Durum Anksiyetesi Oral Glukoz Tolerans Test Sonuçlarını Etkiler mi?

Öz

Amaç: Bazı deneysel çalışmalarda, durum anksiyetesinin, katekol-o-metiltransferaz geni tarafından düzenlenen ve norepinefrin sekresyonunda artışa neden olan otonom sinir sisteminin sempatik etkisi tarafından düzenlendiği bildirmiştir. Bu nedenle, oral glukoz tolerans testi (OGTT) öncesi olan durum anksiyetesinin test sonuçlarına etkisini araştıran prospektif bir çalışma planladık. Gereç ve Yöntemler: Bu prospektif çalışma için OGTT endike olan hastalara test öncesinde, Durumluk Sürekli Kaygı Envanteri (STAI) TX-1 formu dolduruldu. OGTT’ler bu çalışma sırasında aynı hemşire tarafından ve aynı test odasında yapıldı. STAI TX-1 formu 20 maddeden oluşmakta ve bu maddelerin her biri 1’den 4’e kadar değişen skorlara sahipti.Bulgular: OGTT yapılan ve STAI TX-1 formunu dolduran 516 hastayı çalışmamıza dahil ettik. Durum anksiyete skoru ile OGTT sonuçları arasında anlamlı bir ilişki bulunmadı. İkili karşılaştırmalar, evli grupta vücut kütle indeksinin ve bel çevresinin bekar gruba göre anlamlı olarak daha yüksek olduğunu gösterdi. Benzer şekilde, evli grupta OGTT sonrası diyabet tanı yüzdesi, bekar gruptan anlamlı derecede daha yüksekti. Sonuç: Çalışmamız, teste bağlı durum anksiyetesinin OGTT sonuçları üzerinde bir etkisi olmadığını gösterdi. Hastaların durum anksiyetesinin OGTT’den hemen önce değerlendirilmesi gerekmeyebilir; ancak, literatürde açıklandığı gibi, kronik anksiyetenin OGTT sonuçlarını etkileyebileceğini hatırlamakta fayda vardır. Kronik anksiyetenin OGTT’den önce değerlendirilmesinin gerekli olup olmadığını belirlemeye yardımcı olmak için randomize prospektif çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Oral glukoz tolerans testi
• durum anksiyetesi
• norepinefrinerjik sempatik aktivite

Does State Anxiety Affect the Outcome of an Oral Glucose Tolerance Test?

Öz

Aim: Some experimental studies reported that state anxiety is mediated by sympathetic effect of autonomic nervous system with an increase in norepinephrine secretion regulated by the catechol-omethyltransferase gene. We conducted a prospective study investigating the effect of state anxiety of the subjects prior to oral glucose tolerance test (OGTT) on the test outcomes. Material and Methods: State-Trait Anxiety Inventory (STAI) TX-1 form was given to the patients whom OGTT was indicated for this prospective study. OGTTs were performed by the same nurse and in the same test room during this study. STAI TX-1 form consisted 20 items and each one of them had weighted scores from 1 to 4. Results: We included 516 patients to whom OGTT was performed and who completed STAI TX-1 form. No significant association between state anxiety score and OGTT outcomes was found. Pairwise comparisons showed BMI and waist circumference in the group of married were significantly higher than those in the group of single. Similarly, the percentage of DM diagnosis following OGTT in the group of married was significantly higher than that in the group of single. Conclusion: Our study demonstrated that test-dependent state anxiety had no impact on OGTT outcomes. Evaluating state anxiety of the patients right before OGTT may not be required; however, as described in the literature, it is worthwhile to remember chronic anxiety could affect the outcomes of OGTT and a randomized prospective study is necessary to help determine if evaluating trait anxiety is required prior to OGTT.

Anahtar Kelimeler

• Oral glucose tolerance test
• state anxiety
• norepinephrinergic sympathetic activity

Kaynakça

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