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ANKİLOZAN SPONDİLİTTE GÜNCEL TEDAVİ SEÇENEĞİ: TÜMÖR NEKROZ FAKTÖR ALFA ANTAGONİSTLERİ

Yıl 2012, Cilt: 3 Sayı: 12, 39 - 47, 03.03.2015

Öz

Ankilozan spondilit (AS), aksiyal iskelet, entezis bölgeleri ve periferik eklemleri etkileyen kronik, sistemik, inflamatuar bir hastalıktır. AS tedavisinde farmakolojik tedavi yanı sıra eğitim ve fizik tedavi gibi farmakolojik olmayan tedavi metotları da uygulanmaktadır. Farmakolojik ajanlardan tümör nekroz faktör alfa (TNF-α) antagonistleri diğer tedavilere yanıt alınamayan hastalarda kullanılmaktadır. Bunlar infliksimab, etanersept, adalimumab ve golimumabdır. Bu ilaçlar hem klinik hem de laboratuar parametreleri üzerine etkinlik gösterebilmektedirler.
Ancak oluşabilecek yan etkiler nedeniyle dikkatli olunması ve hastaların düzenli takip edilmesi gerekmektedir.

Kaynakça

  • Van Der Linden S, Van Der Hejide D, Braun J Ankylosing spondylitis. In: Harris ED,
  • Budd RC, Frestein GS, Genovese MC, Sergent JS, Ruddy S, Sledge CB (Editors)
  • Kelley’s textbook of rheumatology, 7. Baskı, Philadelphia:Elsevier Saunders, 2005:
  • -1141.
  • Bal A, Unlu E, Bahar G, Aydog E, Eksioglu E, Yorgancioglu R.Comparison of serum
  • IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in
  • ankylosing spondylitis. Clin Rheumatol. 2007;26:211-5.
  • Reed MR, Taylor AL. Tumour necrosis factor inhibitors in ankylosing
  • spondylitis.Intern Med J. 2008;38:781-9.
  • Braun J, Sieper J. Ankylosing spondylitis.Lancet. 2007;369:1379-90.
  • Braun J, Van den Berg R, Baraliakos X, Boehm H, Burgos-Vargas R, Collantes-Estevez
  • E, Dagfinrud H, Dijkmans B, Dougados M, Emery P, Geher P, Hammoudeh M, Inman
  • RD, Jongkees M, Khan MA, Kiltz U, Kvien T, Leirisalo-Repo M, Maksymowych WP,
  • Olivieri I, Pavelka K, Sieper J, Stanislawska-Biernat E, Wendling D, Ozgocmen S, Van
  • Drogen C, Van Royen B, Van der Heijde D. 2010 update of the ASAS/EULAR
  • recommendations for the management of ankylosing spondylitis. AnnRheumDis.
  • ;70:896-904.
  • Van der Linden S. Issues in the treatment of ankylosing spondylitis with non-steroidal
  • anti-inflammatory drugs. Wien Med Wochenschr. 2008;158:195-9.
  • Poddubnyy D, Van der Heijde D. Therapeutic controversies in spondyloarthritis:
  • nonsteroidal anti-inflammatory drugs.Rheum Dis Clin North Am. 2012;38:601-11.
  • Bodur H, Sivas F, Yılmaz Ö, Özgöçmen S, Günaydın R, Kaya T Ataman Ş, Altan L,
  • Altay Z, Aydoğ E, Birtane M, Borman P, Soy Buğdaycı D, Bütün B, Çakırbay H,
  • Duruöz T, Gürer G, Hepgüler S, Kamanlı A, Kuru Ö, Küçükdeveci A, Nacır B, Ölmez
  • N, Rezvani A, Çörekçi Yanık B. Türkiye romatizma araştırma savaş derneği ankilozan
  • spondilit ulusal tedavi önerileri.Turk J Rheumatol. 2011;26:173-86.
  • Kabasakal Y, Kitapcioglu G, Yargucu F, Taylan A, Argin M, Gumusdis G. Efficacy of
  • SLZ and MTX (aloneorcombination) on thetreatment of active sacroiliitis in early
  • AS.Rheumatol Int. 2009;29:1523-7.
  • Khalessi AA, Oh BC, Wang MY. Medical management of ankylosing
  • spondylitis.Neurosurg Focus. 2008;24:E4.
  • Baraliakos X, Braun J. Biologic therapies for spondyloarthritis: what is new?Curr
  • Rheumatol Rep. 2012;14:422-7.
  • Machado MA, Barbosa MM, Almeida AM, de Araujo VE, Kakehasi AM, Andrade EI,
  • Cherchiglia ML, Acurciof de A. Treatment of ankylosing spondylitis with TNF
  • blockers: a meta-analysis.Rheumatol Int. 2013;33:2199-213.
  • Van der Heijde D, Sieper J, Maksymowych WP, Dougados M, Burgos-Vargas R,
  • Landewe R, Rudwaleit M, Braun J; Assessment of Spondylo Arthritis international
  • Society. 2010 Up date of the international ASAS recommendations for the use of anti-
  • TNF agents in patients with axial spondyloarthritis.Ann Rheum Dis. 2011;70:905-8.
  • Brandt J, Marzo-Ortega H, Emery P. Ankylosing spondylitis: new treatment modalities.
  • Best Pract Res Clin Rheumatol. 2006;20:559-70.
  • Braun J, Brandt J, Listing J, Zink A, Alten R, Golder W, Gromnica-Ihle E, Kellner H,
  • Krause A, Schneider M, Sörensen H, Zeidler H, Thriene W, Sieper J. Treatment of
  • active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial.
  • Lancet. 2002;359:1187-93.
  • Van der Heijde D, Dijkmans B, Geusens P, Sieper J, DeWoody K, Williamson P, Braun
  • J; Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy
  • Study Group. Efficacy and safety of infliximab in patients with ankylosing spondylitis:
  • results of a randomized, placebo-controlled trial (ASSERT). Arthritis Rheum.
  • ;52:582-91.
  • Braun J, Baraliakos X, Listing J, Fritz C, Alten R, Burmester G, Krause A, Schewe S,
  • Schneider M, Sörensen H, Zeidler H, Sieper J. Persistent clinical efficacy and safety of
  • anti-tumour necrosis factor alpha therapy with infliximab in patients with ankylosing
  • spondylitis over 5 years: evidence for different types of response.Ann Rheum Dis.
  • ;67:340-5.
  • Baraliakos X, Listing J, Fritz C, Haibel H, Alten R, Burmester GR, Krause A, Schewe
  • S, Schneider M, Sörensen H, Schmidt R, Sieper J, Braun J.Persistent clinical efficacy
  • and safety of infliximab in ankylosing spondylitis after 8 years-early clinical response
  • predicts long-term outcome. Rheumatology (Oxford). 2011;50:1690-9.
  • Braun J, Breban M, Maksymowych WP. Therapy for ankylosing spondylitis: new
  • treatment modalities. Best Pract Res Clin Rheumatol. 2002;16:631-51.
  • De Stefano R, Frati E, De Quattro D, Menza L, Manganelli S. Low doses of etanercept
  • can be effective to maintain remission in ankylosing spondylitis patients.Clin
  • Rheumatol. 2013. [Epubahead of print]
  • Gorman JD, Sack KE, Davis JC Jr. Treatment of ankylosing spondylitis by inhibition of
  • tumor necrosis factor alpha. N Engl J Med. 2002;346:1349-56
  • Brandt J, Khariouzov A, Listing J, Haibel H, Sörensen H, Grassnickel L, Rudwaleit M,
  • Sieper J, Braun J. Six-month results of a double-blind, placebo-controlled trial of
  • etanercept treatment in patients with active ankylosing spondylitis.Arthritis Rheum.
  • ;48:1667-75.
  • Baraliakos X, Haibel H, Fritz C, Listing J, Heldmann F, Braun J, Sieper J. Long-term
  • outcome of patients with active ankylosing spondylitis with etanercept-sustaine
  • defficacy and safety after seven years. Arthritis Res Ther. 2013;15(3):R67.
  • Zochling J. Assessment and treatment of ankylosing spondylitis: current status and
  • future directions.Curr Opin Rheumatol. 2008;20(4):398-403.
  • Braun J, Sieper J. Biological therapies in the spondyloarthritides-the current
  • state.Rheumatology (Oxford). 2004;43:1072-84.
  • Van der Heijde D, Schiff MH, Sieper J, Kivitz AJ, Wong RL, Kupper H, Dijkmans BA,
  • Mease PJ, Davis JC Jr; ATLAS Study Group.Adalimumab effectiveness for the
  • treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results
  • from the ATLAS trial. Ann Rheum Dis. 2009;68:922-9.
  • Sieper J, Van der Heijde D, Dougados M, Mease PJ, Maksymowych WP, Brown MA,
  • Arora V, Pangan AL. Efficacy and safety of adalimumab in patients with nonradiographic
  • axial spondyloarthritis: results of a randomised placebo-controlled trial
  • (ABILITY-1).Ann Rheum Dis. 2013;72:815-22.
  • Sieper J, Van der Heijde D, Dougados M, Brown LS, Lavie F, Pangan AL. Early
  • response to adalimumab predicts long-term remission through 5 years of treatment in
  • patients with ankylosing spondylitis. Ann Rheum Dis. 2012;71:700-6.
  • Mittal M, Raychaudhuri SP. Golimumab and certolizumab: the two new anti-tumor
  • necrosis factor kids on the block. Indian J Dermatol Venereol Leprol. 2010;76:602-8.
  • Keystone EC, Genovese MC, Hall S, Miranda PC, Bae SC, Palmer W, Wu Z, Xu S,
  • Hsia EC. Golimumab in patients with active rheumatoid arthritis despite
  • methotrexatetherapy: results through 2 years of the GO-FORWARD study extension. J
  • Rheumatol. 2013;40:1097-103.
  • Inman RD, Davis JC, Heijde DV, Diekman L, Sieper J, Kim SI, Mack M, Han J,
  • Visvanathan S, Xu Z, Hsu B, Beutler A, Braun J. Efficacy and safety of golimumab in
  • patients with ankylosing spondylitis: results of a randomized, double-blind, placebocontrolled,
  • phase III trial. Arthritis Rheum. 2008;58:3402-12.
  • Braun J, Baraliakos X, Hermann KG, Van der Heijde D, Inman RD, Deodhar AA,
  • Baratelle A, Xu S, Xu W, Hsu B. Golimumab reduces spinal inflammation in
  • ankylosing spondylitis: MRI results of the randomised, placebo-controlled GO-RAISE
  • study.Ann Rheum Dis. 2012;71:878-84.

Current Treatment Option in Ankylosing Spondylitis: Tumor Necrosis Factor Alpha Antagonists

Yıl 2012, Cilt: 3 Sayı: 12, 39 - 47, 03.03.2015

Öz

Ankylosing spondylitis (AS) is a chronic, systemic, inflammatory disease that particularly involves axial skeleton, enthesis regions and peripheral joints. The pharmacological therapy as well as nonpharmacological therapy methods such as patient education and physical therapy are also applied in thetreatment of AS. Tumor necrosis factor alpha (TNF-α) antagonists, the pharmacological agents, are used in patients who fail to respond to other treatments. These are infliximab, etanercept, adalimumab, and golimumab. These drugs can show an efficiency on
both clinical and laboratory parameters. However, the side effects that may occur due caution and patients should be monitored regularly.

Kaynakça

  • Van Der Linden S, Van Der Hejide D, Braun J Ankylosing spondylitis. In: Harris ED,
  • Budd RC, Frestein GS, Genovese MC, Sergent JS, Ruddy S, Sledge CB (Editors)
  • Kelley’s textbook of rheumatology, 7. Baskı, Philadelphia:Elsevier Saunders, 2005:
  • -1141.
  • Bal A, Unlu E, Bahar G, Aydog E, Eksioglu E, Yorgancioglu R.Comparison of serum
  • IL-1 beta, sIL-2R, IL-6, and TNF-alpha levels with disease activity parameters in
  • ankylosing spondylitis. Clin Rheumatol. 2007;26:211-5.
  • Reed MR, Taylor AL. Tumour necrosis factor inhibitors in ankylosing
  • spondylitis.Intern Med J. 2008;38:781-9.
  • Braun J, Sieper J. Ankylosing spondylitis.Lancet. 2007;369:1379-90.
  • Braun J, Van den Berg R, Baraliakos X, Boehm H, Burgos-Vargas R, Collantes-Estevez
  • E, Dagfinrud H, Dijkmans B, Dougados M, Emery P, Geher P, Hammoudeh M, Inman
  • RD, Jongkees M, Khan MA, Kiltz U, Kvien T, Leirisalo-Repo M, Maksymowych WP,
  • Olivieri I, Pavelka K, Sieper J, Stanislawska-Biernat E, Wendling D, Ozgocmen S, Van
  • Drogen C, Van Royen B, Van der Heijde D. 2010 update of the ASAS/EULAR
  • recommendations for the management of ankylosing spondylitis. AnnRheumDis.
  • ;70:896-904.
  • Van der Linden S. Issues in the treatment of ankylosing spondylitis with non-steroidal
  • anti-inflammatory drugs. Wien Med Wochenschr. 2008;158:195-9.
  • Poddubnyy D, Van der Heijde D. Therapeutic controversies in spondyloarthritis:
  • nonsteroidal anti-inflammatory drugs.Rheum Dis Clin North Am. 2012;38:601-11.
  • Bodur H, Sivas F, Yılmaz Ö, Özgöçmen S, Günaydın R, Kaya T Ataman Ş, Altan L,
  • Altay Z, Aydoğ E, Birtane M, Borman P, Soy Buğdaycı D, Bütün B, Çakırbay H,
  • Duruöz T, Gürer G, Hepgüler S, Kamanlı A, Kuru Ö, Küçükdeveci A, Nacır B, Ölmez
  • N, Rezvani A, Çörekçi Yanık B. Türkiye romatizma araştırma savaş derneği ankilozan
  • spondilit ulusal tedavi önerileri.Turk J Rheumatol. 2011;26:173-86.
  • Kabasakal Y, Kitapcioglu G, Yargucu F, Taylan A, Argin M, Gumusdis G. Efficacy of
  • SLZ and MTX (aloneorcombination) on thetreatment of active sacroiliitis in early
  • AS.Rheumatol Int. 2009;29:1523-7.
  • Khalessi AA, Oh BC, Wang MY. Medical management of ankylosing
  • spondylitis.Neurosurg Focus. 2008;24:E4.
  • Baraliakos X, Braun J. Biologic therapies for spondyloarthritis: what is new?Curr
  • Rheumatol Rep. 2012;14:422-7.
  • Machado MA, Barbosa MM, Almeida AM, de Araujo VE, Kakehasi AM, Andrade EI,
  • Cherchiglia ML, Acurciof de A. Treatment of ankylosing spondylitis with TNF
  • blockers: a meta-analysis.Rheumatol Int. 2013;33:2199-213.
  • Van der Heijde D, Sieper J, Maksymowych WP, Dougados M, Burgos-Vargas R,
  • Landewe R, Rudwaleit M, Braun J; Assessment of Spondylo Arthritis international
  • Society. 2010 Up date of the international ASAS recommendations for the use of anti-
  • TNF agents in patients with axial spondyloarthritis.Ann Rheum Dis. 2011;70:905-8.
  • Brandt J, Marzo-Ortega H, Emery P. Ankylosing spondylitis: new treatment modalities.
  • Best Pract Res Clin Rheumatol. 2006;20:559-70.
  • Braun J, Brandt J, Listing J, Zink A, Alten R, Golder W, Gromnica-Ihle E, Kellner H,
  • Krause A, Schneider M, Sörensen H, Zeidler H, Thriene W, Sieper J. Treatment of
  • active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial.
  • Lancet. 2002;359:1187-93.
  • Van der Heijde D, Dijkmans B, Geusens P, Sieper J, DeWoody K, Williamson P, Braun
  • J; Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy
  • Study Group. Efficacy and safety of infliximab in patients with ankylosing spondylitis:
  • results of a randomized, placebo-controlled trial (ASSERT). Arthritis Rheum.
  • ;52:582-91.
  • Braun J, Baraliakos X, Listing J, Fritz C, Alten R, Burmester G, Krause A, Schewe S,
  • Schneider M, Sörensen H, Zeidler H, Sieper J. Persistent clinical efficacy and safety of
  • anti-tumour necrosis factor alpha therapy with infliximab in patients with ankylosing
  • spondylitis over 5 years: evidence for different types of response.Ann Rheum Dis.
  • ;67:340-5.
  • Baraliakos X, Listing J, Fritz C, Haibel H, Alten R, Burmester GR, Krause A, Schewe
  • S, Schneider M, Sörensen H, Schmidt R, Sieper J, Braun J.Persistent clinical efficacy
  • and safety of infliximab in ankylosing spondylitis after 8 years-early clinical response
  • predicts long-term outcome. Rheumatology (Oxford). 2011;50:1690-9.
  • Braun J, Breban M, Maksymowych WP. Therapy for ankylosing spondylitis: new
  • treatment modalities. Best Pract Res Clin Rheumatol. 2002;16:631-51.
  • De Stefano R, Frati E, De Quattro D, Menza L, Manganelli S. Low doses of etanercept
  • can be effective to maintain remission in ankylosing spondylitis patients.Clin
  • Rheumatol. 2013. [Epubahead of print]
  • Gorman JD, Sack KE, Davis JC Jr. Treatment of ankylosing spondylitis by inhibition of
  • tumor necrosis factor alpha. N Engl J Med. 2002;346:1349-56
  • Brandt J, Khariouzov A, Listing J, Haibel H, Sörensen H, Grassnickel L, Rudwaleit M,
  • Sieper J, Braun J. Six-month results of a double-blind, placebo-controlled trial of
  • etanercept treatment in patients with active ankylosing spondylitis.Arthritis Rheum.
  • ;48:1667-75.
  • Baraliakos X, Haibel H, Fritz C, Listing J, Heldmann F, Braun J, Sieper J. Long-term
  • outcome of patients with active ankylosing spondylitis with etanercept-sustaine
  • defficacy and safety after seven years. Arthritis Res Ther. 2013;15(3):R67.
  • Zochling J. Assessment and treatment of ankylosing spondylitis: current status and
  • future directions.Curr Opin Rheumatol. 2008;20(4):398-403.
  • Braun J, Sieper J. Biological therapies in the spondyloarthritides-the current
  • state.Rheumatology (Oxford). 2004;43:1072-84.
  • Van der Heijde D, Schiff MH, Sieper J, Kivitz AJ, Wong RL, Kupper H, Dijkmans BA,
  • Mease PJ, Davis JC Jr; ATLAS Study Group.Adalimumab effectiveness for the
  • treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results
  • from the ATLAS trial. Ann Rheum Dis. 2009;68:922-9.
  • Sieper J, Van der Heijde D, Dougados M, Mease PJ, Maksymowych WP, Brown MA,
  • Arora V, Pangan AL. Efficacy and safety of adalimumab in patients with nonradiographic
  • axial spondyloarthritis: results of a randomised placebo-controlled trial
  • (ABILITY-1).Ann Rheum Dis. 2013;72:815-22.
  • Sieper J, Van der Heijde D, Dougados M, Brown LS, Lavie F, Pangan AL. Early
  • response to adalimumab predicts long-term remission through 5 years of treatment in
  • patients with ankylosing spondylitis. Ann Rheum Dis. 2012;71:700-6.
  • Mittal M, Raychaudhuri SP. Golimumab and certolizumab: the two new anti-tumor
  • necrosis factor kids on the block. Indian J Dermatol Venereol Leprol. 2010;76:602-8.
  • Keystone EC, Genovese MC, Hall S, Miranda PC, Bae SC, Palmer W, Wu Z, Xu S,
  • Hsia EC. Golimumab in patients with active rheumatoid arthritis despite
  • methotrexatetherapy: results through 2 years of the GO-FORWARD study extension. J
  • Rheumatol. 2013;40:1097-103.
  • Inman RD, Davis JC, Heijde DV, Diekman L, Sieper J, Kim SI, Mack M, Han J,
  • Visvanathan S, Xu Z, Hsu B, Beutler A, Braun J. Efficacy and safety of golimumab in
  • patients with ankylosing spondylitis: results of a randomized, double-blind, placebocontrolled,
  • phase III trial. Arthritis Rheum. 2008;58:3402-12.
  • Braun J, Baraliakos X, Hermann KG, Van der Heijde D, Inman RD, Deodhar AA,
  • Baratelle A, Xu S, Xu W, Hsu B. Golimumab reduces spinal inflammation in
  • ankylosing spondylitis: MRI results of the randomised, placebo-controlled GO-RAISE
  • study.Ann Rheum Dis. 2012;71:878-84.
Toplam 103 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Review
Yazarlar

Abdullah Yağız Bu kişi benim

Nilgül Üstün Bu kişi benim

Yayımlanma Tarihi 3 Mart 2015
Gönderilme Tarihi 1 Mart 2015
Yayımlandığı Sayı Yıl 2012 Cilt: 3 Sayı: 12

Kaynak Göster

Vancouver Yağız A, Üstün N. ANKİLOZAN SPONDİLİTTE GÜNCEL TEDAVİ SEÇENEĞİ: TÜMÖR NEKROZ FAKTÖR ALFA ANTAGONİSTLERİ. mkutfd. 2015;3(12):39-47.