Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri

Öz

Bitkilerden elde edilen, özellikle fenolik yapıdaki kimyasal maddeler, antioksidan özellikleri sayesinde reaktif oksijen türlerini inaktive ederek oksidatif hasarın önlenmesinde ve giderilmesinde önemli rol oynamaktadırlar. Buna karşın günümüzde, bitkisel ürünlerin çoğunun yapıları ve biyolojik etkinlikleri yeterince aydınlatılamamış olup, birçok bitkisel antioksidan maddenin toksisitesi ve insan sağlığına olan zararlarlarıyla ilgili çalışmalar yeterli değildir. Bu çalışma, Mentha longifolia L. Hudson ssp. longifolia bitkisinden izole edilen iki fenolik bileşik olan Apigenin-7-O-glikozit (A7G) ile Apigenin-7-O-rutinozit (A7R)’in genotoksik ve anti-genotoksik etkilerinin belirlenmesi üzerine tasarlanmıştır. İki fenolik bileşiğin, insan lenfosit hücrelerinde aflatoksin B₁’e (AFB₁) karşı genotoksik ve anti-genotoksik etkileri kardeş kromatid değişimi testi ile araştırılmıştır. Çalışma sonuçları A7G ve A7R’nin güçlü anti-genotoksik özelliklerinin olduğunu göstermiştir. 

Anahtar Kelimeler

• Mentha longifolia,Apigenin-7-O-glikozit,Apigenin-7-O-rutinozit,Aflatoksin B1,Kardeş Kromatid Değişimi

Genotoxic potentials of apigenin-7-O-glucoside and apigenin-7-O-rutinoside isolated from Mentha longifolia (L.) Huds. ssp. Longifolia

Öz

Particularly the chemicals in phenolic structure obtained from plants play an important role in preventing and eliminating the oxidative damage by inactivating the reactive oxygen species due to their antioxidant properties. However, today the structures of the most herbal products and their biological activities have not been illuminated adequately; studies on the toxicity of the many herbal antioxidants and damage to human health are also not investigated properly.  This study was designed to evaluate the genotoxic and anti- genotoxic effects of two phenolic compounds, Apigenin 7-O-glucoside (A7G) and Apigenin 7-O-rutinoside (A7R)  which are isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The genotoxic and anti- genotoxic effects of two compounds in human lymphocytes cells were investigated by sister chromatid exchanges (SCEs) test system against aflatoxin B₁ (AFB₁). The results showed that A7G and A7R have strong anti-genotoxic properties.

Anahtar Kelimeler

• Mentha longifolia,Apigenin 7-O-glucoside,Apigenin 7-O-rutinoside,Aflatoxin B1,Sister Chromatid Exchanges

Kaynakça

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