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Osteoporotik omurga kompresyon kırıklarında tek taraflı ve çift taraflı perkütan vertebroplasti uygulamalarının klinik ve radyolojik sonuçlarının karşılaştırılması

Yıl 2026, Cilt: 10 Sayı: 1 , 157 - 163 , 29.04.2026
https://doi.org/10.29058/mjwbs.1793536
https://izlik.org/JA49AZ53FR

Öz

Amaç: Vertebra kompresyon kırıkları (VKK) , yaşlı popülasyonda ağrı ve fonksiyon kaybının en yaygın nedenlerinden biridir. Perkütan vertebroplasti (PVP), minimal invaziv ve kanıtlanmış bir tedavi yöntemidir; ancak optimal yaklaşımın (tek taraflı ve ya çift taraflı ) olması gerektiği halen tartışmalıdır. Bu çalışmanın amacı, ağrılı osteoporotik VKK’lerde tek taraflı ve çift taraflı PVP uygulamalarının klinik ve radyolojik sonuçlarını karşılaştırmaktır.
Gereç ve Yöntemler: 2014–2024 yılları arasında 203 hasta (73 erkek, 130 kadın; ort. yaş 65,3 ± 8,9 yıl) ve toplam 309 vertebra düzeyi retrospektif olarak incelendi. Hastalara tek taraflı (n = 104) veya çift taraflı (n = 99) PVP uygulandı. Klinik değerlendirmede VAS ve Oswestry Disabilite İndeksi (ODI) kullanılırken, radyolojik sonuçlarda anterior vertebra yüksekliği restorasyonu ve segmental Cobb açısı düzelmesi değerlendirildi.
Bulgular: Her iki yaklaşım da anlamlı ağrı azalması ve fonksiyonel iyileşme sağladı. Çift taraflı PVP, tek taraflı PVP’ye kıyasla daha düşük postoperatif VAS (1,9 vs 2,1; p = 0,040) ve ODI skorları (%23,1 vs %26,3; p = 0,02) ile sonuçlandı. Radyolojik olarak çift taraflı girişimler, daha yüksek anterior yükseklik restorasyonu (%25,8 vs %19,2; p = 0,001) ve daha fazla Cobb açısı düzelmesi (9,1° vs 6,4°; p = 0,001) sağladı. Sement kaçağı oranları her iki grupta benzerdi ve semptomatik komplikasyon görülmedi.
Sonuç: Hem tek taraflı hem de çift taraflı PVP, osteoporotik VKK tedavisinde güvenli ve etkili yöntemlerdir. Çift taraflı PVP daha üstün radyolojik düzelme sağlarken, tek taraflı PVP daha az cerrahi yük nedeniyle avantajlıdır. Tedavi seçimi, hasta anatomisi ve prosedürel hedefler göz önünde bulundurularak bireyselleştirilmelidir.

Kaynakça

  • Ateş A, Gemalmaz HC, Deveci MA, Şimşek SA, Çetin E, Şenköylü A. Comparison of effectiveness of kyphoplasty and vertebroplasty in patients with osteoporotic vertebra fractures. Acta Orthop Traumatol Turc 2016;50(6):619-622. http://doi.org/10.1016/j.aott.2016.10.001
  • Qiao Y, Wang X, Liu Y, Hu J, Yuan FH, Zhao ZG. Comparison of unilateral and bilateral percutaneous kyphoplasty for osteoporotic vertebral compression fractures. J Pain Res 2023;16:1813-1823. http://doi.org/10.2147/JPR.S413048
  • Chen JF, Lee ST, Lui TN, Wu CT, Liao CC. Percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures: A preliminary report. Chang Gung Med J 2002;25(5):306-314
  • McKiernan F, Faciszewski T, Jensen R. Quality of life following vertebroplasty. J Bone Joint Surg Am 2004;86(12):2600-2606. http://doi.org/10.2106/00004623-200412000-00007
  • Zhang LG, Gu X, Zhang HL, Zhang QG, Cai XB, Tao K. Unilateral or Bilateral Percutaneous Vertebroplasty for Acute Osteoporotic Vertebral Fracture: A Prospective Study. J Spinal Disord Tech 2015;28(2):E85-E88. http://doi.org/10.1097/BSD.0000000000000064
  • Galibert P, Deramnd H, Rosat P, Le Gars D. Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 1987;33:166-168
  • Kobayashi K, Shimoyama K, Nakamura K, Murata K. Percutaneous vertebroplasty immediately relieves pain of osteoporotic vertebral compression fractures and prevents prolonged immobilization of patients. Eur Radiol 2005;15(2):360-367. http://doi.org/10.1007/s00330-004-2536-8
  • Purkayastha S, Gupta AK, Kapilamoorthy TR, Kesavadas C, Thomas B, Krishnamoorthy T, et al. Percutaneous vertebroplasty in the management of vertebral lesions. Neurol India 2005;53(2):167-173
  • Hee HT. Percutaneous vertebroplasty: Current concepts and local experience. Neurol India 2005;53(4):475-482
  • Zhao X, Han X, Li C, Han B, Zhu T, Shi Y. Comparative study between unilateral and bilateral extrapedicular approaches for osteoporotic vertebral compression fractures: A retrospective study. Sci Prog 2025;108(1). http://doi.org/10.1177/00368504241302468
  • Zhan Y, Jiang J, Liao H, Tan H, Yang K. Risk Factors for Cement Leakage After Vertebroplasty or Kyphoplasty: A Meta-Analysis of Published Evidence. World Neurosurg 2017;101:633-642. http://doi.org/10.1016/j.wneu.2017.02.038
  • Baroud G, Bohner M. Biomechanical impact of vertebroplasty: Postoperative biomechanics of vertebroplasty. Joint Bone Spine 2006;73(2):144-150. http://doi.org/10.1016/j.jbspin.2005.07.003
  • Jin P, Liu X, Li M, Sun G. Clinical Experience Using a Remote Control Injection System in Vertebroplasty: Feasibility, Safety, and Cement Leakage of Osteoporotic and Malignant Compression Fractures. Clin Spine Surg 2017;30(3):E305-E309. http://doi.org/10.1097/BSD.0000000000000284
  • Dai H, Liu Y, Han Q, Zhang A, Chen H, Qu Y, et al. Biomechanical comparison between unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A finite element analysis. Front Bioeng Biotechnol 2022;10. http://doi.org/10.3389/fbioe.2022.950737
  • Kim JM, Shin DA, Byun DH, Kim HS, Kim S, Kim HI. Effect of bone cement volume and stiffness on occurrences of adjacent vertebral fractures after vertebroplasty. J Korean Neurosurg Soc 2012;52(5):435-440. http://doi.org/10.3340/jkns.2012.52.5.435
  • Tan Y, Liu J, Li X, Fang L, He D, Tan J, et al. Multilevel unilateral versus bilateral pedicular percutaneous vertebroplasty for osteoporotic vertebral compression fractures. Front Surg 2023;9. http://doi.org/10.3389/fsurg.2022.1049980
  • Lee HJ, Kim T, Park J, Cho J, Yi JS. Quantitative Comparison of Vertebral Structural Changes After Percutaneous Vertebroplasty Between Unilateral Extrapedicular Approach and Bilateral Transpedicular Approach Using Voxel-Based Morphometry. Neurospine 2023;20(4):1287-1302. http://doi.org/10.14245/ns.2346536.268
  • Fu X, Li Y, Tian P, Xu G jun, Li Z jun. Comparison between unilateral curved and bilateral straight percutaneous vertebral augmentation in the treatment of osteoporotic vertebral compression fractures: A meta-analysis. Jt Dis Relat Surg 2023;34(2):237-244. http://doi.org/10.52312/jdrs.2023.1034
  • Sun H, Li C. Comparison of unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A systematic review and meta-analysis. J Orthop Surg Res 2016;11(1). http://doi.org/10.1186/s13018-016-0424-7
  • Meral M, Orunoğlu M, Biçer E, Berkyürek E, Koç RK. Osteoporotic vertebral fracture; comparative analysis of unilateral and bilateral vertebroplasty results. J Turk Spinal Surg 2024;35(1):38-42
  • Dai C, Wang S, Zheng L, Wang K, Yu H, Chen Y. Unilateral and Bilateral Percutaneous Vertebroplasty for Thoracolumbar Osteoporotic Vertebral Compression Fracture with Distant Lumbosacral Pain: A Single-Center Retrospective Analysis. World Neurosurg 2025;195. http://doi.org/10.1016/j.wneu.2024.121457
  • Chen Y, Zhang H, Chen H, Ou Z, Fu Y, Zhang J. Comparison of the effectiveness and safety of unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A protocol for systematic review and meta-analysis. Medicine (Baltimore) 2021;100:e28453. http://doi.org/10.1097/MD.0000000000028453
  • Takura T, Yoshimatsu M, Sugimori H, Takizawa K, Furumatsu Y, Ikeda H. Cost-Effectiveness Analysis of Percutaneous Vertebroplasty for Osteoporotic Compression Fractures. Clin Spine Surg 2017;30(3):E205-E210. http://doi.org/10.1097/BSD.0000000000000302
  • Kallmes DF, Jensen ME. Percutaneous vertebroplasty. Radiology 2003;229:27-36. http://doi.org/10.1148/radiol.2291020722
  • Zhong R, Liu J, Wang R, Liu Y, Chen B, Jiang W, et al. Unilateral curved versus bipedicular vertebroplasty in the treatment of osteoporotic vertebral compression fractures. BMC Surg 2019;19(1). http://doi.org/10.1186/s12893-019-0647-0
  • Shi D, Li X, Huang F, Wei G, Lin Z. Unilateral percutaneous vertebroplasty in osteoporotic vertebral compression fractures: A clinical efficacy evaluation. Exp Ther Med 2024;27(4). http://doi.org/10.3892/etm.2024.12345
  • Liu Z, Zhang H, Ma X, Zhang W, Shi B. Comparison of the efficacy of unilateral versus bilateral pedicle approach vertebroplasty in the treatment of osteoporotic thoracic and lumbar vertebral compression fractures: A retrospective cohort study. Medicine (Baltimore) 2025;104(31):e43632. http://doi.org/10.1097/MD.0000000000043632
  • Kim T, Park J, Cho J, Yi JS, Lee HJ. Quantitative Comparison of Vertebral Structural Changes After Percutaneous Vertebroplasty Between Unilateral Extrapedicular Approach and Bilateral Transpedicular Approach Using Voxel-Based Morphometry. Neurospine 2023;20(4):1287-1302. http://doi.org/10.14245/ns.2346536.268

Clinical and radiological outcome comparison of unilateral vs. bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures

Yıl 2026, Cilt: 10 Sayı: 1 , 157 - 163 , 29.04.2026
https://doi.org/10.29058/mjwbs.1793536
https://izlik.org/JA49AZ53FR

Öz

Aim: Vertebral compression fractures are a common cause of pain and disability in the elderly population. Percutaneous vertebroplasty is an established minimally invasive intervention, yet the optimal approach (unilateral or bilateral) remains controversial. This study focused on comparing the clinical and radiological outcomes of unilateral versus bilateral percutaneous vertebroplasty in patients with painful osteoporotic vertebral compression fractures.
Material and Methods: A retrospective review was conducted on 203 patients (73 males, 130 females; mean age 65.3 ± 8.9 years) with 309 treated vertebral levels from 2014 to 2024. Patients underwent either unilateral (n = 104) or bilateral (n = 99) PVP. Pain and disability were assessed using the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI), while radiological outcomes included anterior vertebral height restoration and segmental Cobb angle correction.
Results: Both approaches provided significant pain relief and functional improvement. Bilateral PVP achieved lower postoperative VAS (1.9 vs 2.1, p = 0.040) and ODI scores (23.1% vs 26.3%, p = 0.020) compared to unilateral PVP. Radiologically, bilateral procedures resulted in superior anterior height restoration (25.8% vs 19.2%, p = 0.001) and greater Cobb angle correction (9.1° vs 6.4°, p = 0.001). Cement leakage rates were similar in both groups (≈4%), with no symptomatic complications.
Conclusion: Unilateral and bilateral PVP are both safe and effective for osteoporotic VCFs. Bilateral PVP demonstrated superior radiological correction, whereas unilateral PVP remains advantageous due to reduced operative burden. Treatment decisions should be individualized based on patient anatomy and procedural goals.

Kaynakça

  • Ateş A, Gemalmaz HC, Deveci MA, Şimşek SA, Çetin E, Şenköylü A. Comparison of effectiveness of kyphoplasty and vertebroplasty in patients with osteoporotic vertebra fractures. Acta Orthop Traumatol Turc 2016;50(6):619-622. http://doi.org/10.1016/j.aott.2016.10.001
  • Qiao Y, Wang X, Liu Y, Hu J, Yuan FH, Zhao ZG. Comparison of unilateral and bilateral percutaneous kyphoplasty for osteoporotic vertebral compression fractures. J Pain Res 2023;16:1813-1823. http://doi.org/10.2147/JPR.S413048
  • Chen JF, Lee ST, Lui TN, Wu CT, Liao CC. Percutaneous vertebroplasty for the treatment of osteoporotic vertebral compression fractures: A preliminary report. Chang Gung Med J 2002;25(5):306-314
  • McKiernan F, Faciszewski T, Jensen R. Quality of life following vertebroplasty. J Bone Joint Surg Am 2004;86(12):2600-2606. http://doi.org/10.2106/00004623-200412000-00007
  • Zhang LG, Gu X, Zhang HL, Zhang QG, Cai XB, Tao K. Unilateral or Bilateral Percutaneous Vertebroplasty for Acute Osteoporotic Vertebral Fracture: A Prospective Study. J Spinal Disord Tech 2015;28(2):E85-E88. http://doi.org/10.1097/BSD.0000000000000064
  • Galibert P, Deramnd H, Rosat P, Le Gars D. Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 1987;33:166-168
  • Kobayashi K, Shimoyama K, Nakamura K, Murata K. Percutaneous vertebroplasty immediately relieves pain of osteoporotic vertebral compression fractures and prevents prolonged immobilization of patients. Eur Radiol 2005;15(2):360-367. http://doi.org/10.1007/s00330-004-2536-8
  • Purkayastha S, Gupta AK, Kapilamoorthy TR, Kesavadas C, Thomas B, Krishnamoorthy T, et al. Percutaneous vertebroplasty in the management of vertebral lesions. Neurol India 2005;53(2):167-173
  • Hee HT. Percutaneous vertebroplasty: Current concepts and local experience. Neurol India 2005;53(4):475-482
  • Zhao X, Han X, Li C, Han B, Zhu T, Shi Y. Comparative study between unilateral and bilateral extrapedicular approaches for osteoporotic vertebral compression fractures: A retrospective study. Sci Prog 2025;108(1). http://doi.org/10.1177/00368504241302468
  • Zhan Y, Jiang J, Liao H, Tan H, Yang K. Risk Factors for Cement Leakage After Vertebroplasty or Kyphoplasty: A Meta-Analysis of Published Evidence. World Neurosurg 2017;101:633-642. http://doi.org/10.1016/j.wneu.2017.02.038
  • Baroud G, Bohner M. Biomechanical impact of vertebroplasty: Postoperative biomechanics of vertebroplasty. Joint Bone Spine 2006;73(2):144-150. http://doi.org/10.1016/j.jbspin.2005.07.003
  • Jin P, Liu X, Li M, Sun G. Clinical Experience Using a Remote Control Injection System in Vertebroplasty: Feasibility, Safety, and Cement Leakage of Osteoporotic and Malignant Compression Fractures. Clin Spine Surg 2017;30(3):E305-E309. http://doi.org/10.1097/BSD.0000000000000284
  • Dai H, Liu Y, Han Q, Zhang A, Chen H, Qu Y, et al. Biomechanical comparison between unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A finite element analysis. Front Bioeng Biotechnol 2022;10. http://doi.org/10.3389/fbioe.2022.950737
  • Kim JM, Shin DA, Byun DH, Kim HS, Kim S, Kim HI. Effect of bone cement volume and stiffness on occurrences of adjacent vertebral fractures after vertebroplasty. J Korean Neurosurg Soc 2012;52(5):435-440. http://doi.org/10.3340/jkns.2012.52.5.435
  • Tan Y, Liu J, Li X, Fang L, He D, Tan J, et al. Multilevel unilateral versus bilateral pedicular percutaneous vertebroplasty for osteoporotic vertebral compression fractures. Front Surg 2023;9. http://doi.org/10.3389/fsurg.2022.1049980
  • Lee HJ, Kim T, Park J, Cho J, Yi JS. Quantitative Comparison of Vertebral Structural Changes After Percutaneous Vertebroplasty Between Unilateral Extrapedicular Approach and Bilateral Transpedicular Approach Using Voxel-Based Morphometry. Neurospine 2023;20(4):1287-1302. http://doi.org/10.14245/ns.2346536.268
  • Fu X, Li Y, Tian P, Xu G jun, Li Z jun. Comparison between unilateral curved and bilateral straight percutaneous vertebral augmentation in the treatment of osteoporotic vertebral compression fractures: A meta-analysis. Jt Dis Relat Surg 2023;34(2):237-244. http://doi.org/10.52312/jdrs.2023.1034
  • Sun H, Li C. Comparison of unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A systematic review and meta-analysis. J Orthop Surg Res 2016;11(1). http://doi.org/10.1186/s13018-016-0424-7
  • Meral M, Orunoğlu M, Biçer E, Berkyürek E, Koç RK. Osteoporotic vertebral fracture; comparative analysis of unilateral and bilateral vertebroplasty results. J Turk Spinal Surg 2024;35(1):38-42
  • Dai C, Wang S, Zheng L, Wang K, Yu H, Chen Y. Unilateral and Bilateral Percutaneous Vertebroplasty for Thoracolumbar Osteoporotic Vertebral Compression Fracture with Distant Lumbosacral Pain: A Single-Center Retrospective Analysis. World Neurosurg 2025;195. http://doi.org/10.1016/j.wneu.2024.121457
  • Chen Y, Zhang H, Chen H, Ou Z, Fu Y, Zhang J. Comparison of the effectiveness and safety of unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A protocol for systematic review and meta-analysis. Medicine (Baltimore) 2021;100:e28453. http://doi.org/10.1097/MD.0000000000028453
  • Takura T, Yoshimatsu M, Sugimori H, Takizawa K, Furumatsu Y, Ikeda H. Cost-Effectiveness Analysis of Percutaneous Vertebroplasty for Osteoporotic Compression Fractures. Clin Spine Surg 2017;30(3):E205-E210. http://doi.org/10.1097/BSD.0000000000000302
  • Kallmes DF, Jensen ME. Percutaneous vertebroplasty. Radiology 2003;229:27-36. http://doi.org/10.1148/radiol.2291020722
  • Zhong R, Liu J, Wang R, Liu Y, Chen B, Jiang W, et al. Unilateral curved versus bipedicular vertebroplasty in the treatment of osteoporotic vertebral compression fractures. BMC Surg 2019;19(1). http://doi.org/10.1186/s12893-019-0647-0
  • Shi D, Li X, Huang F, Wei G, Lin Z. Unilateral percutaneous vertebroplasty in osteoporotic vertebral compression fractures: A clinical efficacy evaluation. Exp Ther Med 2024;27(4). http://doi.org/10.3892/etm.2024.12345
  • Liu Z, Zhang H, Ma X, Zhang W, Shi B. Comparison of the efficacy of unilateral versus bilateral pedicle approach vertebroplasty in the treatment of osteoporotic thoracic and lumbar vertebral compression fractures: A retrospective cohort study. Medicine (Baltimore) 2025;104(31):e43632. http://doi.org/10.1097/MD.0000000000043632
  • Kim T, Park J, Cho J, Yi JS, Lee HJ. Quantitative Comparison of Vertebral Structural Changes After Percutaneous Vertebroplasty Between Unilateral Extrapedicular Approach and Bilateral Transpedicular Approach Using Voxel-Based Morphometry. Neurospine 2023;20(4):1287-1302. http://doi.org/10.14245/ns.2346536.268
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Beyin ve Sinir Cerrahisi (Nöroşirurji)
Bölüm Araştırma Makalesi
Yazarlar

Levent Aydın 0000-0001-7015-4070

Buse Sarıgül 0000-0003-3732-3850

Tufan Agah Kartum 0000-0003-1529-6476

Gonca Gül Öndüç 0009-0001-3300-2163

Saime Ayça Şahin 0000-0002-8131-4524

Ali Fatih Ramazanoğlu 0000-0001-6500-5070

Gönderilme Tarihi 30 Eylül 2025
Kabul Tarihi 12 Mart 2026
Yayımlanma Tarihi 29 Nisan 2026
DOI https://doi.org/10.29058/mjwbs.1793536
IZ https://izlik.org/JA49AZ53FR
Yayımlandığı Sayı Yıl 2026 Cilt: 10 Sayı: 1

Kaynak Göster

Vancouver 1.Levent Aydın, Buse Sarıgül, Tufan Agah Kartum, Gonca Gül Öndüç, Saime Ayça Şahin, Ali Fatih Ramazanoğlu. Clinical and radiological outcome comparison of unilateral vs. bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures. Med J West Black Sea. 01 Nisan 2026;10(1):157-63. doi:10.29058/mjwbs.1793536

Batı Karadeniz Tıp Dergisi, Zonguldak Bülent Ecevit Üniversitesi tarafından yayımlanan, uluslararası, hakemli ve açık erişimli bir dergidir. İlk sayısı 2017 yılında yayımlanan dergi, yılda üç kez (Nisan, Ağustos ve Aralık aylarında) yayımlanmakta olup Türkçe ve İngilizce makalelere yer verir.