Atipik İzoenzim Paternli Benign Geçici Hiperfosfatazemi Olgu Sunumu

Öz

Alkalen fosfataz özellikle ergenlik döneminde artmış büyüme hızı nedeniyle ve gebelik döneminde ise fetal ve plesental yapıların üretimindeki artıştan dolayı 2- 3 kat artabilir.  Fakat hayatın hiçbir döneminde benign geçici hiperfosfatazemideki kadar artmaz. Benign geçici hiperfosfatazemi (BGH), sıklıkla 5 yaşından küçük çocuklarda serum alkalen fosfataz düzeyinin (ALP) normal değerlerin 3–50 kata kadar yüksekliği ile seyreden ve ALP’nin haftalar veya aylar içinde normale döndüğü benign bir klinik durumdur. Bu hastalıkta genellikle karaciğer ve kemik kaynaklı ALP izoenzimleri yükselir, ince barsak izoenzimlerin yükseldiği daha az görülmüştür. ALP yüksekliği ile başvuran hastalarda karaciğer, kemik hastalıkları ve maligniteler ekarte edildikten sonra benign geçici hiperfosfatazemi tanıda akla gelmelidir. Bu yazıda bulantı kusma nedeniyle takip edilen ve bakılan tetkiklerinde rastlantısal olarak ALP düzeyinin normalin 20 katı kadar yüksek olan ve diğer hastalıklar ekarte edilerek BGH tanısı konulan15 aylık kız hastayı literatürdeki bilgiler eşliğinde paylaşmak istedik. 

Anahtar Kelimeler

• Çocukluk çağında Alkalen Fosfataz Yüksekliği,Benign geçici hiperfosfatazemi

Benign Transient Hyperphosphatasemia with Atypical İsoenzyme Pattern: A Case Report

Öz

Alkaline phosphatase (ALP) can increase by 2-3 times due to the increase in the production of fetal and plasental structures during pregrancy, especially due to the increased growth rate during adolescence. But in any period of life it never increases as much as Benign Transient Hyperphosphatasemia (BTH). BTH is a benign clinical condition in which serum alkaline phosphatase  elevates 3-50 times higher than the normal rates in children under 5 years old. In this disease liver and bone derived ALP izoenzymes usually rise, small intestines’ rise less. For patients with elevated ALP, after excluding liver and bone diseases and malignancies, for diagnosis and differantial diagnosis benign transient hyperphosphatasemia should be taken into consideration.In this article, we would like to present that; 15 month-old girl patient who is followed up nuasea and vomiting, incedentally during the follow up ALP value was found 20 times higher than the normal value of a patient in the same age group  with in information of literatüre.

Kaynakça

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