Evaluation of Neutrophil to Lymphocyte Ratio and Mean Platelet Volume in Inactive Hepatitis B Carriers

Öz

Aim: The aim of this study was to investigate the neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) levels in children with inactive hepatitis B virus (HBV) carriers and to evaluate the possible association between NLR, MPV and inflammation status in HBV infection.

Material and Method: Thirty inactive HBV carrier children and 32 age and gender matched healthy controls were enrolled as study group. Complete blood count parameters including white blood count, absolute neutrophil count and lymphocyte count, neutrophil to lymphocyte ratio and mean platelet volume were assessed in both study and the control groups.

Results: There was no significant difference in the mean age of inactive HBV carriers (11.9±3.4 years) and the control subjects (11.0±2.7 years) (p=0.25).  No significant differences were found in NLR (2.90±3.24 and 1.74±0.87, respectively, p=0.82) and MPV levels (7.9±1.0fL and 8.0±1.2fL, respectively, p=0.86) between inactive HBV carriers and the controls. MPV was found to be inversely correlated with platelet count in both patients and the control groups (r=-0.44, p=0.01; r=-0.36, p=0.04, respectively). A positive correlation was found between NLR and MPV (r=0.41, p=0.03) in patient group.

Conclusion: NLR and MPV levels were not different in inactive HBV carrier children compared to the controls. Our results suggest that NLR and MPV values may not be appropriate for determining of chronicity and inflammation status in chronic HBV infection.

Key words: Hepatitis B, chronic, neutrophil to lymphocyte ratio, mean platelet volume

Anahtar Kelimeler

• Hepatitis B, chronic, neutrophil to lymphocyte ratio, mean platelet volume

İnaktif Hepatit B Taşıyıcılarında Nötrofil Lenfosit Oranı ve Ortalama Trombosit Hacminin Değerlendirilmesi

Öz

Amaç: Bu çalışmanın amacı inaktif Hepatit B virüs (HBV) taşıyıcılarında nötrofil lenfosit oranı (NLO) ile ortalama trombosit hacmi (MPV) değerlerini araştırmak ve HBV enfeksiyonunda NLO ve MPV ile inflamasyon durumu arasındaki ilişkiyi değerlendirmektir. 

Gereç ve Yöntem: Otuz inaktif hepatit B virüs taşıyıcısı ve yaş ve cinsiyet yönünden hasta grubu ile uyumlu 32 sağlıklı çocuk kontrol grubuna dahil edildi. Hem çalışma hem de kontrol grubunda beyaz küre sayısı, mutlak nötrofil ve mutlak lenfosit sayısı, NLO ve MPV’yi içeren tam kan sayımı parametreleri değerlendirildi.

Bulgular: İnaktif HBV taşıyıcılar (11.9±3.4 yaş) ile kontrol grubu (11.0±2.7 yaş) arasında yaş ortalamaları yönünden fark yoktu (p=0.25). İnaktif HBV taşıyıcılar ile kontrol grubu arasında NLO (sırasıyla 2.90±3.24 ve 1.74±0.87, p=0.82) ve MPV değerleri (sırasıyla 7.9±1.0 fL ve 8.0±1.2 fL, p=0,86) yönünden de fark saptanmadı. Hem hasta hem de kontrol grubunda MPV ile trombosit sayısı arasında negatif korelasyon saptandı (sırasıyla r=-0.44, p=0.01; r=-0.36, p=0.04). Hasta grubunda MPV ile NLO arasında pozitif korelasyon saptandı (r=0.41, p=0.03).

Sonuç: İnaktif HBV taşıyıcılar ile kontroller karşılaştırıldığında NLO ve MPV değerleri farklı değildi. Bizim sonuçlarımız kronik HBV infeksiyonunda kronikleşme ve inflamasyon durumunun belirlenmesinde NLO ve MPV değerlerinin uygun olmayabileceğini düşündürmektedir.

Anahtar kelimeler: Hepatit B, kronisite, nötrofil-lenfosit oranı, ortalama trombosit hacmi

Anahtar Kelimeler

• Hepatit B, kronisite, nötrofil-lenfosit oranı, ortalama trombosit hacmi

Kaynakça

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