Diyabet Hastalarında Hematüri Sıklığı ve Albüminüri ile İlişkisi

Yıl 2022, Cilt: 13 Sayı: 45, 80 - 85, 07.04.2022

Müge Özsan Yılmaz , Serdar Doğan , Faruk Hilmi Turgut

https://doi.org/10.17944/mkutfd.1014796

Öz

Amaç: Bu çalışmanın amacı diyabetik hastalarda hematüri sıklığını belirlemek ve bunun mevcut klinik ve laboratuvar değişkenleriyle özellikle de albüminüri ile olan ilişkisini değerlendirmektir.
Yöntem: Çalışmaya aynı başvuruda tam idrar tahlili ve idrar albümin/kreatinin oranı istenen 302 diyabet hastası dahil edilmiştir. Hastalar hematürisi olan ve hematürisi olmayan hastalar şeklinde iki gruba ayrılmıştır. Hastalara ait hemogram sonuçları, spot idrar albümin ve kreatinin düzeyleri, serum glukoz, total kolesterol, LDL kolesterol, trigliserid, BUN, kreatinin, albumin, sodyum ve potasyum sonuçlarıyla ALT ve AST enzim aktiviteleri, tam idrar tahlili, serum CRP düzeyleri, HbA1c düzeyleri ve tahmini glomerüler filtrasyon hızı (eGFR) düzeyleri retrospektif olarak değerlendirilmiştir.
Bulgular: Çalışmaya dahil edilen hastaların yaş ortalaması 54±13 yıl bulunmuştur. Hastaların %23.5 (n=71)’inde hematüri saptanmıştır. Çalışmaya dahil edilen 229 (%75.8) hastanın normoalbüminürik, 52 (%17.2) hastanın mikroalbüminürik, 21 (%7) hastanın ise makroalbuminürik olduğu görülmüştür. Hematürisi olan diyabetik hastaların idrar albüminüri değerleri hematürisi olmayanlara göre istatistiksel olarak anlamlı şekilde yüksek saptandı (14.23 mg/g vs 1.96 mg/g, p<0.001). Makroalbüminüri görülme oranı hematürisi olan hastalarda olmayanlara göre istatistiksel olarak anlamlı şekilde yüksek bulunmuştur. Hematürisi olan hastaların ortalama eGFR değerleri hematürisi olmayan hastalar ile karşılaştırıldığında daha düşük bulunmuştur. Ancak istatiksel anlamlılığa ulaşmamıştır (p=0.055).
Sonuç: Diyabetik hastalarda hematüri sık görülmektedir ve hematüri diyabetik böbrek hastalığının bir bulgusu olarak karşımıza çıkabilir. Hematürisi olan hastalarda albüminüri değerleri daha yüksek ve eGFR değerleri daha düşük bulunmuştur.

Anahtar Kelimeler

diyabet, hematüri, albüminüri

Frequency of Haematuria in Diabetic Patients and Relationship with Albuminuria

Öz

Objective: The aim of this study was to determine the frequency of hematuria in diabetic patients and to evaluate its relationship with current clinical and laboratory variables, especially albuminuria.
Methods: Three hundred and two diabetic patients were included in the study. The patients were divided into two groups as those with and without hematuria. Hemogram, spot urine albumin and creatinine, serum glucose, total cholesterol, LDL cholesterol, triglyceride, BUN, creatinine, albumin, sodium, potassium results, ALT and AST enzyme activities, complete urinalysis, serum CRP levels, HbA1c levels and estimated glomerular filtration rate (eGFR) levels of patients were evaluated retrospectively.
Results: The mean age of the patients was 54±13 years. Hematuria was found in 23.5% (n=71) of the patients. It was observed that 229 (75.8%) patients included in the study were normoalbuminuric, 52 (17.2%) patients were microalbuminuric, and 21 (7%) patients were macroalbuminuric. The urinary albuminuria values of diabetic patients with hematuria were found to be statistically significantly higher than those without hematuria (14.23 mg/d vs 1.96 mg/d, p<0.001). The incidence of macroalbuminuria was found to be statistically significantly higher in patients with hematuria than in patients without hematuria. The mean eGFR values of patients with hematuria were found to be lower compared to patients without hematuria. However, it did not reach statistical significance (p=0.055).
Conclusion: Hematuria is common in diabetic patients and hematuria may be a manifestation of diabetic kidney disease. In patients with hematuria, albuminuria values were higher and eGFR values were lower.

Anahtar Kelimeler

diabetes, albuminuria, haematuria

Kaynakça

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