Yıl 2019, Cilt 10 , Sayı 38, Sayfalar 105 - 107 2019-12-15

Our treatment approach in patients with side effects of L-Carnitine
Oral L-Karnitin Kullanan Hastada Tedavi Yaklaşımımız

Onur KOYUNCU [1] , Senem URFALI [2] , Sibel POLAT [3] , Sedat HAKİMOĞLU [4] , Çağla ÖZBAKIŞ AKKURT [5]


L-Carnitine is an important element of muscle tissue. Because of slimming and developing exercise performance, it has become a populer drug especially for young adults in last 30 years. When used as a medicine, serious adverse effects are emerging in overdoses. In this case report we presented our treatment approach in a patient with developing neurological side effects related to L-Carnitine used in intensive care unit.

L-Karnitinin vücutta, kas dokusunun önemli bir elemanıdır. Zayıflama ve egzersiz performansını arttırıcı etkisinden dolayı özellikle genç erişkinlerde son 30 yılda popüler bir ilaç olmuştur.İlaç olarak kullanıldığında, aşırı dozlarında ciddi istenmeyen etkileri ortaya çıkmaktadır. Biz bu olgu sunumunda, L-Karnitin kullanımına bağlı nörolojik yan etkiler gelişen bir hastada yoğun bakımdaki tedavi yaklaşımımızı sunduk.

  • Stephens FB, Constantin-Teodosiu D, Greenhaff PL. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. J Physiol. 2007;581(2):431–44.
  • Sahlin K. Boosting fat burning with carnitine: an old friend comes out from the shadow. J Physiol. 2011;589(7):1509–1510.
  • Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA & Greenhaff PL. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol 2011; 589, 963–973.
  • Abdali D, Samson SE, Grover AK. How effective are antioxidant supplements in obesity and diabetes. Med Princ Pract 2015;24;201–15.
  • Wang ZY, Liu YY, Liu GH, Lu HB, Mao CY. L-Carnitine and heart disease. Life Sci 2018;194:88-97.
  • Torgutalp Ş., Köse B., Dönmez G. Zayıflama ürünleri gerçekten etkili mi? Turkiye Klinikleri J Sports Med-Special Topics 2016;2(3)
  • Jeukendrup A, Randell R. Fat burners: nutrition supplements that increase fat metabolism. Obes Rev 2011;12:841–51
  • Pooyandjoo M., Nouhi M., Shab-Bidar S., Djafarian K., Olyaeemanesh A. The effect of (L-) carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016;17(10):970-6.
  • Atabilen B.,Yıldıran H. Hemodiyalizde Karnitin.Turk Neph Dial Transpl 2017; 26 (3): 246-253
  • Bloomer R, Farney TM, McAllister M: An Overview of Carnitine. Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. United States of America: Academic Press. 2013; 405-413.
  • Norwegian Scientific Committee for Food Safety (VKM) Risk assessment of “other substances” – L-Carnitine and L-Carnitine-L-tartrate. Opinion of the Panel on Food Additives, Flavourings, Processing Aids, Materials in Contact with Food and Cosmetics of the Norwegian Scientific Committee for Food Safety, 2015.
  • Hathcock, J. N., Shao A. Risk assessment for carnitine. Regul Toxicol Pharmacol. 2006. 46(1): 23-28.
  • Villani RG., Gannon J., Self M., Rich PA.”L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.” Int J Sport Nutr Exerc Metab.2000; 10(2): 199-207.
  • Volek JS., Kraemer WJ., Rubin MR., Gómez AL., Ratamess NA., Gaynor P. L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress. Am J Physiol Endocrinol Metab .2002; 282(2): E474-482.
  • Galloway SD., Craig TP., Cleland SJ. Effects of oral L-carnitine supplementation on insulin sensitivity indices in response to glucose feeding in lean and overweight/obese males. Amino Acids .2011; 41(2): 507-515.
  • Van Oudheusden LJ., Scholte HR .Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids.2002; 67(1): 33-38.
Birincil Dil tr
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Olgu Sunumu
Yazarlar

Orcid: 0000-0002-0364-6638
Yazar: Onur KOYUNCU (Sorumlu Yazar)
Kurum: HATAY MUSTAFA KEMAL ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0003-4500-2408
Yazar: Senem URFALI
Kurum: HATAY MUSTAFA KEMAL ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0001-7426-1877
Yazar: Sibel POLAT
Kurum: HATAY MUSTAFA KEMAL ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0003-0138-0554
Yazar: Sedat HAKİMOĞLU
Kurum: HATAY MUSTAFA KEMAL ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0001-9937-6865
Yazar: Çağla ÖZBAKIŞ AKKURT
Kurum: HATAY MUSTAFA KEMAL ÜNİVERSİTESİ
Ülke: Turkey


Tarihler

Başvuru Tarihi : 11 Ocak 2019
Kabul Tarihi : 24 Mayıs 2019
Yayımlanma Tarihi : 15 Aralık 2019

Vancouver Koyuncu O , Urfalı S , Polat S , Haki̇moğlu S , Özbakış Akkurt Ç . Oral L-Karnitin Kullanan Hastada Tedavi Yaklaşımımız. Mustafa Kemal Üniversitesi Tıp Dergisi. 2019; 105-107.