Damakta ve gingivada malin melanom: Nadir bir lokalizasyon

Yıl 2020, , 52 - 56, 30.06.2020

Dua Cebeci , Şirin Yaşar , Yeşim Doğan Sabuncuoğlu Pembegul Güneş

https://doi.org/10.33204/mucosa.723907

Öz

Primer malin melanom, melanositlerin çoğalmasından kaynaklanan nadir ve agresif bir neoplazmdır. Oral mukozal melanom, dokuları ağız boşluğunun diğer malin tümörlerinden daha kolay metastaz yapma ve istila etme eğiliminde olan nadir bir malinitedir. Bu tümörler ağız boşluğunun herhangi bir yerinde bulunmakta; bununla birlikte sert damak ve maksiller alveoler mukozayı daha sık etkilemektedir. Mukozal melanomların çoğu, bukalemun gibidir ve birçok melanositik lezyonla karışabilir. Genellikle erken evrelerde asemptomatiktirler ve pigmentli bir yama veya şişlik, ülserasyon, kanama veya dişlerin kaybı gibi belirtilerle, tanıyı geciktiren bir kitle olarak ortaya çıkarlar. Bu makalede 79 yaşında kadın hastada maksiller ön gingivada yerleşim gösteren oral malin melanom olgusunu sunuyoruz. Histopatolojik olarak tanıyı doğrulamak için imünohistokimya ve özel boyalar yapıldı.

Anahtar Kelimeler

mukozal melanom, pigmentli lezyonlar, ağız boşluğu

Destekleyen Kurum

destekleyen kurum yoktur

Malignant melanoma at the hard palate and gingiva: a rare localization

Öz

Primary malignant melanoma is a rare and aggressive neoplasm that originates from the proliferation of melanocytes. Oral mucosal melanoma is a rare malignancy that tends to metastasize and to invade tissues more easily than other malignant tumors of the oral cavity. These tumors can be found anywhere in the oral cavity; however, they affect the hard palate and maxillary alveolar mucosa more frequently. Most mucosal melanomas are like chameleons and may be confused with many melanocytic lesions. In general, they are asymptomatic in the early stages and are presented as a mass that delays diagnosis until signs of a pigmented patch or swelling, ulceration, bleeding, or loosening of the teeth. In this article, we present a case of malignant melanoma of the maxillary anterior gingiva in a 79-year-old female patient. Immunohistochemistry and special staining were performed to

confirm the diagnosis histopathologicaly.

Anahtar Kelimeler

mucosal melanoma, pigmented lesions, oral cavity

Kaynakça

• 1. Manigandan T, Sagar GV, Amudhan A, Hemalatha VT, Babu NA. Oral malignant melanoma: A case report with review of literature. Contemp Clin Dent 2014;5:415-8.
• 2. Ashok S, Damera S, Ganesh S, Karri R. Oral malignant melanoma. J Oral Maxillofac Pathol 2020;24(Suppl 1):82-5.
• 3. Femiano F, Lanza A, Buonaiuto C, Gombos F, Di Spirit F, Cirillo N. Oral malignant melanoma: a review of the literature. Journal of Oral Pathology & Medicine 2008;37:383-8.
• 4. Zito PM, Mazzoni T. Cancer, oral melanoma. https://www.ncbi.nlm.nih.gov/books/NBK513276/
• 5. Thakur SK, Jha S, Singh S, Yadav A. Primary malignant melanoma of maxillary gingiva. Indian J Surg 2014;76:241-2.
• 6. Ahmadi-Motamayel F, Falsafi P, Baghaei F. Report of a rare and aggressive case of oral malignant melanoma. Oral Maxillofac Surg 2013;17:47-51.
• 7. Reddy B, Sridhar GR, Anuradha CH, Chandrasekhar P, Lingamaneni KP. Malignant melanoma of the mandibular gingiva: A rare occurrence. Indian J Dent Res 2010;21:302-5.
• 8. Rathore RS, Phulari RG, Vasavada DG, Patel DK. A rare and extensive case of oral malignant melanoma involving mandibular gingiva. J Clin Diagn Res 2016;10:11-2.
• 9. Rani GS, Kumar TV, Kolasani B, Begum MR, Priya Srinivasan A. Primary malignant melanoma of maxilla: report of a case with discussion. Case Rep Dent 2014;2014:624306.
• 10. Tchernev G, Lotti T, Wollina U. Palatal melanoma: “The Silent Killer”. Open Access Maced J Med Sci 2018;6:364-6.
• 11. Munde A, Juvekar MV, Karle RR, Wankhede P. Malignant melanoma of the oral cavity: Report of two cases. Contemp Clin Dent 2014;5:227-30.
• 12. Kim BJ, Kim H, Chang Y, Kwon K, Cho S. Primary amelanotic melanoma of the mandibular gingiva. Arch Craniofac Surg 2020;21:132-6.
• 13. Ebenezer J. Malignant melanoma of the oral cavity. Indian J Dent Res 2006;17:94.
• 14. Deyhimi P, Razavi SM, Shahnaseri S, Khalesi S, Homayoni S, Tavakoli P. Rare and extensive malignant melanoma of the oral cavity: Report of two cases. J Dent (Shiraz) 2017;18:227-33.
• 15. Panda S, Dash S, Besra K, Samantaray S, Pathy PC, Rout N. Clinicopathological study of malignant melanoma in a regional cancer center. Indian J Cancer 2018;55:292-6.