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Pediatrik adenotonsillektomi sonrası uyanma deliryumu üzerine preemptif analjezi ve preoperatif anksiyetenin etkileri

Yıl 2026, Cilt: 10 Sayı: 1 , 142 - 150 , 29.04.2026
https://doi.org/10.29058/mjwbs.1835988
https://izlik.org/JA63CZ25LK

Öz

Amaç: Postoperatif uyanma deliryumu (PED), özellikle çocuklarda anesteziden uyanma sırasında huzursuzluk, yönelim bozukluğu ve ajitasyon ile karakterizedir. Etiyolojisinde preoperatif anksiyete, baş-boyun cerrahisi, inhalasyon ajanları ve ağrı rol oynar. Bu çalışmada, pediatrik adenotonsillektomi sonrası PED üzerine preemptif analjezi ve preoperatif anksiyetenin etkileri araştırılmıştır.
Gereç ve Yöntemler: Etik kurul onayı ve yazılı ebeveyn onamı alındıktan sonra 64 pediatrik hasta çalışmaya dahil edildi. Bu prospektif gözlemsel çalışmada hastalar, intravenöz asetaminofen uygulama zamanına göre; cerrahi insizyondan 30 dakika önce (Grup 1) veya cerrahinin bitiminden 15 dakika önce (Grup 2) olacak şekilde sınıflandırıldı. Preoperatif anksiyete modified Yale Preoperative Anxiety Scale (m-YPAS) ile, postoperatif deliryum Pediatric Anesthesia Emergence Delirium (PAED) ölçeği ile ve ağrı Wong-Baker Faces Pain Scale (WBFPS) ile değerlendirildi. Ölçümler postoperatif 0, 5, 10, 15, 30, 45 ve 60. dakikalarda kaydedildi. p<0,05 değeri anlamlı kabul edildi.
Bulgular: Gruplar demografik özellik, anestezi süresi, cerrahi geçmiş, ebeveyn memnuniyeti ve komplikasyonlar açısından benzer bulunmuştur. Her iki grupta preoperatif anksiyete yüksekti (m-YPAS ≥30). Grup 1’in ekstübasyon süresi anlamlı olarak daha kısaydı (p<0.001). PAED skorları Grup 1’de 10 dakika, Grup 2’de 15 dakika ≥10 olarak kaldı. PAED ve WBFPS skorları zamanla azalmış ve her iki grupta pozitif korelasyon göstermiştir (p<0.05).
Sonuç: Preemptif analjezi postoperatif ağrıyı azaltmış ancak ilk 10 dakikadaki PED skorlarını anlamlı şekilde etkilememiştir. Bulgular, PED’nin önlenmesinde hem anksiyete hem de ağrı yönetiminin birlikte ele alınmasının önemini göstermektedir.

Kaynakça

  • Aldamluji N, Burgess A, Pogatzki-Zahn E, Raeder J, Beloeil H; PROSPECT Working Group collaborators*. PROSPECT guideline for tonsillectomy: systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia. 2021;76(7):947-961. https://doi.org/10.1111/anae.15491
  • Albornoz AE, Rana M, Hayes J, Englesakis M, Tsang M, Amin R, et al. Perioperative clinical practice recommendations for pediatric tonsillectomy: a systematic review. Can J Anaesth. 2024;71(2):187-200. https://doi.org/10.1007/s12630-023-02563-1
  • Redondo-Enríquez JM, Rivas-Medina M, Galán-Mateos MM. Updating Clinical Practice: Improving Perioperative Pain Management for Adeno-Tonsillectomy in Children. Children (Basel). 2024;11(10):1190. https://doi.org/10.3390/children11101190
  • Yang X, Lin C, Chen S, Huang Y, Cheng Q, Yao Y. Remimazolam for the prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study. Drug Des Devel Ther. 2022;16:3413-3420. https://doi.org/10.2147/DDDT.S379870
  • Zieliński J, Morawska-Kochman M, Dudek K, Czapla M, Zatoński T. The effect of pre-emptive analgesia on the postoperative pain in pediatric otolaryngology: a randomized, controlled trial. J Clin Med. 2022;11(10):2713. https://doi.org/10.3390/jcm11102713
  • Liu K, Liu C, Ulualp SO. Prevalence of emergence delirium in children undergoing tonsillectomy and adenoidectomy. Anesthesiol Res Pract. 2022;2022:1465999. https://doi.org/10.1155/2022/1465999
  • Ingelmo PM, Somaini M, Engelhardt T. Emergence delirium may not just be a recovery room problem. Paediatr Anaesth. 2021;31(10):1022-1024. https://doi.org/10.1111/pan.14238
  • Cettler M, Zielińska M, Rosada-Kurasińska J, Kubica-Cielińska A, Jarosz K, Bartkowska-Śniatkowska A. Guidelines for treatment of acute pain in children - the consensus statement of the Section of Paediatric Anaesthesiology and Intensive Therapy of the Polish Society of Anaesthesiology and Intensive Therapy. Anaesthesiol Intensive Ther. 2022;54(3):197-218. https://doi.org/10.5114/ait.2022.118693
  • Urits I, Peck J, Giacomazzi S, Patel R, Wolf J, Mathew D, et al. Emergence delirium in perioperative pediatric care: a review of current evidence and new directions. Adv Ther. 2020;37(5):1897-1909. https://doi.org/10.1007/s12325-020-01268-3
  • Zieliński J, Morawska-Kochman M, Zatoński T. Pain assessment and management in children in the postoperative period: A review of the most commonly used postoperative pain assessment tools, new diagnostic methods and the latest guidelines for postoperative pain therapy in children. Adv Clin Exp Med. 2020;29(3):365-374. https://doi.org/10.17219/acem/112600
  • Xuan C, Yan W, Wang D, Li C, Ma H, Mueller A, et al. Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis. Br J Anaesth. 2022;129(6):946-958. https://doi.org/10.1016/j.bja.2022.08.015
  • Song IK, Park YH, Lee JH, Kim JT, Choi IH, Kim HS. Randomized controlled trial on preemptive analgesia for acute postoperative pain management in children. Paediatr Anaesth. 2016;26(4):438-443. https://doi.org/10.1111/pan.12854
  • Kain ZN, Mayes LC, Cicchetti DV, Bagnall AL, Finley JD, Hofstadter MB. The Yale Preoperative Anxiety Scale: how does it compare with a “gold standard”? Anesth Analg. 1997;85(4):783-788. https://doi.org/10.1097/00000539-199710000-00012
  • Hatipoğlu Z, Kırdök O, Özcengiz D. Validity and reliability of the Turkish version of the modified yale preoperative anxiety scale. Turk J Med Sci. 2019;49(3):730-737. doi: 10.3906/sag-1612-113.
  • Wong DL, Baker CM. Pain in children: Comparison of assessment scales. Pediatr Nurs. 1988;14(1):9-17.
  • Sikich N, Lerman J. Development and psychometric evalu ation of the pediatric anesthesia emergence delirium scale. Anesthesiology. 2004;100:1138-1145. https://doi.org/10.1097/00000542-200405000-00015
  • Karasu D, Karaca U, Özgünay SE, Yılmaz C, Yetik F, Özkaya G. The frequency of emergence delirium in children undergoing outpatient anaesthesia for magnetic resonance imaging. Int J Clin Pract. 2021;75(11):e14763. https://doi.org/10.1111/ijcp.14763
  • Yucedag F, Sezgin A, Bilge A, Basaran B. The effect on perioperative anxiety and emergence delirium of the child or parent’s preference for parental accompaniment during anesthesia induction in children undergoing adenotonsillectomy surgery. Paediatr Anaesth. 2024;34(8):792-799. https://doi.org/10.1111/pan.14677
  • Polat R, Peker K, Baran I, Bumin Aydın G, Topçu Gülöksüz Ç, Dönmez A. Comparison between dexmedetomidine and remifentanil infusion in emergence agitation during recovery after nasal surgery: A randomized double-blind trial [retracted in: Anaesthesiologie. 2024;73(1):64. https://doi.org/10.1007/s00101-022-01177-4
  • Kain ZN, Mayes LC, Caldwell-Andrews AA, Karas DE, McClain BC. Preoperative anxiety, postoperative pain, and behavioral recovery in young children undergoing surgery. Pediatrics. 2006;118(2):651-658. https://doi.org/10.1542/peds.2005-2920
  • Chieng YJ, Chan WC, Liam JL, Klainin-Yobas P, Wang W, He HG. Exploring influencing factors of postoperative pain in school-age children undergoing elective surgery. J Spec Pediatr Nurs. 2013;18(3):243-252. https://doi.org/10.1111/jspn.12033
  • Jeizan P, Baharimehr K, Kamvar R, Abolghasemi Fard A, Zojaji S, Karimi A, et al. Dexmedetomidine Leads to Less Emergence Delirium Compared to Midazolam in Pediatric Tonsillectomy and/or Adenoidectomy: A Systematic Review and Meta-Analysis. Cureus. 2025;17(4):e81686. https://doi.org/10.7759/cureus.81686
  • Yao J, Gong H, Zhao X, Peng Q, Zhao H, Yu S. Parental presence and intranasal dexmedetomidine for the prevention of anxiety during anesthesia induction in children undergoing tonsillectomy and/or adenoidectomy surgery: A randomized controlled trial. Front Pharmacol. 2022;13:1015357. https://doi.org/10.3389/fphar.2022.1015357
  • Pierce CA, Voss B. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. Ann Pharmacother. 2010;44(3):489-506. https://doi.org/10.1345/aph.1M332
  • Prayunanto E, Widyastuti Y, Sari D. The association of modified Yale perioperative anxiety scale and pediatric anesthesia behavior on postoperative emergence delirium in children: A prospective cohort study. Bali J Anaesthesiol. 2023;7:88-93. https://doi.org/10.4103/bjoa.bjoa_24_23
  • Kain ZN, Caldwell-Andrews AA, Maranets I, McClain B, Gaal D, Mayes LC, et al. Preoperative anxiety and emergence delirium and postoperative maladaptive behaviors. Anesth Analg. 2004;99(6):1648-1654. https://doi.org/10.1213/01.ANE.0000136471.36680.97
  • Farag RS, Spicer AC, Iyer G, Stevens JP, King A, Bain PA, et al. Incidence of emergence agitation in children undergoing sevoflurane anesthesia compared to isoflurane anesthesia: An updated systematic review and meta-analysis. Paediatr Anaesth. 2024;34(4):304-317. https://doi.org/10.1111/pan.14596

Effects of preemptive analgesia and preoperative anxiety on emergence delirium after pediatric adenotonsillectomy

Yıl 2026, Cilt: 10 Sayı: 1 , 142 - 150 , 29.04.2026
https://doi.org/10.29058/mjwbs.1835988
https://izlik.org/JA63CZ25LK

Öz

Aim: Postoperative emergence delirium (PED) is characterized by restlessness, disorientation, and agitation, particularly in children during emergence from anesthesia. Its etiology includes preoperative anxiety, head-neck surgery, inhalation agents, and pain. This study evaluated the effects of preemptive analgesia and preoperative anxiety on PED after pediatric adenotonsillectomy.
Material and Methods: After ethics committee approval and written parental consent were obtained, 64 pediatric patients were enrolled. In this prospective observational study, patients were categorized according to the timing of intravenous acetaminophen administration: 30 minutes before surgical incision(Group 1) or 15 minutes before the end of surgery (Group 2). Preoperative anxiety was assessed using the modified Yale Preoperative Anxiety Scale (m-YPAS), postoperative delirium using the Pediatric Anesthesia Emergence Delirium (PAED) scale, and pain using the Wong-Baker Faces Pain Scale (WBFPS). Measurements were recorded at 0, 5, 10, 15, 30, 45, and 60 minutes postoperatively. A p value <0.05 was considered statistically significant.
Results: Groups were comparable in demographics, anesthesia time, surgical history, parental satisfaction, and complications. Preoperative anxiety was high in both groups (m-YPAS ≥30). Group 1 had shorter extubation times(p<0.001). PAED scores ≥10 persisted for 10 min in Group 1 and 15 min in Group 2. PAED and WBFPS scores decreased over time, with a positive correlation between them in both groups (p<0.05).
Conclusion: Preemptive analgesia reduced postoperative pain but did not significantly affect PED within the first 10 minutes. These findings suggest that managing both anxiety and pain may be necessary to prevent PED in pediatric patients. Further studies are warranted.

Kaynakça

  • Aldamluji N, Burgess A, Pogatzki-Zahn E, Raeder J, Beloeil H; PROSPECT Working Group collaborators*. PROSPECT guideline for tonsillectomy: systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia. 2021;76(7):947-961. https://doi.org/10.1111/anae.15491
  • Albornoz AE, Rana M, Hayes J, Englesakis M, Tsang M, Amin R, et al. Perioperative clinical practice recommendations for pediatric tonsillectomy: a systematic review. Can J Anaesth. 2024;71(2):187-200. https://doi.org/10.1007/s12630-023-02563-1
  • Redondo-Enríquez JM, Rivas-Medina M, Galán-Mateos MM. Updating Clinical Practice: Improving Perioperative Pain Management for Adeno-Tonsillectomy in Children. Children (Basel). 2024;11(10):1190. https://doi.org/10.3390/children11101190
  • Yang X, Lin C, Chen S, Huang Y, Cheng Q, Yao Y. Remimazolam for the prevention of emergence delirium in children following tonsillectomy and adenoidectomy under sevoflurane anesthesia: a randomized controlled study. Drug Des Devel Ther. 2022;16:3413-3420. https://doi.org/10.2147/DDDT.S379870
  • Zieliński J, Morawska-Kochman M, Dudek K, Czapla M, Zatoński T. The effect of pre-emptive analgesia on the postoperative pain in pediatric otolaryngology: a randomized, controlled trial. J Clin Med. 2022;11(10):2713. https://doi.org/10.3390/jcm11102713
  • Liu K, Liu C, Ulualp SO. Prevalence of emergence delirium in children undergoing tonsillectomy and adenoidectomy. Anesthesiol Res Pract. 2022;2022:1465999. https://doi.org/10.1155/2022/1465999
  • Ingelmo PM, Somaini M, Engelhardt T. Emergence delirium may not just be a recovery room problem. Paediatr Anaesth. 2021;31(10):1022-1024. https://doi.org/10.1111/pan.14238
  • Cettler M, Zielińska M, Rosada-Kurasińska J, Kubica-Cielińska A, Jarosz K, Bartkowska-Śniatkowska A. Guidelines for treatment of acute pain in children - the consensus statement of the Section of Paediatric Anaesthesiology and Intensive Therapy of the Polish Society of Anaesthesiology and Intensive Therapy. Anaesthesiol Intensive Ther. 2022;54(3):197-218. https://doi.org/10.5114/ait.2022.118693
  • Urits I, Peck J, Giacomazzi S, Patel R, Wolf J, Mathew D, et al. Emergence delirium in perioperative pediatric care: a review of current evidence and new directions. Adv Ther. 2020;37(5):1897-1909. https://doi.org/10.1007/s12325-020-01268-3
  • Zieliński J, Morawska-Kochman M, Zatoński T. Pain assessment and management in children in the postoperative period: A review of the most commonly used postoperative pain assessment tools, new diagnostic methods and the latest guidelines for postoperative pain therapy in children. Adv Clin Exp Med. 2020;29(3):365-374. https://doi.org/10.17219/acem/112600
  • Xuan C, Yan W, Wang D, Li C, Ma H, Mueller A, et al. Efficacy of preemptive analgesia treatments for the management of postoperative pain: a network meta-analysis. Br J Anaesth. 2022;129(6):946-958. https://doi.org/10.1016/j.bja.2022.08.015
  • Song IK, Park YH, Lee JH, Kim JT, Choi IH, Kim HS. Randomized controlled trial on preemptive analgesia for acute postoperative pain management in children. Paediatr Anaesth. 2016;26(4):438-443. https://doi.org/10.1111/pan.12854
  • Kain ZN, Mayes LC, Cicchetti DV, Bagnall AL, Finley JD, Hofstadter MB. The Yale Preoperative Anxiety Scale: how does it compare with a “gold standard”? Anesth Analg. 1997;85(4):783-788. https://doi.org/10.1097/00000539-199710000-00012
  • Hatipoğlu Z, Kırdök O, Özcengiz D. Validity and reliability of the Turkish version of the modified yale preoperative anxiety scale. Turk J Med Sci. 2019;49(3):730-737. doi: 10.3906/sag-1612-113.
  • Wong DL, Baker CM. Pain in children: Comparison of assessment scales. Pediatr Nurs. 1988;14(1):9-17.
  • Sikich N, Lerman J. Development and psychometric evalu ation of the pediatric anesthesia emergence delirium scale. Anesthesiology. 2004;100:1138-1145. https://doi.org/10.1097/00000542-200405000-00015
  • Karasu D, Karaca U, Özgünay SE, Yılmaz C, Yetik F, Özkaya G. The frequency of emergence delirium in children undergoing outpatient anaesthesia for magnetic resonance imaging. Int J Clin Pract. 2021;75(11):e14763. https://doi.org/10.1111/ijcp.14763
  • Yucedag F, Sezgin A, Bilge A, Basaran B. The effect on perioperative anxiety and emergence delirium of the child or parent’s preference for parental accompaniment during anesthesia induction in children undergoing adenotonsillectomy surgery. Paediatr Anaesth. 2024;34(8):792-799. https://doi.org/10.1111/pan.14677
  • Polat R, Peker K, Baran I, Bumin Aydın G, Topçu Gülöksüz Ç, Dönmez A. Comparison between dexmedetomidine and remifentanil infusion in emergence agitation during recovery after nasal surgery: A randomized double-blind trial [retracted in: Anaesthesiologie. 2024;73(1):64. https://doi.org/10.1007/s00101-022-01177-4
  • Kain ZN, Mayes LC, Caldwell-Andrews AA, Karas DE, McClain BC. Preoperative anxiety, postoperative pain, and behavioral recovery in young children undergoing surgery. Pediatrics. 2006;118(2):651-658. https://doi.org/10.1542/peds.2005-2920
  • Chieng YJ, Chan WC, Liam JL, Klainin-Yobas P, Wang W, He HG. Exploring influencing factors of postoperative pain in school-age children undergoing elective surgery. J Spec Pediatr Nurs. 2013;18(3):243-252. https://doi.org/10.1111/jspn.12033
  • Jeizan P, Baharimehr K, Kamvar R, Abolghasemi Fard A, Zojaji S, Karimi A, et al. Dexmedetomidine Leads to Less Emergence Delirium Compared to Midazolam in Pediatric Tonsillectomy and/or Adenoidectomy: A Systematic Review and Meta-Analysis. Cureus. 2025;17(4):e81686. https://doi.org/10.7759/cureus.81686
  • Yao J, Gong H, Zhao X, Peng Q, Zhao H, Yu S. Parental presence and intranasal dexmedetomidine for the prevention of anxiety during anesthesia induction in children undergoing tonsillectomy and/or adenoidectomy surgery: A randomized controlled trial. Front Pharmacol. 2022;13:1015357. https://doi.org/10.3389/fphar.2022.1015357
  • Pierce CA, Voss B. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. Ann Pharmacother. 2010;44(3):489-506. https://doi.org/10.1345/aph.1M332
  • Prayunanto E, Widyastuti Y, Sari D. The association of modified Yale perioperative anxiety scale and pediatric anesthesia behavior on postoperative emergence delirium in children: A prospective cohort study. Bali J Anaesthesiol. 2023;7:88-93. https://doi.org/10.4103/bjoa.bjoa_24_23
  • Kain ZN, Caldwell-Andrews AA, Maranets I, McClain B, Gaal D, Mayes LC, et al. Preoperative anxiety and emergence delirium and postoperative maladaptive behaviors. Anesth Analg. 2004;99(6):1648-1654. https://doi.org/10.1213/01.ANE.0000136471.36680.97
  • Farag RS, Spicer AC, Iyer G, Stevens JP, King A, Bain PA, et al. Incidence of emergence agitation in children undergoing sevoflurane anesthesia compared to isoflurane anesthesia: An updated systematic review and meta-analysis. Paediatr Anaesth. 2024;34(4):304-317. https://doi.org/10.1111/pan.14596
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Anesteziyoloji
Bölüm Araştırma Makalesi
Yazarlar

Gamze Küçükosman 0000-0002-3586-7494

Bengü G. Köksal 0000-0002-1324-6144

Keziban Bollucuoğlu 0000-0002-7111-8685

Rahşan D. Okyay 0000-0002-0520-7532

Dilay İ. Alp 0000-0003-3744-1996

Özcan Pişkin 0000-0003-3538-0317

Hilal Ayoğlu 0000-0002-6869-5932

Gönderilme Tarihi 5 Aralık 2025
Kabul Tarihi 6 Mart 2026
Yayımlanma Tarihi 29 Nisan 2026
DOI https://doi.org/10.29058/mjwbs.1835988
IZ https://izlik.org/JA63CZ25LK
Yayımlandığı Sayı Yıl 2026 Cilt: 10 Sayı: 1

Kaynak Göster

Vancouver 1.Gamze Küçükosman, Bengü G. Köksal, Keziban Bollucuoğlu, Rahşan D. Okyay, Dilay İ. Alp, Özcan Pişkin, Hilal Ayoğlu. Effects of preemptive analgesia and preoperative anxiety on emergence delirium after pediatric adenotonsillectomy. Med J West Black Sea. 01 Nisan 2026;10(1):142-50. doi:10.29058/mjwbs.1835988

Batı Karadeniz Tıp Dergisi, Zonguldak Bülent Ecevit Üniversitesi tarafından yayımlanan, uluslararası, hakemli ve açık erişimli bir dergidir. İlk sayısı 2017 yılında yayımlanan dergi, yılda üç kez (Nisan, Ağustos ve Aralık aylarında) yayımlanmakta olup Türkçe ve İngilizce makalelere yer verir.