Glioblastome Multiforme Epidemiyolojisi, Tedavi Seçenekleri ve Sağ Kalım Süresi: Retrospektif Tek Merkezli Çalışma

Öz

Amaç: Glioblastoma multiforme (GBM), primer beyin tümörlerinin en sık görülenidir. Tedavisi ile ilgili çok sayıda klinik ve deneysel çalışma yapılmasına rağmen; GBM’in tedavi seçenekleri çok fazla değişmemiştir. Çalışmamız, GBM’li hastaların epidemiyolojisi, tedavi seçenekleri ve sağ kalım süreleri arasındaki ilişkiyi incelemek amacıyla planlandı. Gereç ve Yöntemler: Bu çalışmada, 2017-2019 yılları arasında Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Beyin ve sinir cerrahisi Anabilim Dalı’nda GBM tanısı alan 72 hasta retroprospektif olarak değerlendirilmiştir. Bu hastaların tedavi modaliteleri, epidemiyolojileri ve sağ kalım süreleri incelenmiştir. Bulgular: Hastaların 28’i kadın, 44’ü erkek olup, %55.6’sı 60 yaş üstüdür. Cinsiyet ile sağ kalım süresi arasındaki fark istatistiksel olarak anlamlı değildir (p=0.303>0.05). Yaş arttıkça sağ kalım süresinde %28,9 oranında azalış olduğu görülmüştür. GBM lokalizasyon olarak en sık temporopariyatel yerleşimli olduğu gözlenirken, tümör lokalizasyonu ile sağ kalım süresi arasında anlamlı fark görülmedi. Sonuç: Çalışmamızın sonucunda GBM’li hastalarda, yaşın ve kombine tedavi seçeneğinin önemli bir prognostik faktörler olduğu görülmüştür.

Anahtar Kelimeler

• Glioblastome Multiforme
• Radyoterapi
• Kemoterapi
• Epidemyoloji
• Ortalama sağkalım süresi

Epidemiology, Treatment Options and Survival Analysis of Glioblastoma Multiforme: A Retrospective Single Center Study

Öz

Aim: Glioblastoma multiforme (GBM) is the most common of primary brain tumors. Although there are many clinical and experimental studies about its treatment; options for treatment of GBM have not changed much. Our study was planned to examine the relationship between epidemiologies, treatment options and survival times of patients with GBM. Materials and Methods: In this study, 72 patients diagnosed with GBM between 2017-2019 in Zonguldak Bülent Ecevit University Faculty of Medicine Department of Brain and Neurosurgery were evaluated retroprospectively. These patients’ treatment modalities, epidemiologies and survival times were examined. Results: 28 of the patients are female, 44 of them are male, 55.6% of them are over the age of 60. The difference in survival. The relationship between gender and survival time is not revealing (p=0.303>0.05) It was observed that the survival time decreased by 28.9% with increasing age. While GBM was observed most frequently temporoparietal settlement as localization, there was no significant difference between tumor localization and survival time. Conclusion: As a result of our study, it was observed that age and combined treatment options are important prognostic factors in patients with GBM.

Anahtar Kelimeler

• Glioblastoma Multiforme
• Radiotherapy
• Chemotherapy
• Epidemiology
• Median survival time

Kaynakça

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