Facial and Peripheral Edema Associated with Zuclopenthixol Decanoate Longacting Injectable: A Case Report

Yıl 2019, Cilt: 3 Sayı: 1, 26 - 29, 30.04.2019

Mehmet Hamdi Orum , Mahmut Zabit Kara

Öz

Beta blockers, calcium channel blockers, non-steroidal antiinflammatory drugs, several hormonal drugs, and antipsychotics can
cause facial and peripheral edema but edema can rarely occur with
long-acting injectable forms of antipsychotics. There are case reports
associated with risperidone and paliperidone long-acting injectableinduced edema. According to our best knowledge, there are no
reports of zuclopenthixol decanoate long-acting injectable-related
facial edema. Herein, we present a female patient who developed
facial and bilateral peripheral edema after treatment with
zuclopenthixol decanoate long-acting injectable. 

Anahtar Kelimeler

Antipsychotics , depot preparation , edema , prolonged-action preparation , zuclopenthixol

Zuklopentiksol Dekanoat Uzun Etkili Depo Enjeksiyon Kullanımına Bağlı Yüz ve Periferik Ödem: Bir Olgu Sunumu

Öz

Beta blokerler, kalsiyum kanal blokerleri, non-steroid anti
inflamatuvar ilaçlar, bazı hormonal ilaçlar ve antipsikotikler yüz ve
periferik ödeme neden olabilir ancak antipsikotiklerin uzun etkili
depo enjeksiyon formlarına bağlı ödem nadir görülmektedir.
Risperidon ve paliperidonun uzun etkili enjekte edilebilir
formlarından kaynaklı ödem ile ilişkili olgu sunumları
bulunmaktadır. Bildiğimiz kadarıyla, zuklopentiksol dekanoat uzun
etkili depo enjeksiyon ile ilişkili yüz ödemi bildirilmemiştir. Bu olgu
sunumunda, zuklopentiksol dekanoat uzun etkili enjeksiyon ile
tedavi sonrası yüz ve bilateral periferik ödem gelişen bir kadın hasta
sunuldu. 

Anahtar Kelimeler

Antipsikotik , depo preparat , ödem , uzun etkili preparat , zuklopentiksol

Kaynakça

• 1. Stahl SM. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge (MA): Cambridge University Press; 2008.
• 2. Han-Almis, Celik M. Facial edema after olanzapine addition to sertraline: a case report. Anatolian Journal of Psychiatry 2017; 18(1): 46-47.
• 3. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed.; Author: Washington, DC, 2013.
• 4. Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of Naranjo Adverse Drug Reactions Probability Scale. Psychiatry and Clinical Psychopharmacology 2017; 27(2): 205-206.
• 5. Zink M, Kuwilsky A, Knopf U. Olanzapineassociated bilateral eyelid oedema. J Clin Psychopharmacol 2007; 27(2): 214-215.
• 6. Pelizza L. Long-acting risperidone-induced periorbital edema. J Clin Psychopharmacol 2008; 28(6): 709-710.
• 7. Cicek E, Cicek IE, Uguz F. Bilateral pretibial edema associated with paliperidone palmitate longacting injectable: A case report. Clin Psychopharmacol Neurosci 2017; 15(2): 184-186.
• 8. Umar MU, Abdullahi AT. Self-limiting atypical antipsychoticsinduced edema: clinical cases and systematic review. Indian J Psychol Med 2016; 38(3): 182-188.
• 9. Tamam L, Ozpoyraz N, Unal M. Oedema associated with risperidone: a case report and literature review. Clinical Drug Investigation 2002; 22(6): 411-414.
• 10. Knox ED, Stimmel GL. Clinical review of a long-acting, injectable formulation of risperidone. Clin Ther 2004; 26(12): 1994-2002.
• 11. Cooney C, Nagy A. Angio-oedema associated with risperidone. BMJ 1995; 311(7014): 1204.
• 12. Orum MH, Han-Almis B, Karaca HT. Rapid onset of pedal edema associated with risperidone in two male patients: Simultaneous clinical cases. Journal of Mood Disorders 2017; 7(4): 23