Klinik Araştırma
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Üriner Taş Hastalığı Olan Hastalarda Malign Aritmi Riskinin Elektrokardiyografi Parametreleri ile Değerlendirilmesi

Yıl 2024, Cilt: 8 Sayı: 2, 129 - 134, 30.08.2024
https://doi.org/10.29058/mjwbs.1397031

Öz

Amaç: Yaşam boyu görülme sıklığı %10-15 olan ve 10 yıl içinde %50'ye varan nüks oranıyla üriner sistem taş hastalığı önemli bir komorbidite nedenidir. Son zamanlarda, üriner sistem taş hastalığının sadece böbrek taşı gelişimi ile sınırlı olmadığı, aynı zamanda kalp-damar hastalıkları ve diğer çeşitli hastalıklarla da bağlantılı olduğu yaygın olarak kabul edilmektedir. Malign aritmiler (ani kalp ölümü ve ventriküler aritmiler) koroner arter hastalığının sonuçlarıdır. Üriner sistem taş hastalığının koroner arter hastalığı için risk faktörü olduğunu gösteren çok sayıda çalışmaya rağmen bu hasta grubunda herhangi bir elektrokardiyografik parametre değerlendirilmemiştir.
Bu prospektif gözlemsel çalışma, üriner taş hastalığı olan hastalarda malign aritmiler için risk göstergesi olan ventriküler repolarizasyon parametrelerini elektrokardiyografi kullanarak değerlendirmeyi amaçlamaktadır.
Gereç ve Yöntem: Çalışmaya üriner sistem taşı hastalığı tanısı alan hastalar ve sağlıklı gönüllüler dahil edildi. Tüm hastalara 12 derivasyonlu elektrokardiyografi yapıldı. Elektrokardiyografiler QTc aralığı, QTc dağılımı, T tepe-uç aralığı ve Tp-e/QTc açısından değerlendirilerek kontrol grubuyla karşılaştırıldı.
Bulgular: Hasta ve kontrol grupları arasında QTc aralığı, QTc dağılımı, T tepe-uç aralığı ve Tp-e/QTc parametreleri karşılaştırıldığında istatistiksel olarak anlamlı bir fark bulunamadı.
Sonuç: Mevcut bilginin aksine bu çalışma, üriner taş hastalığı olan hastalarda malign aritmilerin normal popülasyondan anlamlı derecede farklı olmadığını buldu.

Kaynakça

  • 1. Wilcox CR, Whitehurst LA, Cook P, Somani BK. Kidney stone disease: an update on its management in primary care.Br J Gen Pract. 2020;70:205-6.
  • 2. Pak CY, Sakhaee K, Moe O, Preminger G M, Poindexter J R, Peterson RD,Pietrow P, Ekeruo W. Biochemical profile of stone-forming patients with diabetes mellitus. Urology 2003;61:523-27
  • 3. Zimmerer T, Weiss C, Hammes H P, Braun C, Hesse A, Alken P, Knoll T. Evaluation of urolithiasis: a link between stone formation and diabetes mellitus? Urol Int 2009;82:350-55.
  • 4. Domingos F, Serra A. Nephrolithiasis is associated with an increased prevalence of cardiovascular disease. Nephrol Dial Transplant. 2011;26:864-68.
  • 5. Kovacevic L, Lu H, Caruso JA, Kovacevic N, Lakshmanan Y. Urinary proteomics reveals association between pediatric nephrolithiasis and cardiovascular disease.Int Urol Nephrol. 2018;50:1949-54.
  • 6. Cosgun A, Oren H. Variation of the T-wave peak-end interval and heart rate variability values in healthy males and females at various hours of the same day, and relationship of them. J Arrhythm. 2020;36:118-26.
  • 7. Franz MR, Zabel M. Electrophysiological basis of QT dispersion measurements. Prog Cardiovasc Dis. 2000;42:311-24.
  • 8. Rosenthal TM, Masvidal D, Abi SFM, Bernard ML, Habit S, Polin GM,Rogers PA, Xue JQ, Morin DP. Optimal method of measuring the T-peak to T-end interval for risk stratification in primary prevention Europace. 2018;20: 698-705
  • 9. Ucar FM, Oztürk C, Yılmaztepe MA. Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with acute myocarditis. BMC Cardiovascular Disorders. 2019; 19: 1-7.
  • 10. Zehir R, Karabay CY, Kalaycı A, Akgün T, Kılıçgedik A, Kırma C. Evaluation of Tpe interval and Tpe/QT ratio in patients with slow coronary flow. Anatol J Cardiol. 2015; 15: 463-67
  • 11. Hocagil AC; Hocagil H. Evaluation of Electrocardiography Parameters in Renal Colic Patients Admitted to the Emergency Department. Eurasian J Emerg Med. 2022, 21.1: 68-72.
  • 12. Aksoydan E, Çakır N. Adölesanların beslenme alışkanlıkları, fiziksel aktivite düzeyleri ve vücut kitle indekslerinin değerlendirilmesi. Gulhane Medical Journal 2011; 53:264-270.
  • 13. Cheungpasitporn W, Thongprayoon C, Mao MA, O’Corragain OA, Edmonds PJ, Erickson SB. The Risk of Coronary Heart Disease in Patients with Kidney Stones: A Systematic Review and Meta-analysis. N Am J Med Sci. 2014;6:580-85.
  • 14. Peng JP, Zheng H. Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta- analysis. Medicine (Baltimore). 2017;96:e7898.
  • 15. Rule AD, Roger VL, Melton LJ, Bergstralh EJ, Li X, Peyser PA, Krambeck AE, Lieske JC. Kidney stones associate with increased risk for myocardial infarction. J Am Soc Nephrol 2010; 21: 1641-44.
  • 16. Khan SR, Rodriguez DE, Gower LB, Monga M. Association of Randall plaque with collagen fibers and membrane vesicles. J Urol. 2012;187:1094-100.
  • 17. Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ,Curhan GC. History of kidney stones and the risk of coronary heart disease. JAMA. 2013;310:408-15.
  • 18. Reiner AP, Kahn A, Eisner BH, Pletcher MJ, Sadetsky N, Williams OD, Polak JF, Jacobs Jr DR, Stoller ML.Kidney stone and subclinical atherosclerosis in young adults: The CARDIA study. J Urol.2011;185:920-25
  • 19. Shu X, Cai H, Xiang YB, Li H, Lipworth L, Miller NL, Zheng W, Shu XO, Hsi RS. Nephrolithiasis Among Middle Aged and Elderly Urban Chinese: A Report from Prospective Cohort Studies in Shanghai. J Endourol. 2017;31:1327-34
  • 20. Shadman A, Bastani B. Kidney Calculi: Pathophysiology and as a Systemic Disorder Iran J Kidney Dis. 2017;11:180-91.
  • 21. Luo W, Zhou Y, Gao C, Yan P, Xu L. Urolithiasis, Independent of Uric Acid, Increased Risk of Coronary Artery and Carotid Atherosclerosis: A Meta-Analysis of Observational Studies. Biomed Res Int. 2020;2020:1026240.
  • 22. Seyfeli E, Duru M, Kuvandik G, Kaya H, Yalcin F. Effect of obesity on P-wave dispersion and QT dispersion in women. Int J Obes (Lond). 2006;30:957-61.
  • 23. Straus SMJ, Kors JA, De Bruin ML, Van der Hooft CS, Hofman A, Heeringa J, Deckers JW, Kingma JH, Sturkenboom MCJM, Stricker BHCh, Witteman JCM. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006; 47: 362-67

Evaluation of the Risk of Malignant Arrhythmia Through Electrocardiography Parameters in Patients with Urinary Stone Disease

Yıl 2024, Cilt: 8 Sayı: 2, 129 - 134, 30.08.2024
https://doi.org/10.29058/mjwbs.1397031

Öz

Introduction: With a lifetime frequency of 10-15% and a recurrence rate of up to 50% within 10 years, urinary stone disease is a major cause of comorbidity. Recently, it has become widely recognized that urinary system stone disease is not only limited to kidney stone development but is also linked to cardiovascular disease and various other illnesses. Malignant arrhythmias (sudden cardiac death and ventricular arrhythmias) are consequences of coronary artery disease. Despite numerous studies demonstrating that urinary system stone disease is a risk factor for coronary artery disease, no electrocardiographic parameters have been evaluated in this patient group
This prospective observational study aims to assess ventricular repolarization parameters using electrocardiography, which are risk indicators for malignant arrhythmias in patients with urinary stones disease.
Materials and Methods The study included patients diagnosed with urinary stone disease and healthy volunteers. All patients underwent 12-lead electrocardiography. The electrocardiographys were evaluated for QTc interval, QTc dispersion, T peak-end interval, and Tp-e/QTc, and compared with the control group.
Results: When comparing the QTc interval, QTc dispersion, T peak-end interval, and Tp-e/QTc parameters between the patient and control groups, no statistically significant differences were found.
Conclusion: Contrary to existing knowledge, this study found that malignant arrhythmias in patients with urinary stone disease were not significantly different from the normal population.

Kaynakça

  • 1. Wilcox CR, Whitehurst LA, Cook P, Somani BK. Kidney stone disease: an update on its management in primary care.Br J Gen Pract. 2020;70:205-6.
  • 2. Pak CY, Sakhaee K, Moe O, Preminger G M, Poindexter J R, Peterson RD,Pietrow P, Ekeruo W. Biochemical profile of stone-forming patients with diabetes mellitus. Urology 2003;61:523-27
  • 3. Zimmerer T, Weiss C, Hammes H P, Braun C, Hesse A, Alken P, Knoll T. Evaluation of urolithiasis: a link between stone formation and diabetes mellitus? Urol Int 2009;82:350-55.
  • 4. Domingos F, Serra A. Nephrolithiasis is associated with an increased prevalence of cardiovascular disease. Nephrol Dial Transplant. 2011;26:864-68.
  • 5. Kovacevic L, Lu H, Caruso JA, Kovacevic N, Lakshmanan Y. Urinary proteomics reveals association between pediatric nephrolithiasis and cardiovascular disease.Int Urol Nephrol. 2018;50:1949-54.
  • 6. Cosgun A, Oren H. Variation of the T-wave peak-end interval and heart rate variability values in healthy males and females at various hours of the same day, and relationship of them. J Arrhythm. 2020;36:118-26.
  • 7. Franz MR, Zabel M. Electrophysiological basis of QT dispersion measurements. Prog Cardiovasc Dis. 2000;42:311-24.
  • 8. Rosenthal TM, Masvidal D, Abi SFM, Bernard ML, Habit S, Polin GM,Rogers PA, Xue JQ, Morin DP. Optimal method of measuring the T-peak to T-end interval for risk stratification in primary prevention Europace. 2018;20: 698-705
  • 9. Ucar FM, Oztürk C, Yılmaztepe MA. Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with acute myocarditis. BMC Cardiovascular Disorders. 2019; 19: 1-7.
  • 10. Zehir R, Karabay CY, Kalaycı A, Akgün T, Kılıçgedik A, Kırma C. Evaluation of Tpe interval and Tpe/QT ratio in patients with slow coronary flow. Anatol J Cardiol. 2015; 15: 463-67
  • 11. Hocagil AC; Hocagil H. Evaluation of Electrocardiography Parameters in Renal Colic Patients Admitted to the Emergency Department. Eurasian J Emerg Med. 2022, 21.1: 68-72.
  • 12. Aksoydan E, Çakır N. Adölesanların beslenme alışkanlıkları, fiziksel aktivite düzeyleri ve vücut kitle indekslerinin değerlendirilmesi. Gulhane Medical Journal 2011; 53:264-270.
  • 13. Cheungpasitporn W, Thongprayoon C, Mao MA, O’Corragain OA, Edmonds PJ, Erickson SB. The Risk of Coronary Heart Disease in Patients with Kidney Stones: A Systematic Review and Meta-analysis. N Am J Med Sci. 2014;6:580-85.
  • 14. Peng JP, Zheng H. Kidney stones may increase the risk of coronary heart disease and stroke: A PRISMA-Compliant meta- analysis. Medicine (Baltimore). 2017;96:e7898.
  • 15. Rule AD, Roger VL, Melton LJ, Bergstralh EJ, Li X, Peyser PA, Krambeck AE, Lieske JC. Kidney stones associate with increased risk for myocardial infarction. J Am Soc Nephrol 2010; 21: 1641-44.
  • 16. Khan SR, Rodriguez DE, Gower LB, Monga M. Association of Randall plaque with collagen fibers and membrane vesicles. J Urol. 2012;187:1094-100.
  • 17. Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ,Curhan GC. History of kidney stones and the risk of coronary heart disease. JAMA. 2013;310:408-15.
  • 18. Reiner AP, Kahn A, Eisner BH, Pletcher MJ, Sadetsky N, Williams OD, Polak JF, Jacobs Jr DR, Stoller ML.Kidney stone and subclinical atherosclerosis in young adults: The CARDIA study. J Urol.2011;185:920-25
  • 19. Shu X, Cai H, Xiang YB, Li H, Lipworth L, Miller NL, Zheng W, Shu XO, Hsi RS. Nephrolithiasis Among Middle Aged and Elderly Urban Chinese: A Report from Prospective Cohort Studies in Shanghai. J Endourol. 2017;31:1327-34
  • 20. Shadman A, Bastani B. Kidney Calculi: Pathophysiology and as a Systemic Disorder Iran J Kidney Dis. 2017;11:180-91.
  • 21. Luo W, Zhou Y, Gao C, Yan P, Xu L. Urolithiasis, Independent of Uric Acid, Increased Risk of Coronary Artery and Carotid Atherosclerosis: A Meta-Analysis of Observational Studies. Biomed Res Int. 2020;2020:1026240.
  • 22. Seyfeli E, Duru M, Kuvandik G, Kaya H, Yalcin F. Effect of obesity on P-wave dispersion and QT dispersion in women. Int J Obes (Lond). 2006;30:957-61.
  • 23. Straus SMJ, Kors JA, De Bruin ML, Van der Hooft CS, Hofman A, Heeringa J, Deckers JW, Kingma JH, Sturkenboom MCJM, Stricker BHCh, Witteman JCM. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006; 47: 362-67
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kardiyoloji , Acil Tıp, Üroloji
Bölüm Araştırma Makalesi
Yazarlar

Hilal Hocagil 0000-0001-7314-752X

Abdullah Cüneyt Hocagil 0000-0002-1675-9754

Tuğba Akkaya Hocagil 0000-0003-3603-4491

Yayımlanma Tarihi 30 Ağustos 2024
Gönderilme Tarihi 28 Kasım 2023
Kabul Tarihi 9 Ağustos 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 8 Sayı: 2

Kaynak Göster

Vancouver Hocagil H, Hocagil AC, Akkaya Hocagil T. Evaluation of the Risk of Malignant Arrhythmia Through Electrocardiography Parameters in Patients with Urinary Stone Disease. Med J West Black Sea. 2024;8(2):129-34.

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