Sekosteroit hormon olarak D vitamini ve kanser ilişkisi

Yıl 2019, , 19 - 29, 28.01.2019

İbrahim Duman İsmail Ün

https://doi.org/10.31020/mutftd.456806

Cited By: 1

Öz

Klasik olarak kalsiyum
ve fosfat mekanizması üzerine olan etkilerinin yanı sıra antiproliferatif ve
immünomodülatör gibi özellikleri de olan D vitamini aslında bir seko-steroid
hormondur. Yakın dönem çalışmalar, D vitamini eksikliğinin otoimmün ve kardiyovasküler
hastalıkların yanı sıra kanser riskini artırabildiğini göstermiştir. D vitamini
eksikliği dünyada küresel bir salgın olarak bildirilmiştir. Buna ek olarak
osteoporoz ve düşme kırıkları için de bir risk faktörü olarak tanımlanmıştır. Diyetle alınan ve deride güneş aracılığı ile sentezlenen
D vitamininin kandaki normal seviyelerinin sağlanması için doğru bilgi sahibi
olmak çeşitli hastalıklardan ve kanserden korunmak açısından önemlidir. Bu
nedenle öncelikle D vitaminin sentezi, kandaki düzeyleri, günlük ihtiyaç,  metabolizması ve reseptörlerin durumu
derlendi.  Buna ek olarak D vitamininin
iyi bilinen kemik mineralizasyonu dışındaki etkilerinden olan özellikle kanser
gelişimi ile olan ilişkisine dair güncel bilgiler derlendi.

Anahtar Kelimeler

D vitamini, Sekosteroit, Kanser

As a secosteroid hormone Vitamin D and cancer

Öz

In addition to its well known classical effect on
calcium and phosphate metabolism Vitamin D which is actually a secosteroid
hormone also has antiproliferative and immunomodulatory properties. Recent
studies have shown that vitamin D deficiency may increase autoimmune and
cardiovascular diseases as well as cancer risk. Vitamin D deficiency has been
reported as a global epidemic in the world. In addition it has been identified
as a risk factor for osteoporosis and fall fractures. The right information to
ensure normal levels of vitamin D taken from the diet and synthesized by the
sunlight is important for protecting against various diseases and cancer.
Firstly, the synthesis, blood levels, the daily need, the metabolism and the
status of the receptors of vitamin D have been presented. In addition, current information
on the association of vitamin D with cancer developments that those outside the
well-known bone mineralization, were particularly presented.

Anahtar Kelimeler

Vitamin D, Secosteroid, Cancer

Kaynakça

• 1. Mohr SB, at al. Is ultraviolet B irradiance inversely associated with incidence rates of endometrial cancer: an ecological study of 107 countries. Prev Med 2007, 45:327–31.2. Salazar-Martinez E, at al. Dietary factors and endometrial cancer risk. Results of a case-control study in Mexico. Int J Gynecol Cancer 2005;15:938–45.3. Thorne J, Campbell MJ. The vitamin D receptor in cancer. Proc Nutr Soc 2008;67:115–27.4. Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 2005;16:83–95.5. Kuittinen T, at al. Paclitaxel, Carboplatin and 1,25-D3 Inhibit Proliferation of Endometrial Cancer Cells In Vitro. Anticancer Research 37: 6575-6581 (2017).6. Lungchukiet P, at al. Suppression of epithelial ovarian cancer invasion into the omentum by 1α,25-dihydroxyvitamin D3 and its receptor. J Steroid Biochem Mol Biol. 2015 April; 148: 138–147.7. Buggio L, at al. Vitamin D and benign gynaecological diseases: a critical analysis of the current evidence. Gynecol Endocrinol, 2016; 32(4): 259–263.8 .Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266–81.9. Whayne TF. Vitamin D. Popular Cardiovascular Supplement But Benefit Must Be Evaluated. International Journal of Angiology, 2011;20:63-71.10. Gültekin M, Hacikamiloğlu E. D Vitamini Güneş Işınları, UVB ve Kanser. Erişim: (http:kanser.gov.trbilgi-dokumanlarraporlar801-d-vitamini-g%C3%BCne%C5%9F-i%C5%9F%C4%B1nlar%C4%B1,-uvb-ve-kanser.html).11. Urbschat A, at al. Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma. Eur J Clin Invest. 2013 Dec;43(12):1282-90.12. Nemere I, Carson F. Membrane receptors for steroid hormones: a case for spesific cell surface binding sites for vitamin D metabolites and estrogens. Biochem Biophys Res Com 1998; 248:442-9.13.Norman AW. Receptors for 1,25(OH)2D3: past, present and future. J Bone Miner Res 1998;13:1360-9.14. De Luca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J 2001; 15:2579-85.15. Deuster E, at al. Vitamin D and VDR in Gynecological Cancers. A Systematic Review. Int. J. Mol. Sci. 2017, 18, 2328.16. What is Endometrial Cancer, American Cancer Society. Erişim: (https://www.cancer.org/cancer/endometrial-cancer/about/what-is-endometrial-cancer.html).17. Horner MJ, at al. Erişim: (https://seer.cancer.gov/archive/csr/1975_2006/). 18. Endometrial Cancer Risk Factors, American Cancer Society. Erişim: (https://www.cancer.org/cancer/endometrial-cancer/causes-risks-prevention/risk-factors.html).19. Fidan F, Alkan BM, Tosun A. Çağın Pandemisi: D Vitamini Eksikliği ve Yetersizliği. Türk Osteoporoz Dergisi 2014;20: 71-4.20. Sharan C, at al. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertil Steril 2011;95:247–53.21. Liu JJ, at al. Prospective analysis of vitamin D and endometrial cancer risk. Annals of Oncology 24: 687–692, 2013.22. Hossein-Nezhad A., Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc 2013;88:720–55.23. Garland CF, at al. The role of vitamin D in cancer prevention. Am J Public Health 2006; 96: 252–261.24. Garland CF, at al. Vitamin D for cancer prevention: global perspective. Ann Epidemiol 2009; 19: 468–483.25. Heath KM, Elovic EP. Vitamin D Deficiency: Implications in the Rehabilitation Setting. Am J PhysMedRehabil, 2006;85:916-923.26. Holick MF. Vitamin D Deficiency Medical Progress. N Engl J Med 2007;357:266-8127. Holick MF. High Prevalence of Vitamin D Inadequacy and Implications for Health. Mayo ClinProc. 2006;81:353-373.28. Gökalp Özkorkmaz E. Vitamin D ve Biyolojik Önemi.Biyoloji BilimLeri Araştırma Dergisi 2 (2): 11-15, 2009.29. Vitamin-D-metabolism. Erişim: (https://gettingstronger.org/2012/11/why-i-dont-take-vitamin-d-supplements/vitamin-d-metabolism/).30. Zempleni J, at al. Handbook of vitamins. 4th ed. CRC Press. New York. 608 p.31. Vitamin D metabolic pathways. Erişim: (https://www.researchgate.net/figure/Vitamin-D-metabolism-pathway-Proteins-with-genetic-polymorphisms-associated-with-vitamin_264631440). 32. Bikle D. Vitamin D Metabolism, Mechanism of Action, and Clinical Applications. Chem Biol. 2014 March 20; 21(3): 319–329.33. Posner GH, at al. Vitamin D analogues targeting CYP24 in chronic kidney disease. J. Steroid Biochem. Mol. Biol. 2010; 121:13–19.34. Öngen B, Kabaroğlu C, Parıldar Z. D Vitamini’nin Biyokimyasal ve Laboratuvar Değerlendirmesi. Ege Üniversitesi Tıp Fakültesi, Türk Klinik Biyokimya Dergisi 2008; 6: 23-31.35. Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys 2012;523:123-133.36. Wang TJ, at al. Vitamin D Deficiency and Risk of Cardiovascular Disease, Circulation. 2008;117:503-51137. Lee JH, at al. Vitamin D Deficiency- An Important,Common, and Easily Treatable Cardiovascular Risk Factor? J Am Coll Cardiol. 2008; 52:1949-5638. Contribution Of vitamin D To Good Health. Erişim: (https://www.vitamindwiki.com/tiki-download_wiki_attachment.php?attId=435). 39. Vitamin D: A Rapid Review. Erişim: (https://www.medscape.com/viewarticle/589256_8). 40. International Meeting of Vitamin D Scientists Reveals Most Not Getting Enough to Maintain Health. Erişim: (http://newsroom.ucr.edu/1321).41. Kıldır V. D Vitamininin kardiyovasküler ve metabolik etkileri. Journal of Clinical and Experimental Investigations. 2013; 4 (3): 398-40442. Cashman KD, at al. Vitamin D deficiency in Europe: pandemic?. Am J Clin Nutr 2016;103:1033–44.43. Erişim: (http://aa.com.tr/tr/saglik/turkiyede-d-vitamini-eksikligi-var/669650).44. Satman İ, at al. Prevalence of Vitamin D Deficiency and Associated Factors in Turkey. The Endocrine Society. J Clin Endocrinol Metab 2011; 96:1911.45. Erişim: (https://www.researchgate.net/publication/303404228_OSTEOPOROZ_ve_METABOLIK_KEMIK_HASTALIKLARI_TANI_ve_TEDAVI_KILAVUZU).46. Lavie CJ, Lee JH, Milani RV. Vitamin D and Cardiovascular Disease Will It Live Up to its Hype? Journal of theAmerican College of Cardiology, 2011; 58:1547-56.47. Wacker M, Holick MF. Vitamin D-Effects on Skeletal and Extraskeletal Health and the Need for Supplementation. Nutrients 2013;5:111-48.48. Apperly FL. The relation of solar radiation to cancer mortality in North American. Cancer Res 1941;1;191-19549. Garland FC. (1980). Do sunlight and vitamin D reduce the likelihood of colon cancer? İnt J epidemiol 1980;9:227-23150. Larsen ER, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents:a pragmatic population-based 3-year intervention study. J Bone Miner Res 2004; 19: 370.51. Ahonen MH, at al. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 2000;11:847–52.52. Bertone-Johnson ER, at al. Plasma 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2005;14:1991–7.53. Garland CF, at al. Serum 25-hydroxyvitamin D and colon cancer: eightyear prospective study. Lancet 1989;2:1176–8.54. Garland CF, at al. Vitamin D for cancer prevention: global perspective. Ann Epidemiol 2009;19:468–83.55. Lappe JM, at al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007;85:1586–91.56. Burgi AA, at al. High serum 25-hydroxyvitamin D is associated with a low incidence of stress fractures. J Bone Miner Res 2011;26:2371–7.57. Sözen T. D Hormonu: Güncel Gelişmeler, Hacettepe Tıp Dergisi 2011; 42:14-2758. Wu K, at al. A nested case control study of plasma 25 hydroxyvitamin D concentrations an risk of colorectal cancer. J Natl Cancer Ins 2007; 99:1120-9.59. Jenab M, at al. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study. BMJ. 2010 Jan 21;340:b5500. 60.Sofi NY, at al. Reproductive factors, nutritional status and serum 25(OH)D levels in women with breast cancer: A case control study. J Steroid Biochem Mol Biol. 2018 Jan;175:200-204.61. Bauer SR, at al. Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Medicine. 2013 May;92(3):123-31. 62.Chlebowski RT, at al. Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst. 2008 Nov 19;100(22):1581-91.
• 63. Arem H, at al. Vitamin D metabolic pathway genes and pancreatic cancer risk. PLoS One. 2015 Mar 23;10(3):e0117574.
• 64.Barreto SG, Neale RE. Vitamin D and pancreatic cancer. Cancer Lett. 2015 Nov 1;368(1):1-6.65.Huang JD, at al. Circulating 25-hydroxyvitamin D level and prognosis of lung cancer patients: A systematic reviewand meta-analysis. Bull Cancer. 2017 Jul - Aug;104(7-8):675-682.66.Pandolfi F, at al. Immune Modulation by Vitamin D: Special Emphasis on Its Role in Prevention and Treatment of Cancer. Clin Ther. 2017 May;39(5):884-893.