Crohn’s Disease and Membranous Glomerulonephritis Case Report

Öz

Inflammatory bowel diseases (IBD) are two different types of chronic noninfectious gastrointestinal inflammatory diseases, namely Crohn’s disease and Ulcerative colitis. Renal involvement exists among the extraintestinal involvements of IBD. IBD renal involvements are in the form of glomerulonephritis, tubulointerstitial nephritis, nephrolithiasis, and renal amyloidosis. In this article, a 79-year-old male patient who presented with nephrotic proteinuria was diagnosed with membranous glomerulonephritis by renal biopsy. In addition, this article aims to discuss the patient who was diagnosed with Crohn’s disease in intestinal biopsy taken with colonoscopy while also referring to relative literature.

Anahtar Kelimeler

• Proteinuria
• Inflammatory Bowel Disease
• Crohn’s Disease

Crohn Hastalığı ve Membranöz Glomerulonefrit Olgu Sunumu

Öz

İnflamatuar barsak hastalıkları (IBD) Crohn hastalığı ve Ülseratif kolit olmak üzere birbirinden faklı olan iki tip kronik noninfeksiyöz gastrointestinal inflamatuar hastalıktır. IBH ekstraintestinal tutulumları arasında renal tutulum olmaktadır. IBH renal tutulumlar, glomerulonefrit, tübulointerstisyel nefrit, nefrolitiyazis ve renal amiloidozis şeklinde olmaktadır. Bu makalede nefrotik proteinüri ile başvuran 79 yaşında erkek hastada renal biyopsi ile membranöz glomerulonefrit tanısı kondu. Ayrıca yapılan kolonoskopi ile alınan barsak biyopsisinde Crohn hastalığı tanısı konan hastayı literatür eşliğinde tartışmayı amaçladık.

Anahtar Kelimeler

• Crohn hastalığı
• Proteinüri
• İnflamatuar Barsak Hastalıkları

Kaynakça

1. Ambruzs JM, Larsen CP. Renal Manifestations of Inflammatory Bowel Disease. Rheum Dis Clin North Am 2018;44 (4): 699-714. https://doi.org/10.1016/j.rdc.2018.06.007
2. Braysh K, Geagea AG, Matar C, Rizzo M, Eid A, Massaad-Massade L, Mallat S. and Jurjus A. Kidney Manifestations of Inflammatory Bowel Diseases. Kidney Manifestations of Inflammatory Bowel Diseases. Open Journal of Gastroenterology, 2018;8(5): 172-191. https://doi.org/10.4236/ojgas.2018.85020
3. Corica D, Romano C. Renal involvement in inflammatory bowel diseases. Journal of Crohn’s and Colitis, 2016;10(2):226-235. https://doi.org/10.1093/ecco-jcc/jjv138
4. Jussi Pohjonen, Rakel Nurmi, Martti Metso, Pia Oksanen, Heini Huhtala, Ilkka Pörsti, Jukka Mustonen, Katri Kaukinen, Satu Mäkelä Inflammatory bowel disease in patients undergoing renal biopsies Clin Kidney J. 2019; 12(5): 645-651. https://doi.org/10.1093/ckj/sfz004
5. Ambruzs JM, Walker PD, Larsen CP. The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease. Clinical Journal of the American Society of Nephrology. 2014;9(2): 265-270. https://doi.org/10.2215/CJN.04660513
6. Momtaz M, Elaziz A, Fayed A. Patterns of renal involvement in a cohort of patients with inflammatory bowel disease in Egypt. Acta gastroenterol. belg, 2018;81:381-386.
7. O’Loughlin EV, Robson L, Scott B, et al. Membranous glomerulonephritis in a patient with Crohn’s disease of the small bowel. J Pediatr Gastroenterol Nutr. 1985;4:135–139.
8. Granja E, Sacristán F, del Río Romero D, Trinidad JC. Association between membranous glomerulonephritis and Crohn’s disease. Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia, 2004;24(4):368-371.

9. Kallel L, Nijaa N, Fatma LB, Rais L, Mustapha NB, Matri S, Filali A. Familial cases of glomerulonephritis complicating Crohn’s disease. Journal of Crohn’s and Colitis, 2009;3(2):125-127.
10. Gupta A, Pendyala P, Arora P, Sitrin MD. Development of the nephrotic syndrome during treatment of Crohn’s disease with adalimumab. Journal of clinical gastroenterology, 2011;45(3):e30-e33.
11. Makhlogh A, and Fakheri H. Tırgar. “Membranous glomerulonephritis associated with ulcerative colitis.” 2008: 102-104.
12. Seona Park, Jaeyoung Chun, Kyung-Do Han, Hosim Soh, Kookhwan Choi, Ji Hye Kim, Jooyoung Lee, Changhyun Lee, Jong Pil Im, Joo Sung Kim. Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study. World J Gastroenterol. 2018; 24(42): 4798-4808. https://doi.org/10.3748/wjg.v24.i42.4798.
13. Lewis B, Mukewar S, Lopez R, Brzezinski A, Hall P, Shen B. Frequency and risk factors of renal insufficiency in inflammatory bowel disease inpatients. Inflammatory bowel diseases, 2013;19(9):1846-1851. https://doi.org/10.1097/MIB.0b013e31828a661e