Erkek Meme Kanseri: Tek Merkez Deneyimi

Öz

Amaç: Erkek meme kanseri (MBC), meme ve erkek kanserlerinin %1’inden azını oluşturan nadir bir hastalıktır. Bu yüzden MBC tedavi protokollerin çoğu kadınlar için meme kanseri tedavisi deneyiminden türetilmiştir. MBC, kadınlarda meme kanserinde olduğu gibi toplumsal farkındalık eksikliği nedeniyle genellikle ileri evrelerde saptanır. Bu çalışmada MBC ile ilgili klinik deneyimimizi güncel literatürle karşılaştırmayı amaçlanmıştır. Gereç ve Yöntem: Mersin Üniversitesi Tıp Fakültesi Hastanesinde Ocak 2008-Ocak 2018 tarihleri arasında meme kanseri tanısı alan 21 erkek hastanın dosyalarını retrospektif olarak incelenmiştir. Bulgular: Memede kitle nedeniyle kliniğimize 21 hasta başvurmuştur. Bu hastaların 17’sinde primer MBC ve 4’ün de ise metastatik meme kitlesi tespit edilmiştir. Primer MBC hastalarının 15’ine cerrahi tedavi uygulanırken ve 2 hasta neoadjuvan tedaviye yönlendirilmiştir. Çoğu cerrahi vakada basit mastektomi uygulanmıştır. 7 hasta direkt olarak aksiller lenf nodu diseksiyonu (ALND) uygulanırken ve 8 hastaya sentinel lenf nodu biyopsisi (SLNB) uygulanmıştır. 4 hastada SLNB pozitif gelmesi üzerine ALND uygulanmıştır. 24 aylık (6-96 ay arası) takipte hiçbir hastada lokal nüks gelişmediği gözlenmiştir. Sonuç: MBC’nin nadir olması, randomize klinik çalışmaları engellemektedir. MBC için klinik kararların çoğu, kadınlarda meme kanseri tedavisi deneyiminden türetilmiştir. MBC’yi daha iyi anlamak için daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler

• Aksiller Lenf Nodu Diseksiyonu
• Erkek Meme Kanseri
• Segmental Mastektomi
• Sentinel Lenf Nodu Biyopsisi

Male Breast Cancer: A Single-Center Experience

Öz

Objective: Male breast cancer (MBC) is a rare disease, accounting for less than 1% of breast and male cancers. Because of the low incidence, most of the clinical decisions for MBC have been derived from the experience of treatment of breast cancer in females. MBC is generally detected in advanced stages due to a lack of social awareness as it occurs in breast cancer in females. In this study, it was aimed to compare our clinical experience with MBC with current literature. Methods: This study retrospectively reviewed 21 men who were diagnosed with MBC between January 2008 and January 2018 at the Department of General Surgery of Mersin University School of Medicine, Mersin, Turkey. Results: Unilateral malign breast lesions were identified in 21 male patients that 17 are primary MBC and 4 metastatic breast lesions. 15 primary MBC patients underwent primary surgical treatment, and 2 patients were directed to neoadjuvant treatment. Simple mastectomies were performed in most surgical cases. 7 patients were directly addressed to axillary lymph node dissection (ALND), and sentinel lymph node biopsy (SLNB) was performed in 8 patients. 4 patients had tumor positivity in the settings of SLNB, and further ALND was performed subsequently in these cases. None of the patients developed local recurrence in the 24-month follow-up (range 6-96 months). Conclusion: The rarity of MBC precludes randomized clinical trials. Most of the clinical decisions for MBC have been derived from the experience of treatment of breast cancer in females. Further studies are needed to understand better MBC.

Anahtar Kelimeler

• Axillary Lymph Node Dissection
• Male Breast Cancer
• Segmental Mastectomy
• Sentinel Lymph Node Biopsy

Kaynakça

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