Sekosteroit hormon olarak D vitamini ve kanser ilişkisi

Öz

Klasik olarak kalsiyum ve fosfat mekanizması üzerine olan etkilerinin yanı sıra antiproliferatif ve immünomodülatör gibi özellikleri de olan D vitamini aslında bir seko-steroid hormondur. Yakın dönem çalışmalar, D vitamini eksikliğinin otoimmün ve kardiyovasküler hastalıkların yanı sıra kanser riskini artırabildiğini göstermiştir. D vitamini eksikliği dünyada küresel bir salgın olarak bildirilmiştir. Buna ek olarak osteoporoz ve düşme kırıkları için de bir risk faktörü olarak tanımlanmıştır. Diyetle alınan ve deride güneş aracılığı ile sentezlenen D vitamininin kandaki normal seviyelerinin sağlanması için doğru bilgi sahibi olmak çeşitli hastalıklardan ve kanserden korunmak açısından önemlidir. Bu nedenle öncelikle D vitaminin sentezi, kandaki düzeyleri, günlük ihtiyaç,  metabolizması ve reseptörlerin durumu derlendi.  Buna ek olarak D vitamininin iyi bilinen kemik mineralizasyonu dışındaki etkilerinden olan özellikle kanser gelişimi ile olan ilişkisine dair güncel bilgiler derlendi.

Anahtar Kelimeler

• D vitamini,Sekosteroit,Kanser

As a secosteroid hormone Vitamin D and cancer

Öz

In addition to its well known classical effect on calcium and phosphate metabolism Vitamin D which is actually a secosteroid hormone also has antiproliferative and immunomodulatory properties. Recent studies have shown that vitamin D deficiency may increase autoimmune and cardiovascular diseases as well as cancer risk. Vitamin D deficiency has been reported as a global epidemic in the world. In addition it has been identified as a risk factor for osteoporosis and fall fractures. The right information to ensure normal levels of vitamin D taken from the diet and synthesized by the sunlight is important for protecting against various diseases and cancer. Firstly, the synthesis, blood levels, the daily need, the metabolism and the status of the receptors of vitamin D have been presented. In addition, current information on the association of vitamin D with cancer developments that those outside the well-known bone mineralization, were particularly presented.

Anahtar Kelimeler

• Vitamin D,Secosteroid,Cancer

Kaynakça

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