Sekosteroit hormon olarak D vitamini ve kanser ilişkisi

Yıl 2019, Cilt: 9 Sayı: 1, 19 - 29, 28.01.2019

İbrahim Duman İsmail Ün

https://doi.org/10.31020/mutftd.456806

Cited By: 1

Öz

Klasik olarak kalsiyum
ve fosfat mekanizması üzerine olan etkilerinin yanı sıra antiproliferatif ve
immünomodülatör gibi özellikleri de olan D vitamini aslında bir seko-steroid
hormondur. Yakın dönem çalışmalar, D vitamini eksikliğinin otoimmün ve kardiyovasküler
hastalıkların yanı sıra kanser riskini artırabildiğini göstermiştir. D vitamini
eksikliği dünyada küresel bir salgın olarak bildirilmiştir. Buna ek olarak
osteoporoz ve düşme kırıkları için de bir risk faktörü olarak tanımlanmıştır. Diyetle alınan ve deride güneş aracılığı ile sentezlenen
D vitamininin kandaki normal seviyelerinin sağlanması için doğru bilgi sahibi
olmak çeşitli hastalıklardan ve kanserden korunmak açısından önemlidir. Bu
nedenle öncelikle D vitaminin sentezi, kandaki düzeyleri, günlük ihtiyaç,  metabolizması ve reseptörlerin durumu
derlendi.  Buna ek olarak D vitamininin
iyi bilinen kemik mineralizasyonu dışındaki etkilerinden olan özellikle kanser
gelişimi ile olan ilişkisine dair güncel bilgiler derlendi.

Anahtar Kelimeler

D vitamini, Sekosteroit, Kanser

As a secosteroid hormone Vitamin D and cancer

Öz

In addition to its well known classical effect on
calcium and phosphate metabolism Vitamin D which is actually a secosteroid
hormone also has antiproliferative and immunomodulatory properties. Recent
studies have shown that vitamin D deficiency may increase autoimmune and
cardiovascular diseases as well as cancer risk. Vitamin D deficiency has been
reported as a global epidemic in the world. In addition it has been identified
as a risk factor for osteoporosis and fall fractures. The right information to
ensure normal levels of vitamin D taken from the diet and synthesized by the
sunlight is important for protecting against various diseases and cancer.
Firstly, the synthesis, blood levels, the daily need, the metabolism and the
status of the receptors of vitamin D have been presented. In addition, current information
on the association of vitamin D with cancer developments that those outside the
well-known bone mineralization, were particularly presented.

Anahtar Kelimeler

Vitamin D, Secosteroid, Cancer

Kaynakça

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