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Relationship Between Diabetic Peripheral Neuropathy and Vitamin D

Yıl 2021, Cilt: 12 Sayı: 43, 100 - 105, 19.08.2021
https://doi.org/10.17944/mkutfd.944560

Öz

Objective: We aimed to compare electrophysiologically supported and unsupported diabetic peripheral neuropathy (DPN) patients in terms of vitamin D levels within themselves and with the control group.Methods: Patients who applied to Hatay State Hospital Physical Medicine and Rehabilitation Outpatient Clinic and were diagnosed with DPN were divided into two groups according to whether or not pathological findings were detected electrophysiologically. Patients of similar age and gender, who applied to the outpatient clinic with complaints of muscle pain, formed the control group and the groups were compared in terms of vitamin D levels. DPN subgroups were also compared in terms of HbA1c levels and duration of diabetes.Results: No statistically significant difference was found between the DPN groups and the control group in terms of age and gender. Vitamin D levels were found to be significantly higher in the control group compared to the electrophysiologically supported DPN group. When DPN subgroups were compared within themselves, diabetes duration and HbA1c levels were found to be statistically significantly higher in the electrophysiologically supported DPN group.Conclusion: Low vitamin D levels can accelerate the development of neuropathy in diabetic patients and worsen the clinical picture of patients.

Kaynakça

  • Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol, 2012. 11(6): p. 521-34. https://doi.org/10.1016/S1474-4422(12)70065-0
  • Sari A, Akdoğan AZ, Arifoglu KC, Bilir KB, Durmus B. Does Vitamin D Affect Diabetic Neuropathic Pain and Balance? J Pain Res, 2020. 13: p. 171-179. https://doi.org/10.2147/JPR.S203176
  • Edwards JL, Vincent AM, Cheng HT, Feldman EL. Diabetic neuropathy: mechanisms to management. Pharmacol Ther, 2008. 120(1): p. 1-34. https://doi.org/10.1016/j.pharmthera.2008.05.005
  • Tahrani AA, Ball A, Shepherd L, Rahim A, Jones AF, Bates A. The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK. Int J Clin Pract, 2010. 64(3): p. 351-5. https://doi.org/10.1111/j.1742-1241.2009.02221.x
  • Usluogullari CA, Balkan F, Caner S, Ucler R, Kaya C, Ersoy R, et al. The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus. BMC Endocr Disord, 2015. 15(33): p. 015-0029. https://doi.org/10.1186/s12902-015-0029-y
  • Skalli S, Muller M, Pradines S, Halimi S, Wion-Barbot N. Vitamin D deficiency and peripheral diabetic neuropathy: Eur J Intern Med. 2012 Mar;23(2):e67-8. Epub 2011 Dec 10. https://doi.org/10.1016/j.ejim.2011.11.008
  • Lee JI, Oh SJ, Ha WC, Kwon HS, Sohn TS, Son HS, et al. Serum 25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes. Diabetes Res Clin Pract, 2012. 95(1): p. 42-7. https://doi.org/10.1016/j.diabres.2011.09.006
  • Suzuki A, Kotake M, Ono Y, Kato T, Oda N, Hayakawa N, et al. Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocr J, 2006. 53(4): p. 503-10. https://doi.org/10.1507/endocrj.K06-001
  • Al-Timimi, D.J. and A.F. Ali, Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control. J Clin Diagn Res, 2013. 7(12): p. 2686-8. https://doi.org/10.7860/JCDR/2013/6712.3733
  • Olt, S. Relationship between vitamin D and glycemic control in patients with type 2 diabetes mellitus. Int J Clin Exp Med, 2015. 8(10): p. 19180-3.
  • Taniura H, Ito M, Sanada N, Kuramoto N, Ohno Y, Nakamichi N, et al. Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J Neurosci Res, 2006. 83(7): p. 1179-89. https://doi.org/10.1002/jnr.20824
  • Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, et al. Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury. PLOS ONE, 2013. 8(5). https://doi.org/10.1371/journal.pone.0065034
  • Chabas JF, Alluin O, Rao G, Garcia S, Lavaut MN, Risso JJ, et al. Vitamin D2 potentiates axon regeneration. J Neurotrauma, 2008. 25(10): p. 1247-56. https://doi.org/10.1089/neu.2008.0593
  • Shehab D, Al-Jarallah K, Abdella N, Mojiminiyi OA, Al Mohamedy H. Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus. Med Princ Pract, 2015. 24(3): p. 250-6. https://doi.org/10.1159/000375304
  • Pinelli NR, Jaber LA, Brown MB, Herman WH. Serum 25-hydroxy vitamin d and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans. Diabetes Care, 2010. 33(6): p. 1373-5. https://doi.org/10.2337/dc09-2199
  • Alam U, Nelson AJ, Cuthbertson DJ, Malik RA. An update on vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy: a narrative review. Future Neurology, 2018. 13(3): p. 135-142. https://doi.org/10.2217/fnl-2017-0034
  • Putz Z, Martos T, Németh N, Körei AE, Vági OE, Kempler MS, et al. Is there an association between diabetic neuropathy and low vitamin D levels? Curr Diab Rep, 2014. 14(10): p. 014-0537. https://doi.org/10.1007/s11892-014-0537-6
  • Timar B, Timar R, Gaiță L, Oancea C, Levai C, Lungeanu D. The Impact of Diabetic Neuropathy on Balance and on the Risk of Falls in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study. PLOS ONE, 2016. 11(4). https://doi.org/10.1371/journal.pone.0154654
  • Muir, S.W. and M. Montero-Odasso, Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc, 2011. 59(12): p. 2291-300. https://doi.org/10.1111/j.1532-5415.2011.03733.x
  • Akdeniz S, Hepguler S, Öztürk C, Atamaz FC. The relation between vitamin D and postural balance according to clinical tests and tetrax posturography. J Phys Ther Sci, 2016. 28(4): p. 1272-7. https://doi.org/10.1589/jpts.28.1272
  • Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA. Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes? Diabet Med, 2012. 29(1): p. 43-9. https://doi.org/10.1111/j.1464-5491.2011.03510.x
  • Alamdari A, Mozafari R, Tafakhori A, Faghihi-Kashani S, Hafezi-Nejad N, Sheikhbahaei S, et al. An inverse association between serum vitamin D levels with the presence and severity of impaired nerve conduction velocity and large fiber peripheral neuropathy in diabetic subjects. Neurol Sci, 2015. 36(7): p. 1121-6. https://doi.org/10.1007/s10072-015-2207-0
  • Celikbilek A, Gocmen AY, Tanik N, Borekci E, Adam M, Celikbilek M, et al. Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey. Acta Neurol Belg, 2015. 115(1): p. 47-52. https://doi.org/10.1007/s13760-014-0304-0
  • Shillo P, Selvarajah D, Greig M, Gandhi R, Rao G, Wilkinson ID, et al. Reduced vitamin D levels in painful diabetic peripheral neuropathy. Diabet Med, 2019. 36(1): p. 44-51. https://doi.org/10.1111/dme.13798
  • Bell, D.S., Reversal of the Symptoms of Diabetic Neuropathy through Correction of Vitamin D Deficiency in a Type 1 Diabetic Patient. Case Rep Endocrinol, 2012. 165056(10): p. 12. https://doi.org/10.1155/2012/165056
  • Dalgård C, Petersen MS, Weihe P, Grandjean P. Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. Diabetes Care, 2011. 34(6): p. 1284-8. https://doi.org/10.2337/dc10-2084
  • Basit A, Basit KA, Fawwad A, Shaheen F, Fatima N, Petropoulos IN, et al. Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Research and Care, 2016. 4(1): p. e000148. https://doi.org/10.1136/bmjdrc-2015-000148
  • Anand P, Terenghi G, Warner G, Kopelman P, Williams-Chestnut RE, Sinicropi DV. The role of endogenous nerve growth factor in human diabetic neuropathy. Nat Med, 1996. 2(6): p. 703-7. https://doi.org/10.1038/nm0696-703
  • Ozuguz U, Oruc S, Ulu MS, Demirbas H, Acay A, Coker B, et al. Does vitamin D have any role in the improvement of diabetic peripheral neuropathy in type 1 diabetic patients? J Endocrinol Invest, 2016. 39(12): p. 1411-1417. https://doi.org/10.1007/s40618-016-0509-6
  • Pinzon, R.T., A. Tjung, and A.W. Pradana, Is there any relations hip between vitamin d levels and the severity of diabetic peripheral neuropathy? Romanian Journal of Neurology, 2020. 19(2). https://doi.org/10.37897/RJN.2020.2.6
  • Soderstrom LH, Johnson SP, Diaz VA, Mainous AG, 3rd. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES. Diabet Med, 2012. 29(1): p. 50-5. https://doi.org/10.1111/j.1464-5491.2011.03379.x
  • Bilir B, Tulubas F, Bilir BE, Atile NS, Kara SP, Yildirim T, et al. The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy. J Phys Ther Sci, 2016. 28(7): p. 2159-63. https://doi.org/10.1589/jpts.28.2159

Diyabetik Periferik Nöropati ve Vitamin D İlişkisi

Yıl 2021, Cilt: 12 Sayı: 43, 100 - 105, 19.08.2021
https://doi.org/10.17944/mkutfd.944560

Öz

Amaç: Elektrofizyolojik olarak desteklenen ve desteklenmeyen diyabetik periferik nöropati (DPN) hastalarının, kendi içerisinde ve kontrol grubu ile D vitamini düzeyleri açısından karşılaştırması amaçlanmıştır.Yöntem: Hatay Devlet Hastanesi Fiziksel Tıp ve Rehabilitasyon Polikliniğine başvurmuş ve DPN tanısı almış hastalar elektrofizyolojik olarak patolojik bulgu saptanıp, saptanmamalarına göre iki gruba ayrıldı. Benzer yaş ve cinsiyette, kas ağrısı şikâyeti ile poliklinik başvurusu olan hastalar da kontrol grubunu oluşturdu ve gruplar D vitamini düzeyleri açısından karşılaştırıldı. DPN alt grupları da kendi içerisinde HbA1c seviyeleri ve diyabet süreleri açısından kıyaslandı.Bulgular: DPN grupları ve kontrol grubu arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı farklılık saptanmadı. Vitamin D düzeyleri, elektrofizyolojik olarak desteklenen DPN grubuna kıyasla, kontrol grubunda anlamlı derecede daha yüksek bulunmuştur. DPN alt grupları kendi içerisinde karşılaştırıldığında elektrofizyolojik olarak desteklenen DPN grubunda, diyabet süresi ve HbA1c düzeyleri istatistiksel olarak anlamlı olacak şekilde daha yüksek bulunmuştur.Sonuç: Düşük D vitamini seviyeleri diyabetik hastalarda nöropati gelişimini hızlandırabilir ve hastaların klinik durumlarını kötüleştirebilir.

Kaynakça

  • Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol, 2012. 11(6): p. 521-34. https://doi.org/10.1016/S1474-4422(12)70065-0
  • Sari A, Akdoğan AZ, Arifoglu KC, Bilir KB, Durmus B. Does Vitamin D Affect Diabetic Neuropathic Pain and Balance? J Pain Res, 2020. 13: p. 171-179. https://doi.org/10.2147/JPR.S203176
  • Edwards JL, Vincent AM, Cheng HT, Feldman EL. Diabetic neuropathy: mechanisms to management. Pharmacol Ther, 2008. 120(1): p. 1-34. https://doi.org/10.1016/j.pharmthera.2008.05.005
  • Tahrani AA, Ball A, Shepherd L, Rahim A, Jones AF, Bates A. The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK. Int J Clin Pract, 2010. 64(3): p. 351-5. https://doi.org/10.1111/j.1742-1241.2009.02221.x
  • Usluogullari CA, Balkan F, Caner S, Ucler R, Kaya C, Ersoy R, et al. The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus. BMC Endocr Disord, 2015. 15(33): p. 015-0029. https://doi.org/10.1186/s12902-015-0029-y
  • Skalli S, Muller M, Pradines S, Halimi S, Wion-Barbot N. Vitamin D deficiency and peripheral diabetic neuropathy: Eur J Intern Med. 2012 Mar;23(2):e67-8. Epub 2011 Dec 10. https://doi.org/10.1016/j.ejim.2011.11.008
  • Lee JI, Oh SJ, Ha WC, Kwon HS, Sohn TS, Son HS, et al. Serum 25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes. Diabetes Res Clin Pract, 2012. 95(1): p. 42-7. https://doi.org/10.1016/j.diabres.2011.09.006
  • Suzuki A, Kotake M, Ono Y, Kato T, Oda N, Hayakawa N, et al. Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocr J, 2006. 53(4): p. 503-10. https://doi.org/10.1507/endocrj.K06-001
  • Al-Timimi, D.J. and A.F. Ali, Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control. J Clin Diagn Res, 2013. 7(12): p. 2686-8. https://doi.org/10.7860/JCDR/2013/6712.3733
  • Olt, S. Relationship between vitamin D and glycemic control in patients with type 2 diabetes mellitus. Int J Clin Exp Med, 2015. 8(10): p. 19180-3.
  • Taniura H, Ito M, Sanada N, Kuramoto N, Ohno Y, Nakamichi N, et al. Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J Neurosci Res, 2006. 83(7): p. 1179-89. https://doi.org/10.1002/jnr.20824
  • Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, et al. Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury. PLOS ONE, 2013. 8(5). https://doi.org/10.1371/journal.pone.0065034
  • Chabas JF, Alluin O, Rao G, Garcia S, Lavaut MN, Risso JJ, et al. Vitamin D2 potentiates axon regeneration. J Neurotrauma, 2008. 25(10): p. 1247-56. https://doi.org/10.1089/neu.2008.0593
  • Shehab D, Al-Jarallah K, Abdella N, Mojiminiyi OA, Al Mohamedy H. Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus. Med Princ Pract, 2015. 24(3): p. 250-6. https://doi.org/10.1159/000375304
  • Pinelli NR, Jaber LA, Brown MB, Herman WH. Serum 25-hydroxy vitamin d and insulin resistance, metabolic syndrome, and glucose intolerance among Arab Americans. Diabetes Care, 2010. 33(6): p. 1373-5. https://doi.org/10.2337/dc09-2199
  • Alam U, Nelson AJ, Cuthbertson DJ, Malik RA. An update on vitamin D and B deficiency in the pathogenesis and treatment of diabetic neuropathy: a narrative review. Future Neurology, 2018. 13(3): p. 135-142. https://doi.org/10.2217/fnl-2017-0034
  • Putz Z, Martos T, Németh N, Körei AE, Vági OE, Kempler MS, et al. Is there an association between diabetic neuropathy and low vitamin D levels? Curr Diab Rep, 2014. 14(10): p. 014-0537. https://doi.org/10.1007/s11892-014-0537-6
  • Timar B, Timar R, Gaiță L, Oancea C, Levai C, Lungeanu D. The Impact of Diabetic Neuropathy on Balance and on the Risk of Falls in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study. PLOS ONE, 2016. 11(4). https://doi.org/10.1371/journal.pone.0154654
  • Muir, S.W. and M. Montero-Odasso, Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc, 2011. 59(12): p. 2291-300. https://doi.org/10.1111/j.1532-5415.2011.03733.x
  • Akdeniz S, Hepguler S, Öztürk C, Atamaz FC. The relation between vitamin D and postural balance according to clinical tests and tetrax posturography. J Phys Ther Sci, 2016. 28(4): p. 1272-7. https://doi.org/10.1589/jpts.28.1272
  • Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA. Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes? Diabet Med, 2012. 29(1): p. 43-9. https://doi.org/10.1111/j.1464-5491.2011.03510.x
  • Alamdari A, Mozafari R, Tafakhori A, Faghihi-Kashani S, Hafezi-Nejad N, Sheikhbahaei S, et al. An inverse association between serum vitamin D levels with the presence and severity of impaired nerve conduction velocity and large fiber peripheral neuropathy in diabetic subjects. Neurol Sci, 2015. 36(7): p. 1121-6. https://doi.org/10.1007/s10072-015-2207-0
  • Celikbilek A, Gocmen AY, Tanik N, Borekci E, Adam M, Celikbilek M, et al. Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey. Acta Neurol Belg, 2015. 115(1): p. 47-52. https://doi.org/10.1007/s13760-014-0304-0
  • Shillo P, Selvarajah D, Greig M, Gandhi R, Rao G, Wilkinson ID, et al. Reduced vitamin D levels in painful diabetic peripheral neuropathy. Diabet Med, 2019. 36(1): p. 44-51. https://doi.org/10.1111/dme.13798
  • Bell, D.S., Reversal of the Symptoms of Diabetic Neuropathy through Correction of Vitamin D Deficiency in a Type 1 Diabetic Patient. Case Rep Endocrinol, 2012. 165056(10): p. 12. https://doi.org/10.1155/2012/165056
  • Dalgård C, Petersen MS, Weihe P, Grandjean P. Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. Diabetes Care, 2011. 34(6): p. 1284-8. https://doi.org/10.2337/dc10-2084
  • Basit A, Basit KA, Fawwad A, Shaheen F, Fatima N, Petropoulos IN, et al. Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Research and Care, 2016. 4(1): p. e000148. https://doi.org/10.1136/bmjdrc-2015-000148
  • Anand P, Terenghi G, Warner G, Kopelman P, Williams-Chestnut RE, Sinicropi DV. The role of endogenous nerve growth factor in human diabetic neuropathy. Nat Med, 1996. 2(6): p. 703-7. https://doi.org/10.1038/nm0696-703
  • Ozuguz U, Oruc S, Ulu MS, Demirbas H, Acay A, Coker B, et al. Does vitamin D have any role in the improvement of diabetic peripheral neuropathy in type 1 diabetic patients? J Endocrinol Invest, 2016. 39(12): p. 1411-1417. https://doi.org/10.1007/s40618-016-0509-6
  • Pinzon, R.T., A. Tjung, and A.W. Pradana, Is there any relations hip between vitamin d levels and the severity of diabetic peripheral neuropathy? Romanian Journal of Neurology, 2020. 19(2). https://doi.org/10.37897/RJN.2020.2.6
  • Soderstrom LH, Johnson SP, Diaz VA, Mainous AG, 3rd. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES. Diabet Med, 2012. 29(1): p. 50-5. https://doi.org/10.1111/j.1464-5491.2011.03379.x
  • Bilir B, Tulubas F, Bilir BE, Atile NS, Kara SP, Yildirim T, et al. The association of vitamin D with inflammatory cytokines in diabetic peripheral neuropathy. J Phys Ther Sci, 2016. 28(7): p. 2159-63. https://doi.org/10.1589/jpts.28.2159
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Original Articles
Yazarlar

Murat Güntel 0000-0002-5885-7571

Alper Uysal 0000-0002-4114-1649

Yayımlanma Tarihi 19 Ağustos 2021
Gönderilme Tarihi 29 Mayıs 2021
Kabul Tarihi 27 Haziran 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 12 Sayı: 43

Kaynak Göster

Vancouver Güntel M, Uysal A. Diyabetik Periferik Nöropati ve Vitamin D İlişkisi. mkutfd. 2021;12(43):100-5.