UYKU APNE SENDROMU OLAN HASTALARDA KARDİYOVASKÜLER HASTALIĞIN BİR GÖSTERGESİ OLAN AORTİK SERTLİĞİN EKOKARDİYOGRAFİ İLE DEĞERLENDİRİLMESİ

Öz

Amaç: Uyku apne sendromu; uyku boyunca üst
hava yollarının tekrarlayıcı şekilde tıkanıklığı ile
seyreden ve gün boyunca aşırı uyuklama şikayetine
neden olan bir hastalıktır. Arteriyel sertlik olumsuz
kardiyovasküler olaylarla ilişki olup birçok
çalışmada kardiyovasküler olaylara bağlı gelişen
mortalite ve morbiditenin erken belirleyicisi olarak
kullanılmaktadır.Biz bu çalışmamızda uyku apne
sendromlu hastalarda arteriyel sertliğin göstergesi
olan aort gerilimi ve esneyebilirliğini
ekokardiyografi yöntemi değerlendirmeyi
amaçladık.

Gereç ve yöntemler: Çalışmaya uyku apne
sendromu olup eşlik eden hastalığı olmayan 30
hasta ve 30 sağlıklı kontrol alındı. Tüm hastalara,
aortik sertlik hesaplanmak üzere ekokardiyografi
yapıldı ve değerler gruplar arasında karşılaştırıldı.
Bulgular: Hastaların yaş ve cinsiyetleri arasında
İstatiksel fark saptanmadı. Hastaların
ekokardiyografik parametrelerinden ejeksiyon
fraksiyonu, interventriküler septum ve posterior
duvar kalınlığı arasında gruplar arasında istatiksel
fark saptanmadı. Aort gerilimi UAS’u olan
hastalarda kontrol grubuna göre daha yüksek olarak
saptandı (8.64±3.41 ve 5.92±2.43, p=0.024).
Ayrıca, aort esneyebilirliği uyku apne sendromu
olan hastalarda kontrol grubuna göre daha düşük
olarak saptandı (2.30±1.98 ve 3.35±1.38, p=0.021).

Sonuç: Uyku apne sendromu olup eşlik eden
hastalığı olmayan hastalarda aortik sertlik artmış ve
aortik esneyebilirlik azalmıştır. Uyku apne
sendromu olan hastalarda transtorasik
ekokardiyografi arteriyel sertlik kolayca
değerlendirilebilir ve risk faktörlerine yönelik daha
yoğun tedavi ile kardiyovasküler hastalıklar ve
mortalitede azalma sağlanabilir.

Anahtar Kelimeler

• Uyku apne sendromu
• aort sertliği
• kardiyovasküler hastalık

Assesment of Aortic Stiffness as an Indicator of Cardiovascular Disease in Patients with Obstructive Sleep Apnea by using Echocardiography

Öz

Aim:Obstructive characterized with intermittant obstruction of upper air tracts and leading to somnolence during all day. Aortic stiffness is associated with poor cardiovascular outcome and an early indicator of mortality and morbidity. In the present study we aimed to investigate aortic stiffness and aortic dispensability in OSAS patients. Material and methods: We selected 30 obstructive apnea syndrome patients without co-morbidities and 30 healthy individuals. All patients underwent echocardiography to measure aortic stiffness and compared to between groups. Results: There is no difference in term of age and sex in two groups. There were no difference in ejection fraction, thickness of interventiculer septum and posterior wall in between groups. Aortic strain was higher in OSAS patients compared to healthy individuals (8.64±3.41 and 5.92±2.43, p=0.024). Also, aortic dispensability was lower in OSAS patients than those with control groups (2.30±1.98 and 3.35±1.38, p=0.021). Conclusion: Aortic stiffness was increased where as aortic dispensability was decreased in obstructive sleep apnea patients without co-morbidities. Arterial stiffness could be easily evaluated by transthoracic echocardiography in OSAS patients and these patients should be evaluated in detail to follow up and threat in terms of cardiovascular disease

Anahtar Kelimeler

• Obstructive sleep apnea
• aortic stiffness
• cardiovascular disease

Kaynakça

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