Mentha longıfolia L. Hudson ssp. longifolia’dan Elde Edilen Apigenin-7-O- glukozit ve Apigenin-7-O-rutinozit’in Genotoksik Potansiyelleri

Yıl 2017, Cilt: 5 Sayı: 1, 413 - 418, 01.06.2017

Selçuk Çeker , Furkan Orhan Medine Güllüce Güleray Ağar

https://doi.org/10.18586/msufbd.295598

Öz

Bitkilerden
elde edilen, özellikle fenolik yapıdaki kimyasal maddeler, antioksidan
özellikleri sayesinde reaktif oksijen türlerini inaktive ederek oksidatif
hasarın önlenmesinde ve giderilmesinde önemli rol oynamaktadırlar. Buna karşın
günümüzde, bitkisel ürünlerin çoğunun yapıları ve biyolojik etkinlikleri
yeterince aydınlatılamamış olup, birçok bitkisel antioksidan maddenin
toksisitesi ve insan sağlığına olan zararlarlarıyla ilgili çalışmalar yeterli
değildir. Bu çalışma, Mentha longifolia L.
Hudson ssp. longifolia bitkisinden
izole edilen iki fenolik bileşik olan Apigenin-7-O-glikozit
(A7G) ile Apigenin-7-O-rutinozit
(A7R)’in genotoksik ve anti-genotoksik etkilerinin belirlenmesi üzerine
tasarlanmıştır. İki fenolik bileşiğin, insan lenfosit hücrelerinde aflatoksin B₁’e
(AFB₁) karşı genotoksik ve anti-genotoksik
etkileri kardeş kromatid değişimi testi ile araştırılmıştır. Çalışma sonuçları
A7G ve A7R’nin güçlü anti-genotoksik özelliklerinin olduğunu göstermiştir. 

Anahtar Kelimeler

Mentha longifolia, Apigenin-7-O-glikozit, Apigenin-7-O-rutinozit, Aflatoksin B1, Kardeş Kromatid Değişimi

Genotoxic potentials of apigenin-7-O-glucoside and apigenin-7-O-rutinoside isolated from Mentha longifolia (L.) Huds. ssp. Longifolia

Öz

Particularly
the chemicals in phenolic structure obtained from plants play an important role
in preventing and eliminating the oxidative damage by inactivating the reactive
oxygen species due to their antioxidant properties. However, today the
structures of the most herbal products and their biological activities have not
been illuminated adequately; studies on the toxicity of the many herbal
antioxidants and damage to human health are also not investigated
properly.  This study was designed to
evaluate the genotoxic and anti- genotoxic effects of two phenolic compounds, Apigenin 7-O-glucoside (A7G) and Apigenin 7-O-rutinoside (A7R)  which are isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The genotoxic and anti- genotoxic effects of two
compounds in human lymphocytes cells were investigated by sister chromatid
exchanges (SCEs) test system against aflatoxin B₁ (AFB₁).
The results showed that A7G and A7R have strong anti-genotoxic properties.

Anahtar Kelimeler

Mentha longifolia, Apigenin 7-O-glucoside, Apigenin 7-O-rutinoside, Aflatoxin B1, Sister Chromatid Exchanges

Kaynakça

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