The Role of cancer antigen 125 (Ca 125), Human Epididymis Protein 4 (HE4), Soluble Mezotelin Related Protein (SMRP), Folate Receptor Alpha (FOLRα) in Estimation of Malignancy Risk in Pelvic Masses

Öz

An adnexal mass is a common gynecologic problem and malignancy must be excluded for any mass that is not clearly benign. Since ovarian cancer is the most common cause of gynecologic cancer death. The differential diagnosis of benign and malignant neoplastic masses is important for referring the patient to the gynecologic oncologist. Use of serum biomarkers for the diagnosis of ovarian cancer is an active area of investigation. Our research was performed between September 2014 and January 2017. Between 18 and 90 ages, 95 operated patients because of pelvic masses are included. Preoperatively CA 125, HE4, SMRP, FOLRα levels are measured for each patient and relationship between tumor marker levels and pathological reports is examined. HE4 and SMRP levels are found higher in malignant masses significantly. But CA 125 and FOLRα levels are not related with malignancy. HE4 and SMRP can be used as a serum biomarker for prediction of ovarian cancer according to our study. However the data should be supported with more studies.

Anahtar Kelimeler

• Pelvic Mass
• Ca 125 Antigen
• HE4 protein
• SMRP protein
• Folate Receptor alpha

Pelvik Kitlelerin Malignite Riski Değerlendirilmesinde Kanser Antijeni 125 (Ca 125), Human Epididymis Protein 4 (HE4), Soluble mesothelin-related protein (SMRP) ve Folat Reseptör Alfa (FOLRα) Ölçümünün Yeri

Öz

Adneksiyal kitle yaygın jinekolojik sorundur ve kitleler için malignite net bir şekilde dışlanmalıdır. Over kanserleri en mortal jinekolojik kanserlerdir. Benign ve malign adneksiyal kitlelerin ayırıcı tanısı, hastanın jinekolojik onkologa yönlendirilmesinde önemlidir. Over kanseri tanısında serum biyomarkerlarının kullanılması yaygın olarak araştırılmaktadır. Çalışmamız Ekim 2014 – Ocak 2017 tarihleri arasında yapıldı. Pelvik kitlesi olan 18 ve 90 yaşları arasında 95 hasta seçildi. Her hasta için preooperatif CA 125, HE4, SMRP, FOLRα seviyeleri ölçüldü ve patoloji sonuçları ile kan sonuçları arasındaki ilişki incelendi. HE4 ve SMRP malign kitlelerde önemli ölçüde yüksek bulundu. Fakat Ca 125 ve FOLRα seviyeleri malingnitede anlamsız saptandı. Çalışmamıza göre; HE4 ve SMRP over kanserini ön görmede kullanılabilir. Fakat daha fazla çalışmalar ile desteklenmelidir.

Anahtar Kelimeler

• Pelvik Kitle
• Kanser Antijeni 125
• HE4
• SMRP
• Folat Reseptör Alfa

Kaynakça

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