Endokrinoloji Poliklinik Hastalarında Cinsiyet, Menopoz Durumu ve Glukoz Toleransının Osteokalsin Seviyeleri Üzerindeki Etkileri: Bir Vaka-Kontrol Çalışması

Öz

Amaç: Bu çalışmada, endokrinoloji poliklinik hastalarında cinsiyet, menopoz durumu ve glukoz toleransına göre total ve karboksile olmayan osteokalsin düzeylerinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Oral glukoz tolerans testi (OGTT) bulguları olan toplam 178 endokrinoloji poliklinik hastası dahil edildi. Antropometri verileri [vücut kütle indeksi (VKİ), bel çevresi (cm), vücut yağ yüzdesi (BFP) ve yağ kütlesi], glisemik parametreler [açlık kan şekeri (FBG), insülin), C-peptid, HbA1c ve insülin direnç direnci (HOMA-IR)], kan lipidleri ve serum osteokalsin (OCN) seviyeleri [toplam osteokalsin (tOCN) ve karboksile olmayan osteokalsin (uOCN)] cinsiyet, menopoz durumu ve glukoz tolerans durumu ile karşılaştırıldı.Bulgular: Cinsiyet ve menopoz durumu ile ilgili olarak tOCN ve uOCN düzeylerinde anlamlı bir farklılık kaydedilmedi. Glukoz toleransı normal olan hastalarda (p <0.05) ve premenopozal kadınlarda (p <0.05) tOCN ile VKİ, bel çevresi, BFP ve yağ kütlesi arasında negatif korelasyon vardı. Ayrıca tOCN, prediyabetli hastalarda BFP ve yağ kütlesi ile negatif (p <0.05), prediyabet grubunda açlık insülin düzeyleri ve HOMA-IR ile pozitif korelasyon gösterdi (p <0.05). Sonuç: Bulgularımız cinsiyet, menopoz durumu veya glukoz toleransı açısından tOCN ve uOCN düzeylerinde anlamlı bir farklılık göstermedi. İnsanlarda OCN-glukoz homeostaz bağlantısının daha sınırlı bir rolü ve karmaşık düzenlenmesi olasılığı dikkate alınmalıdır. OCN-glukoz homeostaz mekanizmasının kanıtlanabilmesi için daha geniş çaplı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Osteokalsin
• Diyabetes mellitus
• Tip 2
• Şişmanlık
• Glukoz tolerans testi
• Menopoz

The Effects of Sex, Menopausal Status, and Glucose Tolerance on Osteocalcin Levels in Endocrinology Outpatients: A Case-Control Study

Öz

menopausal status, and glucose tolerance in endocrinology outpatients. Material and Methods: A total of 178 endocrinology outpatients with oral glucose tolerance test (OGTT) findings were included. Data on anthropometrics [body mass index (BMI), waist circumference (cm), body fat percentage (BFP), and fat mass], glycemic parameters [fasting blood glucose (FBG), insulin), C-peptide, HbA1c, and insulin resistance (HOMA-IR)], blood lipids, and serum osteocalcin (OCN) levels [total osteocalcin (tOCN) and uncarboxylated osteocalcin (uOCN)] were compared with sex, menopausal status, and glucose tolerance status. Results: No significant difference was noted in the tOCN and uOCN levels concerning gender and menopausal status. tOCN was negatively correlated with BMI, waist circumference, BFP, and fat mass in patients with normal glucose tolerance (p<0.05) and premenopausal women (p<0.05). Besides, tOCN was negatively correlated with BFP and fat mass in patients with prediabetes (p<0.05) and positively correlated with fasting insulin levels and HOMA-IR in the prediabetes group (p<0.05). Conclusion: Our findings revealed no significant difference in tOCN and uOCN levels regarding sex, menopausal status or glucose tolerance. The likelihood of a more limited role and complex regulation of OCN-glucose homeostasis link in humans should be considered.

Anahtar Kelimeler

• Osteocalcin
• Diabetes Mellitus
• Type 2
• Adiposity
• Glucose Tolerance Test
• Menopause

Kaynakça

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