Menopozal Semptom Yönetiminde Sarı Kantaron Kullanımı: Sistematik Derleme

Yıl 2020, Cilt: 10 Sayı: 2, 258 - 268, 22.05.2020

Tuğba Dündar , Belma Toptaş , Zekiye Karaçam

https://doi.org/10.31020/mutftd.688744

Cited By: 2

Öz

Amaç: Bu araştırma, menopoz döneminde kullanılan
sarı kantaron bitkisinin menopozal semptomlara etkisini incelemek amacı ile
yapılmıştır.

Yöntem: Sistematik derleme niteliğinde olan çalışma, 17
Aralık 2018-3 Ocak 2019 tarihleri arasında, Türkçe ve İngilizce dizinler taranarak
yapılmıştır. Ulakbim, Türk Medline, Google Akademik ve Ulusal Tez Merkezi Web of Science, PubMed (including MEDLINE),
Cochrane ve EBSCOhost veri tabanları, “menopoz, klimakteriyum, sarı
kantaron, St John’s wort, Hypericum perforatum, menopoz ve sarı kantaron,  menopoz ve St John’s wort, menopoz ve
Hypericum perforatum, klimakteriyum ve sarı kantaron, klimakteriyum ve St
John’s wort, klimakteriyum ve Hypericum perforatum” anahtar kelimeleri ile taranmıştır.

Bulgular: Çalışmada
toplam 602 kayda ulaşılmış olup, üçü sarı kantaronun tek başına, dördü farklı
bitkilerle bir arada kullanımının menopozal semptomlara etkisini inceleyen,
toplam 819 kadın ile yapılan dokuz araştırma analize alınmıştır. Sarı
kantaronun tek başına kullanıldığı beş çalışmadan ikisinde, bu bitkinin
vazomotor semptomları, ikisinde uyku sorunlarını, depresyon ve yorgunluğu
azaltmada etkili olduğu bildirilmiştir. Bitkinin kombine kullanıldığı dört
çalışmadan üçünde kombinasyonun vazomotor semptomları, ikisinde anksiyete ve
depresyonu azaltmada etkili olduğu, birinde ise vajinal kuruluk ve libido kaybı
üzerinde herhangi bir etkisinin olmadığı bildirilmiştir.

Sonuç: Bu
sistematik derlemede sarı kantaronun tek başına ya da kombine kullanımının
bazı menopozal semptomları azaltmada etkili olduğu, ancak bu konuda daha fazla
deneysel çalışmaya gereksinim bulunduğu sonucuna varılmıştır.

Anahtar Kelimeler: sarı kantaron (hypericum), , tamamlayıcı tedaviler

Anahtar Kelimeler

sarı kantaron (hypericum), menopoz, tamamlayıcı tedaviler

Destekleyen Kurum

buunmamaktadır.

Proje Numarası

proje değildir.

The Use Of St. John’s Wort In Menopausal Symptom Management: A Systematic Review

Öz

Aim: The study aimed to investigate the effect of St.
John’s wort on menopausal symptoms.

Method: This study is a systematic review and was conducted
between 17 December 2018-3 January 2019 by searching Turkish and English
indexes. Ulakbim, Turk Medline, Google Academic and National Thesis Centre, Web
of Science, PubMed (including MEDLINE), Cochrane and EBSCOhost database were
searched by using “Menopause,
climacterium, St. John's wort, Hypericum perforatum, menopause and St. John's wort,
menopause and St John’s wort, menopause and Hypericum perforatum, climacterium
and St. John's wort, climacterium and Hypericum perforatum”as keywords.  

Results: In this research, a total of 602 records were reached,
and seven researches were analysed with 819 women, three of which examined the
effect of the use of the St. John’s wort singly and four in combination with
different herbs on menopausal symptoms. In two of the three studies using the
St. John’s wort singly, this plant has been reported to be effective in
reducing vasomotor symptoms, sleeping problems, depression/fatigue in two. In
three of four studies used in combination of plant, was reported to be
effective in reducing vasomotor symptoms, both anxiety and depression in two,
and in one, it had no effect on vaginal dryness and loss of libido.

Conclusion: In this systematic review, it has been concluded that
the use of St. John's wort singly or in combination is effective in reducing
some menopausal symptoms, but further experimental studies are needed.

Anahtar Kelimeler

hypericum, menopause, complementary therapies

Proje Numarası

proje değildir.

Kaynakça

• 1. Lamberts SWJ, Beld AW. Endocrinology and aging. In: Melmed S, Auchus RJ, Goldfie AB, Koening RJ, Rosen CJ. editors. Williams textbook of endocrinology. Elseiver; 2016. pp:1234–1251.
• 2. Şen E, Sevil Ü. Menopoz semptomlarında tamamlayıcı tedaviler. İstanbul Üniversitesi Florence Nightingale Hemşirelik Derg 2008;16(62):136–42.
• 3. Rajput V. Menopause and alternative therapy. Asian J. Nurs. Edu. Res 2012;2(3):158–60.
• 4. Taylor M. Complementary and alternative approaches to menopause. Endocrinol. Metab. Clin. North Am 2015;44(3):619–48.
• 5. National Center for Complementary and Integrative Health [Internet]. Complementary, Alternative, or Integrative Health: What’s In a Name? (2018). [cited 2019 February 12] Available from: https://nccih.nih.gov/health/integrative-health.
• 6. Vukovic L. Basic health publications user’s guide to st john’s wort. 1st ed. Rosenberg C editor. North Bergen: Basic Health Pubilications; 2002.
• 7. Murray PB, Bongiorno MT. Hypericum perforatum (St. John’s Wort). In: Pizzorno JE, Murray MT, editors. Textbook of natural medicine. Churchill Livingstone; 2013. pp: 838–841.
• 8. Al-Akoum M, et al. Effects of hypericum perforatum (st. john’s wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause 2009;16(2):307–14.
• 9. Fahami F, et al. A comparative study on the effects of hypericum perforatum and passion flower on the menopausal symptoms of women referring to Isfahan city health care centers. Iran J Nurs Midwifery Res 2010;15(4):202–7.
• 10. van Die M, et al. Effects of a combination of hypericum perforatum and vitex agnus-castus on pms-like symptoms in late-perimenopausal women: findings from a subpopulation analysis. J. Altern. Complement. Med 2009;15(9):1045-8.
• 11. Laakmann E, et al. Efficacy of cimicifuga_racemosa,_hypericum_perforatum and agnus_castus in the treatment of climacteric complaints: a systematic review. Gynecol. Endocrinol 2012;28(9):703–9.
• 12. Abdali K, Khajehei M, Tabatabaee H. Effect of st john’s wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study. Menopause 2010;17(2):326–31.
• 13. Ghazanfarpour M, et al. Comparison the efficacy of hypericum perforatum and vitex agnus- castus in hot flushes : A double-blinded randomized controlled trial. Chronic Diseases Journal 2013;1(2):67–73.
• 14. Ghazanfarpour M, et al. Effects of flaxseed and hypericum perforatum on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women: a systematic review and meta-analysis. Avicenna J. phytomedicine 2016;6(3):273–83.
• 15. Liu Y, et al. Hypericum perforatum L. preparations for menopause: a meta-analysis of efficacy and safety. Climacteric 2014;17:325–35. 16. Karaçam Z. Sistematik derleme metodolojisi: sistematik derleme hazırlamak için bir rehber. Dokuz Eylül Üniversitesi Hemşirelik Yüksekokulu Elektron. Derg 2013;6(1): 26–33. 17. Moher D, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. PLOS Med 2009;6:1–5.
• 18. Joanna Briggs Institute[Internet]. Critical Appraisal Tools. (2018). [cited by 18.03.2019] Available from: http://joannabriggs.org/research/critical-appraisal-tools.html
• 19. Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. Explanation for the critical appraisal tool for RCTs with individual participants in parallel groups. In: Aromataris E, Munn Z, editors. Joanna Briggs Institute Reviewer's Manual. The Joanna Briggs Institute. 2017a. pp:1-9.
• 20. Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. Explanation for the critical appraisal tool for Quasi-Experimental Studies (experimental studies without random allocation). In: Aromataris E, Munn Z, editors. Joanna Briggs Institute Reviewer's Manual. The Joanna Briggs Institute. 2017b.pp:1-7.
• 21. Snilstveit B, Oliver S, Vojtkova, M. Narrative approaches to systematic review and synthesis of evidence for international development policy and practice. Journal of Development Effectiveness 2012;4(3):409–429.
• 22. Ryan R, Cochrane Consumers and Communication Review Group. Cochrane consumers and communication review group: data synthesis and analysis. Cochrane Consum. Commun. Rev. Gr. 2013;1–5.
• 23. Eatemadnia A, Ansari S, Abedi P, Najar S. The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial. Complement. Ther. Med 2019;45:109–113.
• 24. Chung D, et al. Black cohosh and st. john’s wort (GYNO-Plus®) for climacteric symptoms. Yonsei Med. J 2007;48(2):289–94.
• 25. Uebelhack R, et al. Black cohosh and st. john’s wort for climacteric complaints: a randomized trial. Obstet. Gynecol 2006;107(2):247–55.
• 26. van Die M, et al. Hypericum perforatum with vitex agnus-castus in menopausal symptoms: a randomized, controlled trial. Menopause 2009;16(1):156–63.
• 27. Mehrpooya M, et al. A comparative study on the effect of “black cohosh” and “evening primrose oil” on menopausal hot flashes. J Educ Health Promot 2018;7(36).
• 28. Newton KM, et al. Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet. Gynecol 2002;100(1):18–25.
• 29. Franco O, et al. Use of plant-based therapies and menopausal symptoms a systematic review and meta-analysis. Jama 2019;315(23):2554–63.
• 30. Timur S, Şahin NH. Menopoz ve uyku. Maltepe Üniversitesi Hemşirelik Bilim ve Sanatı Derg 2010;3(3):61–67.
• 31. Ulusoy MN, Kukulu K. Kadınlarda uyku sorunlarının menopoz ile ilişkisi. Gümüşhane Üniversitesi Sağlık Bilim Derg 2013;2(2):206–13.
• 32. Sharpley AL, et al. Antidepressant-like effect of hypericum perforatum (st john’s wort) on the sleep polysomnogram. Psychopharmacology (Berl) 1998;139(3):286–7.
• 33. Apaydin EA et al. A systematic review of st. john’s wort for major depressive disorder. Syst Rev 2016;5(1):148.
• 34. Ng QX, Venkatanarayanan N, Ho CYX. Clinical use of hypericum perforatum (st john’s wort) in depression: a meta-analysis. J Affect Disord 2017;210(January):211–21.
• 35. Wuttke W, Seidlová-wuttke D. Black cohosh ( cimicifuga racemosa ) is a non-estrogenic alternative to hormone replacement therapy. Clin. Phytoscience 2015;1(1):12.
• 36. Niroumand M, Heydarpour F, Farzaei M. Pharmacological and therapeutic effects of vitex agnus castus: a review. Pharmacogn Rev 2018;12(23):103–14.
• 37. Whiskey E, Werneke U, Taylor D. A systematic review and meta-analysis of hypericum perforatum in depression: A comprehensive clinical review. Int Clin Psychopharmacol 2001; 16(5):239–52.
• 38. Russo E, et al. Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions. Phyther Res 2014;28(5):643–55.