Psoriasis triggered by bupropion in a patient with major depression

Yıl 2013, , 186 - 8, 01.04.2013

Abdullah Akpınar Murat Ali Ceyhan Ayşe Rümeysa Yaman

https://doi.org/10.5455/jmood.20130905044624

Öz

Despite extensive use of antidepressants in patients with psoriasis, there have been very few case reports of antidepressant-related psoriasis. In this case, a patient with major depression who was treated with varies types of antidepressants including fluoxetine, reboxetine, bupropion, and venlafaxine, and in who pre-existing psoriatic lesions were aggravated after bupropion treatment. Clinicians should be aware of the influence of bupropion to aggravate pre-existing psoriasis.

Anahtar Kelimeler

psoriasis, major depression, bupropion, antidepressant, side effect

Major depresyon hastasında bupropion tedavisiyle tetiklenen psöriasis

Öz

Antidepresanların psöriazis hastalarında sıkça kullanılmalarına karşın, çok az sayıda antidepresanlar ile ilişkili psöriazis vakaları bulunmaktadır. Bu olguda major depresyonu olan hasta, sıra ile fluoksetin, reboksetin, bupropion ve venlafaksin gibi farklı grup antidepresanlar ile tedavisi uygulanmıştır ve hastanın bupropion tedavisi sonrasında önceden var olan psöriatik lezyonları alevlenmiştir. Klinisyenler bupropionun daha önceden var olan psöriazisi alevlendirici etkilerinin farkında olmalıdır.

Anahtar Kelimeler

psöriazis, major depresyon, bupropion, antidepresan, yan etki

Kaynakça

• Bilac C, Ermertcan AT, Bilac DB, Deveci A, Horasan GD. The relationship between symptoms and patient characteristics among psoriasis patients. Indian J Dermatol Venereol. 2009;75:551.
• Basavaraj KH, Ashok NM, Rashmi R, Praveen TK. The role of drugs in the induction and/or exacerbation of psoriasis. Int J Dermatol. 2010;49:1351-61.
• Levine D, Gottlieb A. Evaluation and management of psoriasis: an internist’s guide. Med Clin North Am. 2009;93:1291-303.
• Dowlatshahi EA, Wakkee M, Herings RM, Hollestein LM, Nijsten T. Increased Antidepressant Drug Exposure in Psoriasis Patients: A Longitudinal Population-based Cohort Study. Acta Derm Venereol. 2013. doi: 10.2340/00015555-1566.
• Psoriasis triggered by bupropion in a patient with major depression Sharma N, Koranne RV, Singh RK. Psychiatric morbidity in psoriasis and vitiligo: a comparative study. J Dermatol. 2001;28:419-23.
• Surovik J, Riddel C, Chon SY. A case of bupropion-induced Stevens-Johnson syndrome with acute psoriatic exacerbation. J Drugs Dermatol. 2010;9:1010-2
• Cox NH, Gordon PM, Dodd H. Generalized pustular and erythrodermic psoriasis associated with bupropion treatment. Br J Dermatol. 2002;146:1061-3.
• Gómez-Fernández C, Herranz Pinto P, Casado Verrier B, Sendagorta Cudós E, Beato-Merino MJ, Jiménez MC. Drug eruption and exacerbation of psoriasis related to bupropion. Eur J Dermatol. 2011;21:120-1.
• Modell JG, Boyce S, Taylor E, Katholi C. Treatment of atopic dermatitis and psoriasis vulgaris with bupropion-SR: a pilot study. Psychosom Med. 2002;64:835-40.