ANKİLOZAN SPONDİLİTTE GÜNCEL TEDAVİ SEÇENEĞİ: TÜMÖR NEKROZ FAKTÖR ALFA ANTAGONİSTLERİ

Yıl 2012, Cilt: 3 Sayı: 12, 39 - 47, 03.03.2015

Abdullah Yağız Nilgül Üstün

Öz

Ankilozan spondilit (AS), aksiyal iskelet, entezis bölgeleri ve periferik eklemleri etkileyen kronik, sistemik, inflamatuar bir hastalıktır. AS tedavisinde farmakolojik tedavi yanı sıra eğitim ve fizik tedavi gibi farmakolojik olmayan tedavi metotları da uygulanmaktadır. Farmakolojik ajanlardan tümör nekroz faktör alfa (TNF-α) antagonistleri diğer tedavilere yanıt alınamayan hastalarda kullanılmaktadır. Bunlar infliksimab, etanersept, adalimumab ve golimumabdır. Bu ilaçlar hem klinik hem de laboratuar parametreleri üzerine etkinlik gösterebilmektedirler.
Ancak oluşabilecek yan etkiler nedeniyle dikkatli olunması ve hastaların düzenli takip edilmesi gerekmektedir.

Anahtar Kelimeler

Ankilozan spondilit, güncel tedavi, TNF-α antagonistleri

Current Treatment Option in Ankylosing Spondylitis: Tumor Necrosis Factor Alpha Antagonists

Öz

Ankylosing spondylitis (AS) is a chronic, systemic, inflammatory disease that particularly involves axial skeleton, enthesis regions and peripheral joints. The pharmacological therapy as well as nonpharmacological therapy methods such as patient education and physical therapy are also applied in thetreatment of AS. Tumor necrosis factor alpha (TNF-α) antagonists, the pharmacological agents, are used in patients who fail to respond to other treatments. These are infliximab, etanercept, adalimumab, and golimumab. These drugs can show an efficiency on
both clinical and laboratory parameters. However, the side effects that may occur due caution and patients should be monitored regularly.

Anahtar Kelimeler

Ankylosing spondylitis, current treatment, TNF-α antagonists

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