Giant wart on the tongue

Öz

Verruca vulgaris is a benign infection caused by the human papillomavirus (HPV). The lesions appear primarily on the cutaneous surfaces; however, mucosal involvement is less frequent. The typical presentation is asymptomatic papules varying in size and number. The differential diagnosis includes a diverse list of benign and malignant conditions. Herein, we present a 65-year-old male patient with an asymptomatic cauliflower-like mass on the tongue incidentally observed during internal medicine physical examination. The excisional biopsy revealed verruca vulgaris, and no new lesions were detected in the follow-up.

Anahtar Kelimeler

• Oral mucosa
• Human Papillomavirus
• Verruca vulgaris
• Wart
• Verrucous carcinoma

Dil üzerinde dev siğil

Öz

Verruka vulgaris, insan papilloma virüsünün (HPV) neden olduğu benign bir enfeksiyondur. Lezyonlar öncelikle kutanöz yüzeylerde görülür; bununla birlikte, mukozal tutulum daha az sıklıkta görülmektedir. Tipik görünüm, boyut ve sayı olarak değişkenlik gösteren asemptomatik papüllerdir. Ayırıcı tanı, iyi huylu ve kötü huylu çeşitli durumların bir listesini içerir. Bu yazıda, dahiliye fizik muayenesinde tesadüfen dilde karnabahar benzeri asemptomatik kitle saptanan 65 yaşında bir erkek hasta sunulmaktadır. Eksizyonel biyopsi verruka vulgaris olarak sonuçlandı ve takiplerinde yeni lezyon izlenmedi.

Anahtar Kelimeler

• oral mukoza
• insan papillomavirusu
• verruka vulgaris
• siğil
• verrüköz karsinom

Kaynakça

1. Pina AR, Fonseca FP, Flavia-Sirotheau-Correa Pontes, et al. Benign epithelial oral lesions-association with human papillomavirus. Med Oral Patol Oral Cir Bucal 2019;24:e290-e5.
2. Alramadhan SA, Fitzpatrick SG, Bhattacharyya I, Islam MN, Cohen DM. Changing trends in benign human papillomavirus (HPV) related epithelial neoplasms of the oral cavity: 1995-2015. Head Neck Pathol 2022;16:738-45.
3. Graham SV. The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review. Clin Sci (Lond) 2017;131:2201-21.
4. Ural A, Arslan S, Ersoz S, Deger B. Verruca vulgaris of the tongue: a case report with literature review. Bosn J Basic Med Sci 2014;14:136-8.
5. Betz SJ. HPV-related papillary lesions of the oral mucosa: a review. Head Neck Pathol 2019;13:80-90.
6. Tam S, Fu S, Xu L, et al. The epidemiology of oral human papillomavirus infection in healthy populations: A systematic review and meta-analysis. Oral Oncol 2018;82:91-9.
7. Abbey LM, Page DG, Sawyer DR. The clinical and histopathologic features of a series of 464 oral squamous cell papillomas. Oral Surg Oral Med Oral Pathol 1980;49:419-28.
8. Mattoo A, Bhatia M. Verruca vulgaris of the buccal mucosa: A case report. J Cancer Res Ther 2018;14:454-6.

9. Nagaraj M. Verruca vulgaris of the tongue. J Maxillofac Oral Surg 2013;12:329-32.
10. Shahrabi Farahani S, Treister NS, Khan Z, Woo SB. Oral verruciform xanthoma associated with chronic graft-versus-host disease: a report of five cases and a review of the literature. Head Neck Pathol 2011;5:193-8.
11. Atullah JK, Murad N, Khitab U. Oral verruca vulgaris: a rare case with transformation of papilloma to well differentiated oral squamous cell carcinoma. Pakistan Oral and Dental Journal. 2010;30.
12. Fiorillo L, Cervino G, Surace G, et al. Human papilloma virus: current knowledge and focus on oral health. Biomed Res Int 2021;2021:6631757.
13. Syrjanen S, Lodi G, Von Bultzingslowen I, et al. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review. Oral Dis 2011;17:58-72.