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The Relationship Between Complete Blood Count Parameters and Mortality in Early Period in Patients Diagnosed as Stroke in Emergency Service

Yıl 2020, Cilt: 11 Sayı: 41, 95 - 102, 01.12.2020
https://doi.org/10.17944/mkutfd.786123

Öz

ABSTRACT
Background: Acute ischemic stroke is the most common cause of death after heart disease and cancer. We aimed to investigate the relationship between parameters of complete blood count in early period of ischemic stroke.
Material Method: The study was organized as a retrospective-archive study. Patients applied Emergency Department and diagnosed as ischemic stroke were included. Demographic findings, complete blood count parameters, imaging tests, duration time in the emergency, hospitalization time were noted.
Results: The mean age of 422 patients was 69.95 ± 12.26 years. Hypertension is the most common additional diseases, with the rate of 68.5%. While the mortality rate is 2.1% in the first 7 days, it was 5.2% in the first 30 days. The mean value of Neutrophil Lymphocyte Ratio (NLR) was significantly higher in patients who died within the first 7 days (p = 0.013). The sensitivity of NLR cut-off value, which was determined as 4.12 for death in the first 7 days, was 77.8% and specificity was 68.5%. Red Cell Distribution Width (RDW) values of patients who died within 30 days were found to be statistically significantly higher when compared to living patients. Advanced age, heart failure and atrial fibrillation were found to be significant risk factors for early mortality.
Conclusion: In conclusion, NLR can be predictive for mortality within the first 7 days and RDW for mortality within the first 30 days. The presence of heart failure and / or atrial fibrillation and the age of 65 and above increase the risk of early mortality.

Keywords: ischemic stroke, red cell distribution width, neutrophil lymphocyte ratio, early mortality

Kaynakça

  • Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; a journal of cerebral circulation. 2013;44(7):2064-89. https://doi.org/10.1161/STR.0b013e318296aeca
  • Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. Journal of Clinical Laboratory Analysis. 2014;28(1):27-31. https://doi.org/10.1002/jcla.21639
  • Kim J, Kim YD, Song TJ, Park JH, Lee HS, Nam CM, et al. Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction. Thrombosis and Haemostasis. 2012;108(2):349-56. https://doi.org/10.1160/TH12-03-0165
  • Li B, Liu X, Cao ZG, Li Y, Liu TM, Wang RT. Elevated mean platelet volume is associated with silent cerebral infarction. Internal Medicine Journal. 2014;44(7):653-7. https://doi.org/10.1111/imj.12454
  • Deb P, Sharma S, Hassan KM. Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology: The Official Journal of The International Society for Pathophysiology / ISP. 2010;17(3):197-218. https://doi.org/10.1016/j.pathophys.2009.12.001
  • Ntaios G, Gurer O, Faouzi M, Aubert C, Michel P. Red cell distribution width does not predict stroke severity or functional outcome. International Journal of Stroke: Official Journal of The International Stroke Society. 2012;7(1):2-6. https://doi.org/10.1111/j.1747-4949.2011.00609.x
  • Yoneda Y, Okuda S, Hamada R, Toyota A, Gotoh J, Watanabe M, et al. Hospital cost of ischemic stroke and intracerebral hemorrhage in Japanese stroke centers. Health Policy. 2005;73(2):202-11. https://doi.org/10.1016/j.healthpol.2004.11.016
  • Reganon E, Vila V, Martinez-Sales V, Vaya A, Lago A, Alonso P, et al. Association between inflammation and hemostatic markers in atherothrombotic stroke. Thrombosis Research. 2003;112(4):217-21. https://doi.org/10.1016/j.thromres.2003.12.008
  • Arrich J, Mullner M, Lalouschek W, Greisenegger S, Crevenna R, Herkner H. Influence of socioeconomic status and gender on stroke treatment and diagnostics. Stroke; A Journal of Cerebral Circulation. 2008;39(7):2066-72. https://doi.org/10.1161/STROKEAHA.107.506147
  • Demirci S, Yalcıner BZ, Bakac G, Dayan C, Aysal F, Baybas S. İnmelerde tekrarlayıcılığı etkileyen risk faktörleri. Düşünen Adam Psikiyatri ve Nöroloji Bilimleri Dergisi. 2010;23:38-43. https://doi.org/10.5350/DAJPN2010230106
  • Bogousslavsky J, Van Melle G, Regli F. The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke. Stroke; A Journal of Cerebral Circulation. 1988;19(9):1083-92. https://doi.org/10.1161/01.STR.19.9.1083
  • Kumral E, Ozkaya B, Sagduyu A, Sirin H, Vardarli E, Pehlivan M. The Ege Stroke Registry: a hospital-based study in the Aegean region, Izmir, Turkey. Analysis of 2,000 stroke patients. Cerebrovascular Diseases. 1998;8(5):278-88. https://doi.org/10.1159/000015866
  • Demir CF, Berilgen MS, Bulut S, Aydın Ülger M, S. Ö. Yukarı Fırat Bölümünde Genç İskemik İnme Olguları. . Turkiye Klinikleri J Med Sci. 2007;27:791-6.
  • Polovina M, Potpara T, Giga V, Stepanovic J, Ostojic M. Impaired endothelial function in lone atrial fibrillation. Vojnosanitetski Pregled. 2013;70(10):908-14. https://doi.org/10.2298/VSP110429016P
  • Lewington S, Clarke R, Qizilbash N, Peto R, Collins R, Prospective Studies C. Age specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360(9349):1903-13. https://doi.org/10.1016/S0140-6736(02)11911-8
  • Liu LS, Caguioa ES, Park CG, Quek DK, Saito I, Venketasubramanian N, et al. Reducing stroke risk in hypertensive patients: Asian Consensus Conference recommendations. International Journal of Stroke: Official Journal of The International Stroke Society. 2006;1(3):150-7. https://doi.org/10.1111/j.1747-4949.2006.00041.x
  • Somay G, Topaloğlu G, H. S. Cerebrovascular Risk Factors and Stroke Subtypes in Different Age Groups: A Hospital-Based Study. . Turk J Med Sci. 2006;36:23-9.
  • Bornstein NM, Aronovich BD, Karepov VG, Gur AY, Treves TA, Oved M, et al. The Tel Aviv Stroke Registry. 3600 consecutive patients. Stroke; A Journal of Cerebral Circulation. 1996;27(10):1770-3. https://doi.org/10.1161/01.STR.27.10.1770
  • Arevalo-Lorido JC, Carretero-Gomez J, Alvarez-Oliva A, Gutierrez-Montano C, Fernandez-Recio JM, Najarro-Diez F. Mean platelet volume in acute phase of ischemic stroke, as predictor of mortality and functional outcome after 1 year. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association. 2013;22(4):297-303. https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.09.009
  • Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Archives of Internal Medicine. 2009;169(6):588-94. https://doi.org/10.1001/archinternmed.2009.55
  • England JM, Down MC. Red-cell-volume distribution curves and the measurement of anisocytosis. Lancet. 1974;1(7860):701-3. https://doi.org/10.1016/S0140-6736(74)92904-3
  • Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M, et al. Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People with Coronary Disease. Circulation. 2008;117(2):163-8. https://doi.org/10.1161/CIRCULATIONAHA.107.727545
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. Journal of The Neurological Sciences. 2009;277(1-2):103-8. https://doi.org/10.1016/j.jns.2008.10.024
  • Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massaro JM, et al. Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke; A Journal of Cerebral Circulation. 2001;32(11):2575-9. https://doi.org/10.1161/hs1101.098151
  • Ku NS, Kim HW, Oh HJ, Kim YC, Kim MH, Song JE, et al. Red blood cell distribution width is an independent predictor of mortality in patients with gram negative bacteremia. Shock. 2012;38(2):123-7. https://doi.org/10.1097/SHK.0b013e31825e2a85
  • Ghaffari S. Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxidants & redox signaling. 2008;10(11):1923-40. https://doi.org/10.1089/ars.2008.2142
  • Kara H, Degirmenci S, Bayir A, Ak A, Akinci M, Dogru A, et al. Red cell distribution width and neurological scoring systems in acute stroke patients. Neuropsychiatric disease and treatment. 2015;11:733-9. https://doi.org/10.2147/NDT.S81525
  • Ramirez-Moreno JM, Gonzalez-Gomez M, Ollero-Ortiz A, Roa-Montero AM, Gomez-Baquero MJ, Constantino-Silva AB. Relation between red blood cell distribution width and ischemic stroke: a case-control study. International Journal of Stroke: Official Journal of The International Stroke Society. 2013;8(6):E36. https://doi.org/10.1111/ijs.12091
  • Soderholm M, Borne Y, Hedblad B, Persson M, Engstrom G. Red cell distribution width in relation to incidence of stroke and carotid atherosclerosis: a population-based cohort study. PloS One. 2015;10(5):e0124957. https://doi.org/10.1371/journal.pone.0124957
  • Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Archives of Internal Medicine. 2009;169(5):515-23. https://doi.org/10.1001/archinternmed.2009.11
  • Mayda-Domac F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. Journal of Stroke and Cerebrovascular Diseases. 2010;19(1):66-72. https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.03.003
  • Kishk YT, Trowbridge EA, Martin JF. Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site. Clinical Science. 1985;68(4):419-25. https://doi.org/10.1042/cs0680419
  • O'Malley T, Langhorne P, Elton RA, Stewart C. Platelet size in stroke patients. Stroke. 1995;26(6):995-9. https://doi.org/10.1161/01.STR.26.6.995
  • Arikanoglu A, Yucel Y, Acar A, Cevik MU, Akil E, Varol S. The relationship of the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients. European Review for Medical and Pharmacological Sciences. 2013;17(13):1774-7.
  • Tamer D, Fevzi Y, Deniz AE, Cemil K, Fatih B, Cihat Y, et al. The value of serum mean platelet volume in ischaemic stroke patient. JPMA The Journal of the Pakistan Medical Association. 2013;63(12):1509-10.
  • Cho SY, Jeon YL, Choi SK, Suh JT, Lee HJ, Park TS. Mean platelet volume in Korean patients with acute ischemic stroke: a gender difference. Platelets. 2013;24(1):75-6. https://doi.org/10.3109/09537104.2012.658109
  • Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;31(5):1215-8. https://doi.org/10.1161/ATVBAHA.110.221788
  • Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets. 1998;9(6):359-64. https://doi.org/10.1080/09537109876429
  • Pikija S, Cvetko D, Hajduk M, Trkulja V. Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome. Clinical Neurology and Neurosurgery. 2009;111(7):568-73. https://doi.org/10.1016/j.clineuro.2009.04.002
  • Zhao L, Dai Q, Chen X, Li S, Shi R, Yu S, et al. Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in Patients with Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases. 2016;25(4):739-44. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.012
  • Buck BH, Liebeskind DS, Saver JL, Bang OY, Yun SW, Starkman S, et al. Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke; a Journal of Cerebral Circulation. 2008;39(2):355-60. https://doi.org/10.1161/STROKEAHA.107.490128
  • Kim J, Song TJ, Park JH, Lee HS, Nam CM, Nam HS, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis. 2012;222(2):464-7. https://doi.org/10.1016/j.atherosclerosis.2012.02.042
  • Gokhan S, Ozhasenekler A, Mansur Durgun H, Akil E, Ustundag M, Orak M. Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack. European Review for Medical and Pharmacological Sciences. 2013;17(5):653-7.
  • Tokgoz S, Keskin S, Kayrak M, Seyithanoglu A, Ogmegul A. Is neutrophil/lymphocyte ratio predict to short-term mortality in acute cerebral infarct independently from infarct volume? Journal of Stroke and Cerebrovascular Diseases. 2014;23(8):2163-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.007
  • Belen E, Sungur A, Sungur MA, Erdogan G. Increased Neutrophil to Lymphocyte Ratio in Patients With Resistant Hypertension. Journal of Clinical Hypertension. 2015;17(7):532-7. https://doi.org/10.1111/jch.12533
  • Huang YC, Hu CJ, Lee TH, Yang JT, Weng HH, Lin LC, et al. The impact factors on the cost and length of stay among acute ischemic stroke. Journal of Stroke and Cerebrovascular Diseases. 2013;22(7):e152-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.10.014
  • Jain M, Damania D, Jain AR, Kanthala AR, Ganti L, Jahromi BS. Does prolonged length of stay in the emergency department affect outcome for stroke patients? The Western Journal of Emergency Medicine. 2014;15(3):267-75. https://doi.org/10.5811/westjem.2013.8.16186
  • Kıyan S, Özsaraç M, Ersel M, Aksay E, Yürüktümen A, Musalar E, et al. Retrospective Analysis of 124 Acute Ischemic Stroke Patients Who Attended To The Emergency Department In One Year Period. JAEM 2009;8:3.
  • Akhtar N, Kamran S, Singh R, Cameron P, Bourke P, Khan R, et al. Prolonged Stay of Stroke Patients in the Emergency Department May Lead to an Increased Risk of Complications, Poor Recovery, and Increased Mortality. Journal of Stroke and Cerebrovascular Diseases. 2016;25(3):672-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.10.018
  • Nakibuuka J, Sajatovic M, Nankabirwa J, Ssendikadiwa C, Furlan AJ, Katabira E, et al. Early mortality and functional outcome after acute stroke in Uganda: prospective study with 30 day follow-up. SpringerPlus. 2015;4:450. https://doi.org/10.1186/s40064-015-1252-8
  • Ganesh A, Lindsay P, Fang J, Kapral MK, Cote R, Joiner I, et al. Integrated systems of stroke care and reduction in 30-day mortality: A retrospective analysis. Neurology. 2016;8:86(10):898-904. https://doi.org/10.1212/WNL.0000000000002443

Acil Serviste İnme Tanısı Alan Hastalarda Tam Kan Sayımı Parametreleri ve Erken Dönem Mortalite İlişkisi

Yıl 2020, Cilt: 11 Sayı: 41, 95 - 102, 01.12.2020
https://doi.org/10.17944/mkutfd.786123

Öz

ABSTRACT
Background: Acute ischemic stroke is the most common cause of death after heart disease and cancer. We aimed to investigate the relationship between parameters of complete blood count in early period of ischemic stroke.
Material Method: The study was organized as a retrospective-archive study. Patients applied Emergency Department and diagnosed as ischemic stroke were included. Demographic findings, complete blood count parameters, imaging tests, duration time in the emergency, hospitalization time were noted.
Results: The mean age of 422 patients was 69.95 ± 12.26 years. Hypertension is the most common additional diseases, with the rate of 68.5%. While the mortality rate is 2.1% in the first 7 days, it was 5.2% in the first 30 days. The mean value of Neutrophil Lymphocyte Ratio (NLR) was significantly higher in patients who died within the first 7 days (p = 0.013). The sensitivity of NLR cut-off value, which was determined as 4.12 for death in the first 7 days, was 77.8% and specificity was 68.5%. Red Cell Distribution Width (RDW) values of patients who died within 30 days were found to be statistically significantly higher when compared to living patients. Advanced age, heart failure and atrial fibrillation were found to be significant risk factors for early mortality.
Conclusion: In conclusion, NLR can be predictive for mortality within the first 7 days and RDW for mortality within the first 30 days. The presence of heart failure and / or atrial fibrillation and the age of 65 and above increase the risk of early mortality.

Keywords: ischemic stroke, red cell distribution width, neutrophil lymphocyte ratio, early mortality

Kaynakça

  • Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; a journal of cerebral circulation. 2013;44(7):2064-89. https://doi.org/10.1161/STR.0b013e318296aeca
  • Celikbilek A, Ismailogullari S, Zararsiz G. Neutrophil to lymphocyte ratio predicts poor prognosis in ischemic cerebrovascular disease. Journal of Clinical Laboratory Analysis. 2014;28(1):27-31. https://doi.org/10.1002/jcla.21639
  • Kim J, Kim YD, Song TJ, Park JH, Lee HS, Nam CM, et al. Red blood cell distribution width is associated with poor clinical outcome in acute cerebral infarction. Thrombosis and Haemostasis. 2012;108(2):349-56. https://doi.org/10.1160/TH12-03-0165
  • Li B, Liu X, Cao ZG, Li Y, Liu TM, Wang RT. Elevated mean platelet volume is associated with silent cerebral infarction. Internal Medicine Journal. 2014;44(7):653-7. https://doi.org/10.1111/imj.12454
  • Deb P, Sharma S, Hassan KM. Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology: The Official Journal of The International Society for Pathophysiology / ISP. 2010;17(3):197-218. https://doi.org/10.1016/j.pathophys.2009.12.001
  • Ntaios G, Gurer O, Faouzi M, Aubert C, Michel P. Red cell distribution width does not predict stroke severity or functional outcome. International Journal of Stroke: Official Journal of The International Stroke Society. 2012;7(1):2-6. https://doi.org/10.1111/j.1747-4949.2011.00609.x
  • Yoneda Y, Okuda S, Hamada R, Toyota A, Gotoh J, Watanabe M, et al. Hospital cost of ischemic stroke and intracerebral hemorrhage in Japanese stroke centers. Health Policy. 2005;73(2):202-11. https://doi.org/10.1016/j.healthpol.2004.11.016
  • Reganon E, Vila V, Martinez-Sales V, Vaya A, Lago A, Alonso P, et al. Association between inflammation and hemostatic markers in atherothrombotic stroke. Thrombosis Research. 2003;112(4):217-21. https://doi.org/10.1016/j.thromres.2003.12.008
  • Arrich J, Mullner M, Lalouschek W, Greisenegger S, Crevenna R, Herkner H. Influence of socioeconomic status and gender on stroke treatment and diagnostics. Stroke; A Journal of Cerebral Circulation. 2008;39(7):2066-72. https://doi.org/10.1161/STROKEAHA.107.506147
  • Demirci S, Yalcıner BZ, Bakac G, Dayan C, Aysal F, Baybas S. İnmelerde tekrarlayıcılığı etkileyen risk faktörleri. Düşünen Adam Psikiyatri ve Nöroloji Bilimleri Dergisi. 2010;23:38-43. https://doi.org/10.5350/DAJPN2010230106
  • Bogousslavsky J, Van Melle G, Regli F. The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke. Stroke; A Journal of Cerebral Circulation. 1988;19(9):1083-92. https://doi.org/10.1161/01.STR.19.9.1083
  • Kumral E, Ozkaya B, Sagduyu A, Sirin H, Vardarli E, Pehlivan M. The Ege Stroke Registry: a hospital-based study in the Aegean region, Izmir, Turkey. Analysis of 2,000 stroke patients. Cerebrovascular Diseases. 1998;8(5):278-88. https://doi.org/10.1159/000015866
  • Demir CF, Berilgen MS, Bulut S, Aydın Ülger M, S. Ö. Yukarı Fırat Bölümünde Genç İskemik İnme Olguları. . Turkiye Klinikleri J Med Sci. 2007;27:791-6.
  • Polovina M, Potpara T, Giga V, Stepanovic J, Ostojic M. Impaired endothelial function in lone atrial fibrillation. Vojnosanitetski Pregled. 2013;70(10):908-14. https://doi.org/10.2298/VSP110429016P
  • Lewington S, Clarke R, Qizilbash N, Peto R, Collins R, Prospective Studies C. Age specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360(9349):1903-13. https://doi.org/10.1016/S0140-6736(02)11911-8
  • Liu LS, Caguioa ES, Park CG, Quek DK, Saito I, Venketasubramanian N, et al. Reducing stroke risk in hypertensive patients: Asian Consensus Conference recommendations. International Journal of Stroke: Official Journal of The International Stroke Society. 2006;1(3):150-7. https://doi.org/10.1111/j.1747-4949.2006.00041.x
  • Somay G, Topaloğlu G, H. S. Cerebrovascular Risk Factors and Stroke Subtypes in Different Age Groups: A Hospital-Based Study. . Turk J Med Sci. 2006;36:23-9.
  • Bornstein NM, Aronovich BD, Karepov VG, Gur AY, Treves TA, Oved M, et al. The Tel Aviv Stroke Registry. 3600 consecutive patients. Stroke; A Journal of Cerebral Circulation. 1996;27(10):1770-3. https://doi.org/10.1161/01.STR.27.10.1770
  • Arevalo-Lorido JC, Carretero-Gomez J, Alvarez-Oliva A, Gutierrez-Montano C, Fernandez-Recio JM, Najarro-Diez F. Mean platelet volume in acute phase of ischemic stroke, as predictor of mortality and functional outcome after 1 year. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association. 2013;22(4):297-303. https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.09.009
  • Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Archives of Internal Medicine. 2009;169(6):588-94. https://doi.org/10.1001/archinternmed.2009.55
  • England JM, Down MC. Red-cell-volume distribution curves and the measurement of anisocytosis. Lancet. 1974;1(7860):701-3. https://doi.org/10.1016/S0140-6736(74)92904-3
  • Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M, et al. Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People with Coronary Disease. Circulation. 2008;117(2):163-8. https://doi.org/10.1161/CIRCULATIONAHA.107.727545
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. Journal of The Neurological Sciences. 2009;277(1-2):103-8. https://doi.org/10.1016/j.jns.2008.10.024
  • Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massaro JM, et al. Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke; A Journal of Cerebral Circulation. 2001;32(11):2575-9. https://doi.org/10.1161/hs1101.098151
  • Ku NS, Kim HW, Oh HJ, Kim YC, Kim MH, Song JE, et al. Red blood cell distribution width is an independent predictor of mortality in patients with gram negative bacteremia. Shock. 2012;38(2):123-7. https://doi.org/10.1097/SHK.0b013e31825e2a85
  • Ghaffari S. Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxidants & redox signaling. 2008;10(11):1923-40. https://doi.org/10.1089/ars.2008.2142
  • Kara H, Degirmenci S, Bayir A, Ak A, Akinci M, Dogru A, et al. Red cell distribution width and neurological scoring systems in acute stroke patients. Neuropsychiatric disease and treatment. 2015;11:733-9. https://doi.org/10.2147/NDT.S81525
  • Ramirez-Moreno JM, Gonzalez-Gomez M, Ollero-Ortiz A, Roa-Montero AM, Gomez-Baquero MJ, Constantino-Silva AB. Relation between red blood cell distribution width and ischemic stroke: a case-control study. International Journal of Stroke: Official Journal of The International Stroke Society. 2013;8(6):E36. https://doi.org/10.1111/ijs.12091
  • Soderholm M, Borne Y, Hedblad B, Persson M, Engstrom G. Red cell distribution width in relation to incidence of stroke and carotid atherosclerosis: a population-based cohort study. PloS One. 2015;10(5):e0124957. https://doi.org/10.1371/journal.pone.0124957
  • Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Archives of Internal Medicine. 2009;169(5):515-23. https://doi.org/10.1001/archinternmed.2009.11
  • Mayda-Domac F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. Journal of Stroke and Cerebrovascular Diseases. 2010;19(1):66-72. https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.03.003
  • Kishk YT, Trowbridge EA, Martin JF. Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site. Clinical Science. 1985;68(4):419-25. https://doi.org/10.1042/cs0680419
  • O'Malley T, Langhorne P, Elton RA, Stewart C. Platelet size in stroke patients. Stroke. 1995;26(6):995-9. https://doi.org/10.1161/01.STR.26.6.995
  • Arikanoglu A, Yucel Y, Acar A, Cevik MU, Akil E, Varol S. The relationship of the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients. European Review for Medical and Pharmacological Sciences. 2013;17(13):1774-7.
  • Tamer D, Fevzi Y, Deniz AE, Cemil K, Fatih B, Cihat Y, et al. The value of serum mean platelet volume in ischaemic stroke patient. JPMA The Journal of the Pakistan Medical Association. 2013;63(12):1509-10.
  • Cho SY, Jeon YL, Choi SK, Suh JT, Lee HJ, Park TS. Mean platelet volume in Korean patients with acute ischemic stroke: a gender difference. Platelets. 2013;24(1):75-6. https://doi.org/10.3109/09537104.2012.658109
  • Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, Wagner OF, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;31(5):1215-8. https://doi.org/10.1161/ATVBAHA.110.221788
  • Butterworth RJ, Bath PM. The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets. 1998;9(6):359-64. https://doi.org/10.1080/09537109876429
  • Pikija S, Cvetko D, Hajduk M, Trkulja V. Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome. Clinical Neurology and Neurosurgery. 2009;111(7):568-73. https://doi.org/10.1016/j.clineuro.2009.04.002
  • Zhao L, Dai Q, Chen X, Li S, Shi R, Yu S, et al. Neutrophil-to-Lymphocyte Ratio Predicts Length of Stay and Acute Hospital Cost in Patients with Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases. 2016;25(4):739-44. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.11.012
  • Buck BH, Liebeskind DS, Saver JL, Bang OY, Yun SW, Starkman S, et al. Early neutrophilia is associated with volume of ischemic tissue in acute stroke. Stroke; a Journal of Cerebral Circulation. 2008;39(2):355-60. https://doi.org/10.1161/STROKEAHA.107.490128
  • Kim J, Song TJ, Park JH, Lee HS, Nam CM, Nam HS, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis. 2012;222(2):464-7. https://doi.org/10.1016/j.atherosclerosis.2012.02.042
  • Gokhan S, Ozhasenekler A, Mansur Durgun H, Akil E, Ustundag M, Orak M. Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack. European Review for Medical and Pharmacological Sciences. 2013;17(5):653-7.
  • Tokgoz S, Keskin S, Kayrak M, Seyithanoglu A, Ogmegul A. Is neutrophil/lymphocyte ratio predict to short-term mortality in acute cerebral infarct independently from infarct volume? Journal of Stroke and Cerebrovascular Diseases. 2014;23(8):2163-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.007
  • Belen E, Sungur A, Sungur MA, Erdogan G. Increased Neutrophil to Lymphocyte Ratio in Patients With Resistant Hypertension. Journal of Clinical Hypertension. 2015;17(7):532-7. https://doi.org/10.1111/jch.12533
  • Huang YC, Hu CJ, Lee TH, Yang JT, Weng HH, Lin LC, et al. The impact factors on the cost and length of stay among acute ischemic stroke. Journal of Stroke and Cerebrovascular Diseases. 2013;22(7):e152-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.10.014
  • Jain M, Damania D, Jain AR, Kanthala AR, Ganti L, Jahromi BS. Does prolonged length of stay in the emergency department affect outcome for stroke patients? The Western Journal of Emergency Medicine. 2014;15(3):267-75. https://doi.org/10.5811/westjem.2013.8.16186
  • Kıyan S, Özsaraç M, Ersel M, Aksay E, Yürüktümen A, Musalar E, et al. Retrospective Analysis of 124 Acute Ischemic Stroke Patients Who Attended To The Emergency Department In One Year Period. JAEM 2009;8:3.
  • Akhtar N, Kamran S, Singh R, Cameron P, Bourke P, Khan R, et al. Prolonged Stay of Stroke Patients in the Emergency Department May Lead to an Increased Risk of Complications, Poor Recovery, and Increased Mortality. Journal of Stroke and Cerebrovascular Diseases. 2016;25(3):672-8. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.10.018
  • Nakibuuka J, Sajatovic M, Nankabirwa J, Ssendikadiwa C, Furlan AJ, Katabira E, et al. Early mortality and functional outcome after acute stroke in Uganda: prospective study with 30 day follow-up. SpringerPlus. 2015;4:450. https://doi.org/10.1186/s40064-015-1252-8
  • Ganesh A, Lindsay P, Fang J, Kapral MK, Cote R, Joiner I, et al. Integrated systems of stroke care and reduction in 30-day mortality: A retrospective analysis. Neurology. 2016;8:86(10):898-904. https://doi.org/10.1212/WNL.0000000000002443
Toplam 51 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Original Articles
Yazarlar

Hüseyin Avni Demir 0000-0003-2891-9345

Fikret Bildik Bu kişi benim 0000-0003-2464-0232

Tülin Gesoğlu Bu kişi benim 0000-0002-9341-5525

Dikmen Çalışkan Bu kişi benim 0000-0002-9015-5983

Reyhan Şahnaoğlu Bu kişi benim 0000-0002-7429-7033

Ekim Gökçe Bu kişi benim 0000-0001-5742-7601

Yayımlanma Tarihi 1 Aralık 2020
Gönderilme Tarihi 26 Ağustos 2020
Kabul Tarihi 24 Ekim 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 11 Sayı: 41

Kaynak Göster

Vancouver Demir HA, Bildik F, Gesoğlu T, Çalışkan D, Şahnaoğlu R, Gökçe E. The Relationship Between Complete Blood Count Parameters and Mortality in Early Period in Patients Diagnosed as Stroke in Emergency Service. mkutfd. 2020;11(41):95-102.