalence

Kaynakça

1. Purroy F, Montalà N. Epidemiology of stroke in the last decade: a systematic review. Rev Neurol. 2021; 73: 321-36. https://doi.org/10.33588/rn.7309.2021138
2. Topcuoglu MA, Ozdemir AO. Acute stroke management in Turkey: Current situation and future projection. Eur Stroke J. 2023;8(1 Suppl):16-20. https://doi.org/10.1177/23969873221103943
3. Topcuoglu M. Stroke Epidemiology and Near Future Projection in Turkey: Analysis of Turkey Data from the Global Burden of Disease Study. Turkish Journal Of Neurology. 2022;28. https://doi.org/10.4274/tnd.2022.31384
4. Belagaje SR. Stroke Rehabilitation. Continuum (Minneap Minn). 2017;23(1, Cerebrovascular Disease):238-253. https://doi.org/10.1212/CON.0000000000000423
5. Sandlin D, Cpanthe RN. American Society of Anesthesiologists Addresses Herbal Medications. J Perianesth Nurs. 2001;16:201-3. https://doi.org/10.1053/jpan.2001.24274
6. İyilikçi L, Erden F, Baydar H, Tataroğlu AB, Güven Ö, Fazlic S, et al. Pediyatrik Olgularda Herbal İlaç Kullanımının Preanestezik Değerlendirmede Önemi. Journal of the Turkish Anaesthesiology-Intensive Care Society-JTAICS/Türk Anestezi ve Reanimasyon Dergisi. 2011;39(2).83-88. https://doi.org/10.5222/JTAICS.2011.083
7. Nural N, Çakmak S. Status of Using Complemantary and Alternative Treatments of Individuals with Chronic disease, J Tradit Complem Med 2018;1. 1-9. https://doi.org/10.5336/jtracom.2017-54818
8. Dong X, Zhang T, Zhang C, Shang W, Zhang Y, Zhang X. Traditional Chinese herbal medicines for the treatment of ischemic stroke in China. Ageing Res Rev. 2025;110:102803. https://doi.org/10.1016/j.arr.2025.102803.

9. Özduran E, Erkin Y, Hancı V, İyilikçi L, Gönüllü E, Tertemiz OF, Kara MM. Herbal Product/Drug Usage Habits of Patients Applying to the Pain Clinic. Ege Klinikleri Tıp Dergisi. 2023;61(2): 124-132.
10. İyilikçi L, Büyükçoban S, İnce İE, Kovalı M. Evaluation of Herbal Product Use and Preanaesthetic Questioning of Couples Undergoing In Vitro Fertilisation. Turk J Anaesthesiol Reanim. 2021;49(2):144-151. https://doi.org/10.5152/TJAR.2020.218
11. Swerdlow J. Heal NP, ed. Medicine changes: late 19th to early 20th century, Vol. 110-191, National Geographic Society, Washington, DC;2000.
12. Smith T, Kawa K, Eckl V, Johnson J. Sales of herbal dietarysupplements in US increased 7.5% in 2015 Consum-ers spent $6.92 billion on herbal supplements in 2015,marking the 12th consecutive year of growth. HerbalGram 2016;111:67-73
13. Salm S, Rutz J, van den Akker M, Blaheta RA, Bachmeier BE. Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments. Front Pharmacol. 2023;14:1234701. https://doi.org/10.3389/fphar.2023.1234701
14. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart Disease and Stroke StatisticsV2016 Update: a report from the American Heart Association. Circulation 2016;133(4):e38-360.. https://doi.org/10.1161/CIR.0000000000000350
15. Murphy SJ, Werring DJ. Stroke: causes and clinical features. Medicine (Abingdon). 2020;48(9):561-566. https://doi.org/10.1016/j.mpmed.2020.06.002
16. Gaire BP. Herbal Medicine in Ischemic Stroke: Challenges and Prospective. Chin J Integr Med. 2018;24(4):243-246. https://doi.org/10.1007/s11655-018-2828-2
17. Iriti M, Vitalini S, Fico G, Faoro F. Neuroprotective herbs and foods from different traditional medicines and diets. Molecules. 2010;15(5):3517-55. https://doi.org/10.3390/molecules15053517
18. Wu PF, Zhang Z, Wang F, Chen JG. Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury. Acta Pharmacol Sin. 2010;31(12):1523-1531. https://doi.org/10.1038/aps.2010.186
19. Rashrash M, Schommer JC, Brown LM. Prevalence and Predictors of Herbal Medicine Use Among Adults in the United States. J Patient Exp. 2017;4(3):108-113. https://doi.org/10.1177/2374373517706612
20. Han SY, Hong ZY, Xie YH, Zhao Y, Xu X. Therapeutic effect of Chinese herbal medicines for post stroke recovery: A traditional and network meta-analysis. Medicine (Baltimore). 2017;96(49):e8830. https://doi.org/10.1097/MD.0000000000008830
21. Zhu T, Wang L, Feng Y, Sun G, Sun X. Classical Active Ingredients and Extracts of Chinese Herbal Medicines: Pharmacokinetics, Pharmacodynamics, and Molecular Mechanisms for Ischemic Stroke. Oxid Med Cell Longev. 2021;2021:8868941. https://doi.org/10.1155/2021/8868941
22. Farooqui A, Farooqui T Garlic and its Effects in Neurological Disorders. Neuroprotective Effects of Phytochemicals in Neurological Disorders. 2017;10.1002/9781119155195.ch5. https://doi.org/10.1002/9781119155195.ch5
23. de Souza Silva JE, Santos Souza CA, da Silva TB, Gomes IA, Brito Gde C, de Souza Araújo AA, et al. Use of herbal medicines by elderly patients: A systematic review. Arch Gerontol Geriatr. 2014;59(2):227-33. https://doi.org/10.1016/j.archger.2014.06.002
24. Rasheed H, Ahmed S, Sharma A. Changing Trends Towards Herbal Supplements: An Insight into Safety and Herb-drug Interaction. Curr Pharm Biotechnol. 2024;25(3):285-300. https://doi.org/10.2174/1389201024666230718114606
25. Zaidi SF, Saeed SA, Khan MA, Khan A, Hazazi Y, Otayn M, et al. Public knowledge, attitudes, and practices towards herbal medicines; a cross-sectional study in Western Saudi Arabia. BMC Complement Med Ther. 2022;22(1):326. https://doi.org/10.1186/s12906-022-03783-y
26. Taher M, Ibrahim R. Knowledge, attitudes, and practice of university’s employees about complementary and alternative medicine (CAM). Informatics in Medicine Unlocked. 2023;37. 101184. https://doi.org/10.1016/j.imu.2023.101184
27. Raja R. Vital role of herbal medicines in womens health: A perspective review. African Journal of Plant Science. 2015;9. 320-326. https://doi.org/10.5897/AJPS2015.1315
28. Turkmenoglu FP, Kutsal YG, Dolgun AB, Diker Y, Baydar T. Evaluation of herbal product use and possible herb-drug interactions in Turkish elderly. Complement Ther Clin Pract. 2016 May;23:46-51. https://doi.org/10.1016/j.ctcp.2016.03.004. Epub 2016 Mar 18. PMID: 27157958
29. Neslihan P, Topaloğlu M, Özer C, Alp H. Herbal supplement usage in cardiac patients. Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology. 2017;45. 10.5543/tkda.2017.79160
30. Kaner G, Karaalp C, Seremet-Kürklü N. Üniversite öğrencileri ve ailelerinde bitkisel ürün kullanim sikliğinin ve bitkisel ürün kullanimini etkileyen faktörlerin belirlenmesi. Turk Hijyen ve Deneysel Biyoloji Dergisi. 2017:74:37-54. 10.5505/TurkHijyen.2016.21347
31. Görgülü Ö. The Prevalence of the Herbal Medicine Use in the South of Turkey. Journal of Traditional Medical Complementary Therapies. 2020;3:311-318. 10.5336/jtracom.2020-74555. https://doi.org/10.5336/jtracom.2020-74555