Duodenal bölge tutulumu ile seyreden mortal nötropenik enterokolit olgusu

Öz

Nötropenik enterokolit çoğunlukla akut lösemili hastalar gibi mukozal hasarı indükleme potansiyeli yüksek hastalığı olanları ve yoğun kemoterapötik rejimleri alan hastaları etkilemektedir. Burada kemoterapi devamında ateş, karın ağrısı, bulantı, kusma, karında şişkinlik, ishal, ağız içinde yara şikayetleri ile başvuran, batın BT’ de diffüz duodenum duvar kalınlaşması saptanan 34 yaşında akut lenfoblastik lösemi tanılı nötropenik enterokolit olgusu sunulmuştur. Olgumuzu sunmaya değer kılan duodenal bölge tutulumu ile seyreden nötropenik enterokolit olmasıdır.

Anahtar Kelimeler

• Akut lenfoblastik lösemi
• kemoterapi
• nötropenik enterokolit
• Duodenum

Mortal neutropenic enterocolitis case with duodenal involvement

Öz

Neutropenic enterocolitis mostly affects patients with disease with a high potential to induce mucosal injury, such as patients with acute leukemia, and patients receiving intensive chemotherapeutic regimens. Here, we present a 34-year-old neutropenic enterocolitis case diagnosed with acute lymphoblastic leukemia and diffuse duodenal wall thickening on abdominal CT, who presented with fever, abdominal pain, nausea, vomiting, abdominal distention, diarrhea, and mouth sores following chemotherapy. What makes our case worth presenting is neutropenic enterocolitis with duodenal involvement.

Anahtar Kelimeler

• Neutropenic enterocolitis
• acute lymphoblastic leukemia
• chemotherapy
• Duodenum

Kaynakça

1. Rodrigo P, Marcio N. Typhlitis (neutropenic enterocolitis) in patients with acute leukemia: a review. Expert Rev Hematol. 2017 Feb;10(2):169-174. https://doi.org/10.1080/17474086.20 17.1280389.
2. Batlle M, Vall-Llovera F, Bechini J, et al. Neutropenic enterocolitis in adult patients with acute leukemia or stem cell transplant recipients: study of 7 cases. Med Clin (Barc). 2007; 129(17): 660-3. https://doi.org/10.1157/13112098.
3. Cloutier RL. Neutropenic enterocolitis. Emerg Med Clin North Am. 2009 Aug;27(3):415-22. https://doi.org/10.1016/j. emc.2009.04.002.
4. Öncü S. Neutropenic Enterocolitis. Review. Klinik Dergisi 2009; 22(3): 75-8.
5. Rizzatti M, Brandalise SR, de Azevedo AC, Pinheiro VR, Aguiar Sdos S. Neutropenic enterocolitis in children and young adults with cancer: prognostic value of clinical and image findings. Pediatr Hematol Oncol. 2010 Sep;27(6):462-70. https://doi.org /10.3109/08880018.2010.489934.
6. Yuluğkural Z, Üçkardeş H, Mutlu B, Hacıhanefi oğlu A. Nötropenik enterokolit: olgu sunumu. Trakya Üniv Tıp Fak Derg. 2007; 24(2): 162-4.
7. Cardona Zorrilla AF, Reveiz Herault L, Casasbuenas A, Aponte DM, Ramos PL. Systematic review of case reports concerning adults suffering from neutropenic enterocolitis. Clin Transl Oncol. 2006; 8(1): 31-8. https://doi.org/10.1007/s12094-006-0092-y.
8. Davila ML. Neutropenic enterocolitis: current issues in diagnosis and management. Curr Infect Dis Rep. 2007; 9(2): 116-20. https://doi.org/10.1007/s11908-007-0006-3.

9. Dietrich CF, Hermann S, Klein S, Braden B. Sonographic signs of neutropenic enterocolitis. World J Gastroenterol. 2006; 12(9): 1397-402. https://doi.org/10.3748/wjg.v12.i9.1397.