Medical Treatment in Covid-19: Changes in Post-treatment Laboratory Results and CT Findings

Öz

Objective: Today, the symptoms, imaging features and laboratory findings of the disease are known, but the treatment of the Coronavirus disease 2019 has not been clarified. In this study, we aim to investigate the efficacy of favipiravir in patients who do not need invasive mechanical ventilation, by examining the post-treatment laboratory and computed tomography findings compared to the hydroxychloroquine which removed from the treatment guide. Methods: In our study, 49 patients diagnosed with Coronavirus disease 2019 and treated with hydroxychloroquine and favipiravir were examined. The patients were divided into 3 groups according to their treatment modalities. The changes in the pre- and post-treatment laboratory findings and computed tomography imaging of the patients in these 3 groups were examined. Results:There was no statistically significant difference between the rates and types of lesion patterns observed on thorax computed tomography in the groups. The most common lesion pattern in each group was the presence of ground glass opacity + consolidation in 18 patients (81.8%) in the hydroxychloroquine group, 7 patients (70%) in the favipiravir group and 10 patients (58.8%) in the hydroxychloroquine + favipiravir group. In all 3 groups, there was a statistically significant improvement in C-reactive protein, ferritin, fibrinogen values and computed tomography scores after treatment and there was no statistically significant difference between drugs. Conclusion: In this study, we found no significant superiority of favipiravir in terms of changes in laboratory and computed tomography findings after treatment in Covid-19 patients who do not need intensive care compared to hydroxychloroquine.

Anahtar Kelimeler

• Severe Acute Respiratory Syndrome Coronavirus 2
• Favipiravir
• Computed Tomography
• Tomography Score

Covid-19'da Tıbbi Tedavi: Tedavi Sonrası Laboratuvar Sonuçlarında ve BT Bulgularında Değişiklikler

Öz

Amaç: Günümüzde, Koronavirüs hastalığı 2019’un semptomları, görüntüleme özellikleri ve laboratuvar bulguları bilinmektedir ancak hastalığın tedavisi netlik kazanmamıştır. Bu çalışmada, invaziv mekanik ventilasyona ihtiyaç duymayan hastalarda favipiravirin etkinliğini tedavi sonrası laboratuvar ve bilgisayarlı tomografi bulgularındaki değişimleri, tedavi kılavuzundan çıkarılan hidroksiklorokin ile karşılaştırarak incelemeyi amaçladık. Gereç ve Yöntem: Çalışmamızda Koronavirüs hastalığı 2019 tanısı konulan ve hidroksiklorokin ve favipiravir ile tedavi edilen 49 hasta incelendi. Hastalar tedavi şekillerine göre 3 gruba ayrıldı. Bu 3 gruptaki hastaların tedavi öncesi ve sonrası laboratuvar bulgularındaki ve bilgisayarlı tomografi görüntülemesindeki değişiklikler incelendi. Bulgular: Gruplarda, toraks bilgisayarlı tomografi tetkikinde izlenen lezyon paternlerinin oranları ve türleri arasında istatistiksel olarak anlamlı bir fark yoktu. Her bir grupta lezyon paterni olarak en sık hidroksiklorokin grubunda 18 hastada (%81.8), favipiravir grubunda 7 hastada (%70) ve hidroksiklorokin+favipiravir grubunda 10 hastada (%58.8) buzlu cam dansitesi+konsolidasyon varlığı izlendi. Her 3 grupta da C-reaktif protein, ferritin, fibrinojen değerlerinde ve bilgisayarlı tomografi skorlarında tedavi sonrası istatistiksel olarak anlamlı düzelme mevcuttu ve ilaçlar arasında istatistiksel olarak anlamlı bir fark yoktu. Sonuç: Bu çalışmada, yoğun bakıma ihtiyaç duymayan Koronavirüs hastalığı 2019 hastalarında hidroksiklorokine kıyasla tedavi sonrası laboratuvar ve bilgisayarlı tomografi bulgularındaki değişiklikler açısından favipiravirin anlamlı bir üstünlüğü bulunamamıştır.

Anahtar Kelimeler

• Şiddetli Akut Solunum Sendromu Koronavirüs 2
• Favipiravir
• Bilgisayarlı Tomografi
• Tomografi Skoru

Kaynakça

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