Sistemik İsotretionin Tedavisi Alan Akne Vulgarisli Hastalarda Hematolojik ve İnflamatuar Parametrelerin Değerlendirilmesi

Öz

Amaç: İsotretinoin sentetik vitamin A analoğudur. Orta ve şiddetli akne vulgariste 0.5-2mg/kg /gün dozunda 4-5 ay süreyle kullanılır. Bu çalışmada oral isotretinoin tedavisi alan akne vulgarisli hastalarda hematolojik ve inflamatuar parametrelerin retrospektif olarak değerlendirilmesi amaçlanmıştır.

Metot: Çalışmaya dermatoloji polikliniğine başvuran ve akne vulgaris tanısıyla oral isotretinoin tedavisi başlanan 352 hasta alındı. Hastaların tedavi öncesi ve tedavi başlangıcından 4 ay son-raki hematolojik ve inflamatuar parametreleri (hemoglobin, hematokrit, trombosit, ortalama trombosit hacmi, lökosit, eritrosit, nötrofil, lenfosit, monosit, eozinofil, bazofil, nötrofil /bazofil, trombosit/lenfosit, RDW, PCT, PDW) retrospektif olarak incelendi.

Bulgular: Tedaviden sonra lökosit, nötrofil ve nötrofil lenfosit oranına (NLO) seviye-lerinde istatistiksel olarak anlamlı bir azalma saptandı. Trombosit ve prokalsitonin (PCT) düzeylerinde istatistiksel olarak anlamlı bir artış saptandı.

Sonuç: Çalışmamızda saptadığımız isotreinoin tedavi sonrası inflamatuar belirteçlerinden NLR düşme akne de isotretinoin tedavisinin antienflamatuar etkisini desteklemektedir. Belirgin olarak trombosit yuksekliği olan veya lökosit düşüklüğü olan hastalarda yakın takip edilmelidir.

Anahtar Kelimeler

• Isotretinoin,acne vulgaris,inflamatuvar parametreler

Assessment of Hematological and Inflammatory Parameters in Patients Receiving Isotretinoin Therapy for Acne Vulgaris

Öz

Objectives:Isotretinoin (ISO) is a synthetic analog of vitamin A used at the doses of 0.5–2 mg/kg for four to five months in the treatment of moderate to severe acne vulgaris. In the present study, both hematological and inflammatory parameters were retrospectively assessed in patients receiving ISO therapy for acne vulgaris.

Method: This study included 352 patients who were admitted to the Dermatology Clinic and received oral ISO for the treatment of acne vulgaris were included in the study. Each patient’s hematological and inflammatory parameters (hemoglobin, hematocrit, thrombocyte, mean platelet volume, leukocyte, erythrocyte, neutrophil, lymphocyte, monocyte, eosinophil, basophil, neutrophil/basophil, thrombocyte/lymphocyte, RDW, PCT and PDW) were evaluated before the treatment and retrospectively evaluated four months after the onset of treatment. 

Results: After treatment, a significant decrease was detected in the levels of leukocyte, neutrophil and neutrophil to lymphocyte ratio (NLR) (an indicator of inflammation), and a significant increase was detected in the levels of thrombocyte and procalcitonin (PCT).

Conclusion: In our study, isotretinoin inhibited the anti-inflammatory effect of isotretinoin treatment of acne in patients with NLR decline after treatment with inflammatory markers. Patients with markedly elevated platelet counts or low leukocyte counts should be closely monitored.

Anahtar Kelimeler

• Isotretinoin,acne vulgaris,inflammatory parameters

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