Neoadjuvan Kemoterapi Uygulanan Cerrahi Tedavi Görmüş Rektal Kanser Olgularında Beş Yıllık Takip Sonuçları

Yıl 2024, Cilt: 8 Sayı: 3, 283 - 290, 30.12.2024

Enes Şahin , Kazim Şahin , Ecenur Varol Fatih Koç , Haşim Köken Sertaç Ata Güler , Zafer Utkan

Öz

Amaç: Neoadjuvan tedavi alan rektum kanserli olgularda cerrahi yapılmadan izle ve bekle yönteminin mi yoksa operasyon yapılmasının mı
daha üstün olduğunu araştırmak istedik.
Gereç ve Yöntemler: 2018-2023 yılları arasında rektum tümörü tanısı alan 18 yaş üstü olguların klinik verileri retrospektif olarak analiz
edildi.
Bulgular: Neoadjuvan tedavi sonrasında bazı olgularda kitle tamamen kayboldu. Tüm olgular neoadjuvan tedavi sonrası opere edildi.
Neoadjuvan tedavi sonrası opere edilen 140 (80%) olguda adenokarsinom, 10 (5.5%) olguda normal kolon duvarı ve 20 (11%) olguda kronik
inflamasyon görüldü.
Sonuç: Rektum kanserli olgularda hastalığın evresine göre neoadjuvan tedavinin önemi gün geçtikçe daha iyi anlaşılmaktadır. Erken evre
rektum kanserinde erken cerrahi, olumlu sonuçları nedeniyle ilk basamak tedavi olarak önerilmektedir. Ancak lenf nodu metastazı olan lokal
ileri veya ileri evre rektum kanserlerinde cerrahi öncesi neoadjuvan tedavinin olgularda sağkalım ve cerrahi sonrası sağkalım açısından çok
daha faydalı olduğu yaygın olarak kabul görmektedir

Anahtar Kelimeler

Rektal kanser, neoadjuvan tedavi, izle ve bekle

Five Year Follow Up Results of Surgically Treated Rectal Cancer Case, Who Had Neoadjuvan Chemotheraph

Öz

Aim: We wanted to investigate whether the watch and wait method without surgery or surgery is superior in patients with rectal cancer
receiving neoadjuvant treatment.
Material and Methods: The clinical data of case above the age of 18 who were diagnosed with rectal tumors between 2018 and 2023 were
retrospectively analyzed.
Results: After neoadjuvant treatment, the mass disappeared completely in some case. All case were operated after neoadjuvant treatment.
Adenocarcinoma was seen in 140 (80%) case operated after neoadjuvant treatment, normal colon wall was seen in 10 (5.5%) case and
chronic inflammation was seen in 20 (11%) case.
Conclusion: The importance of neoadjuvant treatment according to the stage of the disease in case with rectal cancer is being better
understood day by day. Early surgery is recommended as the first-line treatment for early-stage rectal cancer due to its favorable outcomes.
However, it has been widely accepted that in locally advanced or advanced rectal cancers with lymph node metastasis, neoadjuvant
treatment before surgery is much more beneficial in terms of disease-free survival and survey after surgery

Anahtar Kelimeler

Rectal cancer, neoadjuvant therapy, watch and wait

Kaynakça

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