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Howthorn (Crataegus): Nature’s Little Miracle for Health!

Yıl 2024, , 450 - 458, 30.09.2024
https://doi.org/10.31020/mutftd.1486249

Öz

The fruit, leaves and flowers obtained from the hawthorn plant have been used in traditional medicine practices for centuries, thanks to the positive health effects of the bioactive components it contains. Hawthorn; It is a plant rich in species diversity that can grow in Asia, Europe, Africa and America. The type of wheat and the geographical region where it grows affect its chemical composition. Extracts obtained from the fruit, leaves and flowers of this plant contain various bioactive components. More than 300 chemical compounds have been isolated from the hawthorn plant. The main chemical components of the plant are flavonoids and organic acids. It is thought that these bioactive components contained in it may be useful in the prevention and treatment of diseases. The beneficial effects of hawthorn extract have been shown in the treatment and prevention of cardiovascular diseases, which are the leading causes of death in the world. Studies have shown that hawthorn extract increases glucose entry into the cell through GLUT4 expression. Therefore, it has been suggested that it can be used in the treatment of Diabetes mellitus (DM) and reducing its complications. In in-vitro and in-vivo studies, the recipient; anti-oxidant, anti-microbial, anti-hypertensive, anti-carcinogenic, etc. effects have been shown. Considering that hawthorn consumption can strengthen or inhibit illumination, the person using the drug should consume it under the supervision of a physician. The aim of this review is to provide information about the chemical components and potential benefits of hawthorn plant and to contribute to the development of therapeutic formulations and food applications.

Kaynakça

  • 1. Zhang J, et al. Food applications and potential health benefits of hawthorn. Foods 2022;11(18):2861.
  • 2. Nazhand A, et al. Hawthorn (crataegus spp.): An updated overview on its beneficial properties. Forests 2020;11(5):564.
  • 3. Attard E, Attard H. Hawthorn: crataegus oxyacantha, crataegus monogyna and related species. In nonvitamin and nonmineral nutritional supplements. Academic press; 2019. pp: 289-293.
  • 4. Martinelli F, et al. Botanical, phytochemical, anti-microbial and pharmaceutical characteristics of hawthorn (crataegus monogyna jacq.), Rosaceae. Molecules 2021;26(23):7266.
  • 5. Cui M, et al. Traditional uses, phytochemistry, pharmacology, and safety concerns of hawthorn (crataegus genus): A comprehensive review. Journal of ethnopharmacology 2023;319(2):117229.
  • 6. Li T, at al. Biological properties and potential application of hawthorn and its major functional components: A review. Journal of functional foods 2022;90:104988.
  • 7. Özdemir GB et al. Volatile aroma compounds and bioactive compounds of hawthorn vinegar produced from hawthorn fruit (crataegus tanacetifolia (lam.) Pers.) Journal of food biochemistry 2022;46(3):e13676.
  • 8. Dehghani S, mehri S, hosseinzadeh H. The effects of crataegus pinnatifida (chinese hawthorn) on metabolic syndrome: A review. Iran J basic med sci 2019;22(5):460-468.
  • 9. Gheitasi I, et al. Molecular mechanisms of hawthorn extracts in multiple organs disorders in underlying of diabetes: A review. Int J endocrinol 2022;14.
  • 10. Dokumacı Y, et al. Determination of some physical and chemical properties of common hawthorn (crataegus monogyna jacq. Var. Monogyna). Erwerbs-obstbau 2021;63(1):99-106.
  • 11. Lyu Q, et al. Expanding annotation of chemical compounds in hawthorn fruits and their variations in thermal processing using integrated mass spectral similarity networking. Food Research International 2023;172:113114.
  • 12. Luan M, et al. Advances in anti-inflammatory activity, mechanism and therapeutic application of ursolic acid. Mini reviews in medicinal chemistry 2022;22(3):422-436.
  • 13. Huang X, et al. Lignans from the seeds of chinese hawthorn (crataegus pinnatifida var. Major NE br.) Against β-amyloid aggregation. Natural product research 2018;32(14):1706-1713.
  • 14. Guo W, et al. Chemical composition, biological activities, and quality standards of hawthorn leaves used in traditional chinese medicine: a comprehensive review. Front pharmacol 2023;20(14):1275244.
  • 15. Cosmulescu S, et al. Content in organic acids of mespilus spp. And crataegus spp. Genotypes. Notulae botanicae horti agrobotanici cluj-napoca 2020;48(1):171-176.
  • 16. Bekbolatova E, et al. Phenolic composition and antioxidant potential of different organs of kazakh crataegus almaatensis pojark: A comparison with the european crataegus oxyacantha L. Flowers. Open chemistry 2020;16(1):415-426.
  • 17. Kim E, jang E, lee JH. Potential roles and key mechanisms of hawthorn extract against various liver diseases. Nutrients 2022;14(4):867.
  • 18. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, USDA [Internet].[updated 2024 feb 19; cited 2018 may 2]. Available from: https://fdc.nal.usda.gov/fdc-app.html#/food-details/475607/nutrients
  • 19. Zhang S, et al. Botany, traditional uses, phytochemistry and pharmacological activity of crataegus pinnatifida (chinese hawthorn): A review. Journal of pharmacy and pharmacology 2022;74(11):1507-1545.
  • 20. Wu M, et al. Roles and mechanisms of hawthorn and its extracts on atherosclerosis: a review. Frontiers in pharmacology 2020;11:118.
  • 21. Kemppainen L, et al. Use of complementary and alternative medicine in europe: health-related and sociodemographic determinants. Scandinavian journal of public health 2018;46(4):448-455.
  • 22. Crisan E, Patil VK. Neuromuscular complications of statin therapy. Current neurology and neuroscience reports 2020;20:1-7.
  • 23. Zhou XL, et al. Clinical efficacy of traditional Chinese medicinal preparations containing hawthorn on hyperlipidemia: A Meta-Analysis of Randomized Controlled Trials, 28 July 2022, PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-1880825/v1
  • 24. Cheng F, et al. Ethanol extract of chinese hawthorn (crataegus pinnatifida) fruit reduces inflammation and oxidative stress in rats with doxorubicin-induced chronic heart failure. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 2020;24(26):e926654.
  • 25. Rababa'h AM, et al. The effect of hawthorn flower and leaf extract (crataegus spp.) On cardiac hemostasis and oxidative parameters in sprague dawley rats. Heliyon 2020;6(8):e04617.
  • 26. Cloud A, Vilcins D, Mcewen B. The effect of hawthorn (crataegus spp.) On blood pressure: a systematic review. Advances in integrative medicine 2020;7(3):167-175.
  • 27. Eggeling T, et al. Baseline severity but not gender modulates quantified Crataegus extract effects in early heart failure–a pooled analysis of clinical trials. Phytomedicine 2011;18(14):1214-1219.
  • 28. Brixius K.et al. Crataegus special extract WS® 1442 induces an endothelium-dependent, no-mediated vasorelaxation via enos-phosphorylation at serine 1177. Cardiovasc drugs ther 2006; 20: 177–184.
  • 29. Rieckeheer E, et al. Hawthorn special extract WS® 1442 increases red blood cell no-formation without altering red blood cell deformability. Phytomedicine 2011;19(1):20-24.
  • 30. Asher GN, et al. Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial. BMC complement altern med 2012;12:26.
  • 31. Sarantopoulos CN, et al. Elucidating the preadipocyte and its role in adipocyte formation: a comprehensive review. Stem cell rev and rep 2018;14:27-42.
  • 32. Wat E, et al. An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome. Phytomedicine 2018;42:112-125.
  • 33. Hu H, et al. The hypolipidemic effect of hawthorn leaf flavonoids through modulating lipid metabolism and gut microbiota in hyperlipidemic rats. Evidence-based complementary and alternative medicine 2022;30.
  • 34. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Benzie IFF, Wachtel-Galor S, editors. Boca Raton (FL): CRC Press/Taylor & Francis; 2011.
  • 35. Shatoor AS, et al. The hypocoagulant effect of crataegus aronia in rats entails vitamin k‐dependent and vitamin k‐independent effects. Journal of food biochemistry 2020;44(1):e13094.
  • 36. Pawlaczyk-Graja I. Polyphenolic-polysaccharide conjugates from flowers and fruits of single-seeded hawthorn (crataegus monogyna jacq.): Chemical profiles and mechanisms of anticoagulant activity, international journal of biological macromolecules 2018;116:869-879.
  • 37. Gao P, et al. Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using the activity-guided method. Food & function 2019;10(2):859-866.
  • 38. Li LZ, et al. Monoterpenes and flavones from the leaves of Crataegus pinnatifida with anticoagulant activities, Journal of Functional Foods 2015;12:237-245.
  • 39. Hatfield J, Saad S, Housewright C. Dietary supplements and bleeding. Proc (bayl univ med cent) 2022;35(6):802-807.
  • 40. Rigelsky JM, Sweet BV. Hawthorn: Pharmacology and therapeutic uses, American Journal of Health-System Pharmacy 2002; 59(5):417–422.
  • 41. Manukyan A, Lumlerdkij N, Heinrich M. Caucasian endemic medicinal and nutraceutical plants: in-vitro antioxidant and cytotoxic activities and bioactive compounds. Journal of pharmacy and pharmacology 2019;71(7):1152-1161.
  • 42. Xu Y, et al. Acetylated xylo-oligosaccharide from Hawthorn kernels inhibits colon cancer cells in vitro and in vivo. Journal of Functional Foods 2023;102:105436.
  • 43. Saeedi P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas, 9th editionsaeedi, pouya et al. Diabetes research and clinical practice 2019;157:107843. 44. Lien HM, et al. protective effect of hawthorn fruit extract against high fructose-induced oxidative stress and endoplasmic reticulum stress in pancreatic β-cells. Foods 2023; 12(6):1130.
  • 45. Gu W, et al. Hawthorn total flavonoids ameliorate ambient fine particulate matter-induced insulin resistance and metabolic abnormalities of lipids in mice. Ecotoxicology and Environmental Safety 2023;249:114456.
  • 46. Liu S, et al. Regulatory effects of hawthorn polyphenols on hyperglycemic, inflammatory, insulin resistance responses, and alleviation of aortic injury in type 2 diabetic rats. Food research international 2021;142:110239.
  • 47. Min Q, et al. Hawthorn leaf flavonoids protect against diabetes-induced cardiomyopathy in rats via pkc-α signaling pathway. Evidence-based complementary and alternative medicine 2017;8.
  • 48. Shi GJ, et al. In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature. Biomedicine & Pharmacotherapy 2019;109:1085-1099.
  • 49. Liu H. et al. Effect of dehydration techniques on bioactive compounds in hawthorn slices and their correlations with antioxidant properties. J. Food sci. Technol 2019;56:2446–2457.
  • 50. Liu G, et al. Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating tgf‐β1/smad2, nf‐κb, and AMPK signaling pathways. Phytotherapy research 2021; 35(9):5214-5226.
  • 51. Wang Y, et al. Hawthorn extract inhibited the pi3k/akt pathway to prolong the lifespan of drosophila melanogaster. Journal of food biochemistry 2022;46(8):e14169. 52. Coklar H, et al. Effect of freeze, oven and microwave pretreated oven drying on color, browning index, phenolic compounds and antioxidant activity of hawthorn (crataegus orientalis) fruit. Notulae botanicae horti agrobotanici cluj-napoca 2018;46(2):449-456.
  • 53. Gatadi S, Madhavi YV, Nanduri S. Nanoparticle drug conjugates treating microbial and viral infections: A review. Journal of molecular structure 2021;1228, 129750.
  • 54. Wang Z, et al. Antibacterial activity of xanthan-oligosaccharide against staphylococcus aureus via targeting biofilm and cell membrane. International journal of biological macromolecules 2020;153:539-544.
  • 55. Qin C, et al. Synthesis, physicochemical characterization, antibacterial activity, and biocompatibility of quaternized hawthorn pectin. Int J biol macromol 2022;213:1047-1056.
  • 56. Zhang LL, Zhang LF, Xu JG. Chemical composition, antibacterial activity and action mechanism of different extracts from hawthorn (crataegus pinnatifida bge.). Sci 2020;10(1):8876.
  • 57. Ramadan J, El hajj, R Khalil, M. Characterization of the risk factors associated with urinary tract infection (uti) in lebanon, and evaluation of the antibacterial activity of hawthorn extract against uti-causative bacteria. Bacterial Empıre 2022;5(3):e496.
  • 58. Kurkin VA, et al. Quantitative determination of total flavonoids in blood-red hawthorn fruit. Pharmaceutical chemistry journal 2020;54:36-39.
  • 59. Zeng L, et al. LC–MS based plasma metabolomics study of the intervention effect of different polar parts of hawthorn on hyperlipidemia rats. Journal of separation science 2021; 44(5):963-972.
  • 60. Niu Z, et al. Effect of hawthorn seed extract on the gastrointestinal function of rats with diabetic gastroparesis. South african journal of botany 2020;130:448-455.

Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!

Yıl 2024, , 450 - 458, 30.09.2024
https://doi.org/10.31020/mutftd.1486249

Öz

Alıç bitkisinden elde edilen meyve, yapraklar ve çiçekler, içerdiği biyoaktif bileşenlerinin sağlık üzerine olumlu etkileri sayesinde geleneksel tıp uygulamalarında yüzyıllardır kullanılmaktadır. Alıç; Asya, Avrupa, Afrika ve Amerika’da yetişebilen, tür çeşitliliği açısından zengin bir bitkidir. Alıcın türü ve yetiştiği coğrafi bölge, kimyasal bileşiminde etkili olmaktadır. Bu bitkinin meyve, yaprak ve çiçek kısmından elde edilen ekstraktlar çeşitli biyoaktif bileşenler içermektedir. Alıç bitkisinden 300’den fazla kimyasal bileşen izole edilmiştir. Bitkinin temel kimyasal bileşenleri flavonoidler ve organik asitlerdir. İçeriğinde bulunan bu biyoaktif bileşenlerin, hastalıklardan korunmada ve tedavide faydalı olabileceği düşünülmektedir. Dünyadaki ölüm nedenlerinin başında gelen kardiyovasküler hastalıkların tedavisinde ve önlenmesinde alıç ekstraktının yararlı etkileri gösterilmiştir. Yapılan çalışmalarda, alıç ekstraktının GLUT4 ekspresyonu ile hücreye glukoz girişini arttırdığı belirtilmiştir. Dolayısıyla Diabetes mellitus (DM)’ün tedavisinde ve komplikasyonlarının azaltılmasında kullanılabileceği öne sürülmüştür. Yapılan in-vitro ve in-vivo çalışmalarda alıcın; anti-oksidan, anti-mikrobiyal, anti-hipertansif, anti-kanserojenik vb. etkileri gösterilmiştir. Alıç tüketiminin, ilaçların etkisini güçlendirebileceği ya da engelleyebileceği göz önünde bulundurularak, ilaç kullanan kişilerin, alıcı hekim kontrolünde tüketmesi önerilmektedir. Bu derlemede amaç alıç bitkisinin kimyasal bileşenleri ile potansiyel faydaları hakkında bilgi vermek, terapötik formülasyonların ve gıda uygulamalarının geliştirilmesine katkı sunmaktır.

Kaynakça

  • 1. Zhang J, et al. Food applications and potential health benefits of hawthorn. Foods 2022;11(18):2861.
  • 2. Nazhand A, et al. Hawthorn (crataegus spp.): An updated overview on its beneficial properties. Forests 2020;11(5):564.
  • 3. Attard E, Attard H. Hawthorn: crataegus oxyacantha, crataegus monogyna and related species. In nonvitamin and nonmineral nutritional supplements. Academic press; 2019. pp: 289-293.
  • 4. Martinelli F, et al. Botanical, phytochemical, anti-microbial and pharmaceutical characteristics of hawthorn (crataegus monogyna jacq.), Rosaceae. Molecules 2021;26(23):7266.
  • 5. Cui M, et al. Traditional uses, phytochemistry, pharmacology, and safety concerns of hawthorn (crataegus genus): A comprehensive review. Journal of ethnopharmacology 2023;319(2):117229.
  • 6. Li T, at al. Biological properties and potential application of hawthorn and its major functional components: A review. Journal of functional foods 2022;90:104988.
  • 7. Özdemir GB et al. Volatile aroma compounds and bioactive compounds of hawthorn vinegar produced from hawthorn fruit (crataegus tanacetifolia (lam.) Pers.) Journal of food biochemistry 2022;46(3):e13676.
  • 8. Dehghani S, mehri S, hosseinzadeh H. The effects of crataegus pinnatifida (chinese hawthorn) on metabolic syndrome: A review. Iran J basic med sci 2019;22(5):460-468.
  • 9. Gheitasi I, et al. Molecular mechanisms of hawthorn extracts in multiple organs disorders in underlying of diabetes: A review. Int J endocrinol 2022;14.
  • 10. Dokumacı Y, et al. Determination of some physical and chemical properties of common hawthorn (crataegus monogyna jacq. Var. Monogyna). Erwerbs-obstbau 2021;63(1):99-106.
  • 11. Lyu Q, et al. Expanding annotation of chemical compounds in hawthorn fruits and their variations in thermal processing using integrated mass spectral similarity networking. Food Research International 2023;172:113114.
  • 12. Luan M, et al. Advances in anti-inflammatory activity, mechanism and therapeutic application of ursolic acid. Mini reviews in medicinal chemistry 2022;22(3):422-436.
  • 13. Huang X, et al. Lignans from the seeds of chinese hawthorn (crataegus pinnatifida var. Major NE br.) Against β-amyloid aggregation. Natural product research 2018;32(14):1706-1713.
  • 14. Guo W, et al. Chemical composition, biological activities, and quality standards of hawthorn leaves used in traditional chinese medicine: a comprehensive review. Front pharmacol 2023;20(14):1275244.
  • 15. Cosmulescu S, et al. Content in organic acids of mespilus spp. And crataegus spp. Genotypes. Notulae botanicae horti agrobotanici cluj-napoca 2020;48(1):171-176.
  • 16. Bekbolatova E, et al. Phenolic composition and antioxidant potential of different organs of kazakh crataegus almaatensis pojark: A comparison with the european crataegus oxyacantha L. Flowers. Open chemistry 2020;16(1):415-426.
  • 17. Kim E, jang E, lee JH. Potential roles and key mechanisms of hawthorn extract against various liver diseases. Nutrients 2022;14(4):867.
  • 18. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, USDA [Internet].[updated 2024 feb 19; cited 2018 may 2]. Available from: https://fdc.nal.usda.gov/fdc-app.html#/food-details/475607/nutrients
  • 19. Zhang S, et al. Botany, traditional uses, phytochemistry and pharmacological activity of crataegus pinnatifida (chinese hawthorn): A review. Journal of pharmacy and pharmacology 2022;74(11):1507-1545.
  • 20. Wu M, et al. Roles and mechanisms of hawthorn and its extracts on atherosclerosis: a review. Frontiers in pharmacology 2020;11:118.
  • 21. Kemppainen L, et al. Use of complementary and alternative medicine in europe: health-related and sociodemographic determinants. Scandinavian journal of public health 2018;46(4):448-455.
  • 22. Crisan E, Patil VK. Neuromuscular complications of statin therapy. Current neurology and neuroscience reports 2020;20:1-7.
  • 23. Zhou XL, et al. Clinical efficacy of traditional Chinese medicinal preparations containing hawthorn on hyperlipidemia: A Meta-Analysis of Randomized Controlled Trials, 28 July 2022, PREPRINT (Version 1) available at Research Square https://doi.org/10.21203/rs.3.rs-1880825/v1
  • 24. Cheng F, et al. Ethanol extract of chinese hawthorn (crataegus pinnatifida) fruit reduces inflammation and oxidative stress in rats with doxorubicin-induced chronic heart failure. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 2020;24(26):e926654.
  • 25. Rababa'h AM, et al. The effect of hawthorn flower and leaf extract (crataegus spp.) On cardiac hemostasis and oxidative parameters in sprague dawley rats. Heliyon 2020;6(8):e04617.
  • 26. Cloud A, Vilcins D, Mcewen B. The effect of hawthorn (crataegus spp.) On blood pressure: a systematic review. Advances in integrative medicine 2020;7(3):167-175.
  • 27. Eggeling T, et al. Baseline severity but not gender modulates quantified Crataegus extract effects in early heart failure–a pooled analysis of clinical trials. Phytomedicine 2011;18(14):1214-1219.
  • 28. Brixius K.et al. Crataegus special extract WS® 1442 induces an endothelium-dependent, no-mediated vasorelaxation via enos-phosphorylation at serine 1177. Cardiovasc drugs ther 2006; 20: 177–184.
  • 29. Rieckeheer E, et al. Hawthorn special extract WS® 1442 increases red blood cell no-formation without altering red blood cell deformability. Phytomedicine 2011;19(1):20-24.
  • 30. Asher GN, et al. Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial. BMC complement altern med 2012;12:26.
  • 31. Sarantopoulos CN, et al. Elucidating the preadipocyte and its role in adipocyte formation: a comprehensive review. Stem cell rev and rep 2018;14:27-42.
  • 32. Wat E, et al. An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome. Phytomedicine 2018;42:112-125.
  • 33. Hu H, et al. The hypolipidemic effect of hawthorn leaf flavonoids through modulating lipid metabolism and gut microbiota in hyperlipidemic rats. Evidence-based complementary and alternative medicine 2022;30.
  • 34. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Benzie IFF, Wachtel-Galor S, editors. Boca Raton (FL): CRC Press/Taylor & Francis; 2011.
  • 35. Shatoor AS, et al. The hypocoagulant effect of crataegus aronia in rats entails vitamin k‐dependent and vitamin k‐independent effects. Journal of food biochemistry 2020;44(1):e13094.
  • 36. Pawlaczyk-Graja I. Polyphenolic-polysaccharide conjugates from flowers and fruits of single-seeded hawthorn (crataegus monogyna jacq.): Chemical profiles and mechanisms of anticoagulant activity, international journal of biological macromolecules 2018;116:869-879.
  • 37. Gao P, et al. Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using the activity-guided method. Food & function 2019;10(2):859-866.
  • 38. Li LZ, et al. Monoterpenes and flavones from the leaves of Crataegus pinnatifida with anticoagulant activities, Journal of Functional Foods 2015;12:237-245.
  • 39. Hatfield J, Saad S, Housewright C. Dietary supplements and bleeding. Proc (bayl univ med cent) 2022;35(6):802-807.
  • 40. Rigelsky JM, Sweet BV. Hawthorn: Pharmacology and therapeutic uses, American Journal of Health-System Pharmacy 2002; 59(5):417–422.
  • 41. Manukyan A, Lumlerdkij N, Heinrich M. Caucasian endemic medicinal and nutraceutical plants: in-vitro antioxidant and cytotoxic activities and bioactive compounds. Journal of pharmacy and pharmacology 2019;71(7):1152-1161.
  • 42. Xu Y, et al. Acetylated xylo-oligosaccharide from Hawthorn kernels inhibits colon cancer cells in vitro and in vivo. Journal of Functional Foods 2023;102:105436.
  • 43. Saeedi P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas, 9th editionsaeedi, pouya et al. Diabetes research and clinical practice 2019;157:107843. 44. Lien HM, et al. protective effect of hawthorn fruit extract against high fructose-induced oxidative stress and endoplasmic reticulum stress in pancreatic β-cells. Foods 2023; 12(6):1130.
  • 45. Gu W, et al. Hawthorn total flavonoids ameliorate ambient fine particulate matter-induced insulin resistance and metabolic abnormalities of lipids in mice. Ecotoxicology and Environmental Safety 2023;249:114456.
  • 46. Liu S, et al. Regulatory effects of hawthorn polyphenols on hyperglycemic, inflammatory, insulin resistance responses, and alleviation of aortic injury in type 2 diabetic rats. Food research international 2021;142:110239.
  • 47. Min Q, et al. Hawthorn leaf flavonoids protect against diabetes-induced cardiomyopathy in rats via pkc-α signaling pathway. Evidence-based complementary and alternative medicine 2017;8.
  • 48. Shi GJ, et al. In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature. Biomedicine & Pharmacotherapy 2019;109:1085-1099.
  • 49. Liu H. et al. Effect of dehydration techniques on bioactive compounds in hawthorn slices and their correlations with antioxidant properties. J. Food sci. Technol 2019;56:2446–2457.
  • 50. Liu G, et al. Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating tgf‐β1/smad2, nf‐κb, and AMPK signaling pathways. Phytotherapy research 2021; 35(9):5214-5226.
  • 51. Wang Y, et al. Hawthorn extract inhibited the pi3k/akt pathway to prolong the lifespan of drosophila melanogaster. Journal of food biochemistry 2022;46(8):e14169. 52. Coklar H, et al. Effect of freeze, oven and microwave pretreated oven drying on color, browning index, phenolic compounds and antioxidant activity of hawthorn (crataegus orientalis) fruit. Notulae botanicae horti agrobotanici cluj-napoca 2018;46(2):449-456.
  • 53. Gatadi S, Madhavi YV, Nanduri S. Nanoparticle drug conjugates treating microbial and viral infections: A review. Journal of molecular structure 2021;1228, 129750.
  • 54. Wang Z, et al. Antibacterial activity of xanthan-oligosaccharide against staphylococcus aureus via targeting biofilm and cell membrane. International journal of biological macromolecules 2020;153:539-544.
  • 55. Qin C, et al. Synthesis, physicochemical characterization, antibacterial activity, and biocompatibility of quaternized hawthorn pectin. Int J biol macromol 2022;213:1047-1056.
  • 56. Zhang LL, Zhang LF, Xu JG. Chemical composition, antibacterial activity and action mechanism of different extracts from hawthorn (crataegus pinnatifida bge.). Sci 2020;10(1):8876.
  • 57. Ramadan J, El hajj, R Khalil, M. Characterization of the risk factors associated with urinary tract infection (uti) in lebanon, and evaluation of the antibacterial activity of hawthorn extract against uti-causative bacteria. Bacterial Empıre 2022;5(3):e496.
  • 58. Kurkin VA, et al. Quantitative determination of total flavonoids in blood-red hawthorn fruit. Pharmaceutical chemistry journal 2020;54:36-39.
  • 59. Zeng L, et al. LC–MS based plasma metabolomics study of the intervention effect of different polar parts of hawthorn on hyperlipidemia rats. Journal of separation science 2021; 44(5):963-972.
  • 60. Niu Z, et al. Effect of hawthorn seed extract on the gastrointestinal function of rats with diabetic gastroparesis. South african journal of botany 2020;130:448-455.
Toplam 58 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlığın Geliştirilmesi
Bölüm Derleme
Yazarlar

Emine Yurt 0009-0008-0175-5604

Kadriye Toprak 0000-0001-8706-8689

Yayımlanma Tarihi 30 Eylül 2024
Gönderilme Tarihi 18 Mayıs 2024
Kabul Tarihi 13 Eylül 2024
Yayımlandığı Sayı Yıl 2024

Kaynak Göster

APA Yurt, E., & Toprak, K. (2024). Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, 14(3), 450-458. https://doi.org/10.31020/mutftd.1486249
AMA Yurt E, Toprak K. Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. Eylül 2024;14(3):450-458. doi:10.31020/mutftd.1486249
Chicago Yurt, Emine, ve Kadriye Toprak. “Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi 14, sy. 3 (Eylül 2024): 450-58. https://doi.org/10.31020/mutftd.1486249.
EndNote Yurt E, Toprak K (01 Eylül 2024) Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 14 3 450–458.
IEEE E. Yurt ve K. Toprak, “Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!”, Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, c. 14, sy. 3, ss. 450–458, 2024, doi: 10.31020/mutftd.1486249.
ISNAD Yurt, Emine - Toprak, Kadriye. “Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 14/3 (Eylül 2024), 450-458. https://doi.org/10.31020/mutftd.1486249.
JAMA Yurt E, Toprak K. Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2024;14:450–458.
MLA Yurt, Emine ve Kadriye Toprak. “Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, c. 14, sy. 3, 2024, ss. 450-8, doi:10.31020/mutftd.1486249.
Vancouver Yurt E, Toprak K. Alıç (Crataegus): Sağlık İçin Doğanın Küçük Mucizesi!. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2024;14(3):450-8.
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