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Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi

Yıl 2021, Cilt: 11 Sayı: 3, 492 - 501, 22.09.2021
https://doi.org/10.31020/mutftd.916536

Öz

Amaç: Kişniş (Coriandrum sativum L.) meyveleri gıda olarak ve tıbbi amaçlarla kullanılmaktadır. Piyasada satılan ve tıbbi amaçlarla kullanılan kişniş meyvelerinin kalite kriterleri hakkında bir bilgi mevcut değildir. Bu sebeple, özellikle karminatif, antispazmotik ve iştah arttırıcı özellikleri sebebiyle sıklıkla kullanılan ve 12 farklı aktardan satın alınan kişniş örneklerinin kalite kontrolleri Avrupa Farmakopesi 8.0 standartlarına göre araştırılmıştır.
Yöntem: Kişniş numunelerinin standartlara uygunluğunu belirlemek için Avrupa Farmakopesi 8.0’da yer alan “Coriandri fructus’’ monografı kullanılmıştır. Örnekler, monografta belirlenen tüm analizler (morfolojik, mikroskobik, ince tabaka kromatografisi, yabancı madde, total kül, kurutmada kayıp ve uçucu yağ miktar tayini analizleri) için değerlendirilmiştir.
Bulgular: Bütün numunelerin morfolojik, mikroskobik, kurutmada kayıp, ince tabaka kromatografisi ve total kül miktarı analiz sonuçlarının Farmakopeye uygunluk gösterdiği, bir kısım numunenin yabancı madde ve uçucu yağ miktar tayini sonuçlarının Farmakope standartlarına uygunluk göstermediği tespit edilmiştir.
Sonuç: Analiz sonuçlarına göre incelenen 12 numunenin Avrupa Farmakopesi 8.0 standartlarına uygun olmadığı tespit edilmiştir. Bu çalışma ile bu tip bitkisel ürünlerin tıbbi amaçlarla ve fitoterapide kullanılmasının halk sağlığı açısından uygun olmadığı ve bu ürünlerin kalite kontrol analizleri yapıldıktan sonra eczanelerde satılmasının önemi bir kez daha ortaya çıkmıştır.

Kaynakça

  • 1. Sahib NG, et al. Coriander (Coriandrum sativum L.): A potential source of high-value components for functional foods and nutraceuticals-a review. Phytother Res 2013;27(10):1439-1456.
  • 2. Diederichsen A. Coriander (Coriandrum sativum L.) promoting the conservation and use of underutilized and neglected crops. Institute of Plant Genetics and Crop Plant Research, Gatersleben/International Plant Genetic Resources Institute, Rome;1996. pp:8-26.
  • 3. Tubives.com [Internet]: Coriandrum sativum, Turkish plants data service. [cited 2021 March 2]. Available from: http://www.tubives.com/
  • 4. Deniz EU, et al. Kişniş (Coriandrum sativum L.) üzerine bir derleme. Marmara Pharm J 2018;22(1): 15-28.
  • 5. Tanker N, Koyuncu M, Coşkun M. Farmasötik Botanik. 5.baskı. Ankara: Ankara Üniversitesi Basımevi; 2016. pp:251-252.
  • 6. Sriti J, et al. Lipid, fatty acid and tocol distribution of coriander fruit's different parts. Ind Crop Prod 2010;31(2):294-300.
  • 7. Laribi B, et al. Coriander (Coriandrum sativum L.) and its bioactive constituents. Fitoterapia 2015;103:9-26.
  • 8. Wei JN, et al. Phytochemical and bioactive profile of Coriandrum sativum L. Food Chem 2019; 286:260-267.
  • 9. Mahdi OS. Evaluation of inhibitory activity of extracts of Apium gravelens, Coriandrum sativum and Cuminum cyminum against number of pathogenic bacteria. Kufa J Vet Sci 2011;2(2):37-50.
  • 10. Casetti F, et al. Antimicrobial activity against bacteria with dermatological relevance and skin tolerance of the essential oil from Coriandrum sativum L. fruits. Phytother Res 2012;26(3):420-424.
  • 11. Soares BV, et al. Antifungal activity, toxicity and chemical composition of the essential oil of Coriandrum sativum L. fruits. Molecules 2012;17(7):8439-8448.
  • 12. Zhang CR, et al. Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chem 2015:167:24-29.
  • 13. Eguale T, et al. In vitro and In vivo anthelmintic activity of crude extracts of Coriandrum sativum against Haemonchus contortus. J Ethnopharmacol 2007;110(3):428-433.
  • 14. Yepez B, et al. Producing antioxidant fractions from herbaceous matrices by supercritical fluid extraction. Fluid Ph Equilibria 2002;194-197:879-884.
  • 15. Wangensteen H, Samuelsen AB, Malterud KE. Antioxidant activity in extracts from coriander. Food Chem 2004;88(2):293-297.
  • 16. Msaada K, et al. Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arab J Chem 2017;10(2):3176-3183.
  • 17. Benelli G, et al. Larvicidal and repellent activity of the essential oil of Coriandrum sativum L. (Apiaceae) fruits against the filariasis vector Aedes albopictus skuse (Diptera: Culicidae). Parasitol Res 2013;112(3):1155-1161.
  • 18. Pathan AR, Kothawade KA, Logade MN. Anxiolytic and analgesic effect of seeds of Coriandrum sativum Linn. Int J Res Pharm Chem 2011;1(4): 1087-1099.
  • 19. Emamghoreishi M, Khasaki M, Aazam MF. Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze. J Ethnopharmacol 2005;96(3):365-370.
  • 20. Patel D, et al. Coriandrum sativum L. seed extract mitigates lipotoxicity in Raw 264.7 cells and prevents atherogenic changes in rats. Excli J 2013;12:313-334.
  • 21. Chithra V, Leelamma S. Coriandrum sativum- mechanism of hypoglycemic action. Food Chem 1999;67(3):229-231.
  • 22. Eidi M, Eidi A. Effect of Coriander (Coriandrum sativum L.) seed ethanol extract in experimental diabetes. Preedy VR, Watson RS, Patel VB editors. Nuts and seeds in health and disease prevention. Academic Press; 2011. pp:395-400.
  • 23. Aissaoui A, et al. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J Ethnopharmacol 2011;137(1):652-661.
  • 24. Naquvi KJ, Ali M, Ahamad AJ. Antidiabetic activity of aqueous extract of Coriandrum sativum L. fruits in streptozotocin-induced rats. Int J Pharm Pharm Sci 2012;4(1):239-240.
  • 25. Waheed A, et al. Clinical investigation of hypoglycemic effect of Coriandrum sativum in type-2 (NIDDM) diabetic patients. Pakistan J P 2006;23(1):7-11.
  • 26. Chithra V, Leelamma S. Coriandrum sativum- effect on lipid metabolism in 1,2-dimethyl hydrazine-induced colon cancer. J Ethnopharmacol 2000;71(3):457-463.
  • 27. Al-Mofleh IA, et al. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Environ Toxicol Pharmacol 2006;22(1):64-69.
  • 28. Anilakumar KR, Nagaraj NS, Santhanam K. Effect of coriander seeds on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Nutr Res 2001;21(11):1455-1462.
  • 29. Patel DK, et al. Cardioprotective effect of Coriandrum sativum L. on isoproterenol induced myocardial necrosis in rats. Food Chem Toxicol 2012;50(9):3120-3125.
  • 30. Council of Europe (EDQM). Coriander, Coriandri fructus. European Pharmacopoeia 8.0. 2013:1220-1221.
  • 31. Herbsetc.com [Internet]. The medicinal properties of coriander. [cited 2021 March 3]. Available from: https://www.herbsetc.com/content/PDF/Coriander_article_2017.pdf
  • 32. Bisset G. Coriandri fructus, herbal drugs and phytopharmaceuticals. A handbook for practice on a scientific basis. Stuttgart: CRC Press; 1994. pp:159-160.
  • 33. Platel K, Srinivasan K. Digestive stimulant action of spices: a myth or reality? Indian J Med Res 2004;119(5):167-179.
  • 34. Jabeen Q, et al. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J Ethnopharmacol 2009;122(1):123-130.
  • 35. Alves-Silva JM, et al. Chemical composition and in vitro antimicrobial, antifungal and antioxidant properties of essential oils obtained from some herbs widely used in Portugal. Food Control 2013;32(2):371-378.
  • 36. Matasyoh JC, et al. Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum. Food Chem 2009;113(2):526-529.
  • 37. Abascal K, Yarnell E. Cilantro—Culinary herb or miracle medicinal plant? Altern Complement Ther 2012;18(5):259-264.
  • 38. El-Ghorab A, Shibamoto T, Özcan MM. Chemical composition and antioxidant activities of buds and leaves of capers (Capparis ovata Desf. var. canescens) cultivated in Turkey. J Essent Oil Res 2007;19(1):72-77.
  • 39. Shahwar MK, et al. Characterization of coriander (Coriandrum sativum L.) seeds and leaves: volatile and non volatile extracts. Int J food prop 2012;15(4):736-747.
  • 40. Ramadan MF, Moersel JT. Screening of the antiradical action of vegetable oils. J Food Compos Anal 2006;19(8):838-842.

An Investigation of the Samples Sold as Coriander in the Market in Terms of the European Pharmacopoeia Criteria

Yıl 2021, Cilt: 11 Sayı: 3, 492 - 501, 22.09.2021
https://doi.org/10.31020/mutftd.916536

Öz

Aim: Coriander (Coriandrum sativum L.) fruits are used as food and for medicinal purposes. There is no information about the quality criteria of coriander fruits sold in the market and used for medicinal purposes. For this reason, quality controls of coriander samples, which are frequently used due to its carminative, antispasmotic and appetite enhancing properties and purchased from 12 different herbalists, have been investigated according to the European Pharmacopoeia 8.0 standards.
Method: "Coriandri fructus" monograph in European Pharmacopoeia 8.0 was used to determine the quality of the Coriander samples. Samples were evaluated for all analyzes (morphological, microscopic, thin layer chromatography, foreign matter, total ash, loss in drying and essential oil quantification analysis) identified in the monograph.
Results: Morphological, microscopic, loss in drying, thin layer chromatography and total ash analysis results of all samples were found to be in accordance with Pharmacopoeia, and foreign matter and essential oil quantification results of some samples did not comply with Pharmacopoeia standards.
Conclusion: According to the results of the analysis, it was determined that the 12 samples examined were not compliant with the European Pharmacopoeia 8.0 standards. With this study, it was once again revealed that the use of these types of herbal products for medicinal purposes and phytotherapy is not suitable for public health and the importance of selling these products in pharmacies after quality control analysis has been made.

Kaynakça

  • 1. Sahib NG, et al. Coriander (Coriandrum sativum L.): A potential source of high-value components for functional foods and nutraceuticals-a review. Phytother Res 2013;27(10):1439-1456.
  • 2. Diederichsen A. Coriander (Coriandrum sativum L.) promoting the conservation and use of underutilized and neglected crops. Institute of Plant Genetics and Crop Plant Research, Gatersleben/International Plant Genetic Resources Institute, Rome;1996. pp:8-26.
  • 3. Tubives.com [Internet]: Coriandrum sativum, Turkish plants data service. [cited 2021 March 2]. Available from: http://www.tubives.com/
  • 4. Deniz EU, et al. Kişniş (Coriandrum sativum L.) üzerine bir derleme. Marmara Pharm J 2018;22(1): 15-28.
  • 5. Tanker N, Koyuncu M, Coşkun M. Farmasötik Botanik. 5.baskı. Ankara: Ankara Üniversitesi Basımevi; 2016. pp:251-252.
  • 6. Sriti J, et al. Lipid, fatty acid and tocol distribution of coriander fruit's different parts. Ind Crop Prod 2010;31(2):294-300.
  • 7. Laribi B, et al. Coriander (Coriandrum sativum L.) and its bioactive constituents. Fitoterapia 2015;103:9-26.
  • 8. Wei JN, et al. Phytochemical and bioactive profile of Coriandrum sativum L. Food Chem 2019; 286:260-267.
  • 9. Mahdi OS. Evaluation of inhibitory activity of extracts of Apium gravelens, Coriandrum sativum and Cuminum cyminum against number of pathogenic bacteria. Kufa J Vet Sci 2011;2(2):37-50.
  • 10. Casetti F, et al. Antimicrobial activity against bacteria with dermatological relevance and skin tolerance of the essential oil from Coriandrum sativum L. fruits. Phytother Res 2012;26(3):420-424.
  • 11. Soares BV, et al. Antifungal activity, toxicity and chemical composition of the essential oil of Coriandrum sativum L. fruits. Molecules 2012;17(7):8439-8448.
  • 12. Zhang CR, et al. Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chem 2015:167:24-29.
  • 13. Eguale T, et al. In vitro and In vivo anthelmintic activity of crude extracts of Coriandrum sativum against Haemonchus contortus. J Ethnopharmacol 2007;110(3):428-433.
  • 14. Yepez B, et al. Producing antioxidant fractions from herbaceous matrices by supercritical fluid extraction. Fluid Ph Equilibria 2002;194-197:879-884.
  • 15. Wangensteen H, Samuelsen AB, Malterud KE. Antioxidant activity in extracts from coriander. Food Chem 2004;88(2):293-297.
  • 16. Msaada K, et al. Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit varieties. Arab J Chem 2017;10(2):3176-3183.
  • 17. Benelli G, et al. Larvicidal and repellent activity of the essential oil of Coriandrum sativum L. (Apiaceae) fruits against the filariasis vector Aedes albopictus skuse (Diptera: Culicidae). Parasitol Res 2013;112(3):1155-1161.
  • 18. Pathan AR, Kothawade KA, Logade MN. Anxiolytic and analgesic effect of seeds of Coriandrum sativum Linn. Int J Res Pharm Chem 2011;1(4): 1087-1099.
  • 19. Emamghoreishi M, Khasaki M, Aazam MF. Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze. J Ethnopharmacol 2005;96(3):365-370.
  • 20. Patel D, et al. Coriandrum sativum L. seed extract mitigates lipotoxicity in Raw 264.7 cells and prevents atherogenic changes in rats. Excli J 2013;12:313-334.
  • 21. Chithra V, Leelamma S. Coriandrum sativum- mechanism of hypoglycemic action. Food Chem 1999;67(3):229-231.
  • 22. Eidi M, Eidi A. Effect of Coriander (Coriandrum sativum L.) seed ethanol extract in experimental diabetes. Preedy VR, Watson RS, Patel VB editors. Nuts and seeds in health and disease prevention. Academic Press; 2011. pp:395-400.
  • 23. Aissaoui A, et al. Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. J Ethnopharmacol 2011;137(1):652-661.
  • 24. Naquvi KJ, Ali M, Ahamad AJ. Antidiabetic activity of aqueous extract of Coriandrum sativum L. fruits in streptozotocin-induced rats. Int J Pharm Pharm Sci 2012;4(1):239-240.
  • 25. Waheed A, et al. Clinical investigation of hypoglycemic effect of Coriandrum sativum in type-2 (NIDDM) diabetic patients. Pakistan J P 2006;23(1):7-11.
  • 26. Chithra V, Leelamma S. Coriandrum sativum- effect on lipid metabolism in 1,2-dimethyl hydrazine-induced colon cancer. J Ethnopharmacol 2000;71(3):457-463.
  • 27. Al-Mofleh IA, et al. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Environ Toxicol Pharmacol 2006;22(1):64-69.
  • 28. Anilakumar KR, Nagaraj NS, Santhanam K. Effect of coriander seeds on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Nutr Res 2001;21(11):1455-1462.
  • 29. Patel DK, et al. Cardioprotective effect of Coriandrum sativum L. on isoproterenol induced myocardial necrosis in rats. Food Chem Toxicol 2012;50(9):3120-3125.
  • 30. Council of Europe (EDQM). Coriander, Coriandri fructus. European Pharmacopoeia 8.0. 2013:1220-1221.
  • 31. Herbsetc.com [Internet]. The medicinal properties of coriander. [cited 2021 March 3]. Available from: https://www.herbsetc.com/content/PDF/Coriander_article_2017.pdf
  • 32. Bisset G. Coriandri fructus, herbal drugs and phytopharmaceuticals. A handbook for practice on a scientific basis. Stuttgart: CRC Press; 1994. pp:159-160.
  • 33. Platel K, Srinivasan K. Digestive stimulant action of spices: a myth or reality? Indian J Med Res 2004;119(5):167-179.
  • 34. Jabeen Q, et al. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J Ethnopharmacol 2009;122(1):123-130.
  • 35. Alves-Silva JM, et al. Chemical composition and in vitro antimicrobial, antifungal and antioxidant properties of essential oils obtained from some herbs widely used in Portugal. Food Control 2013;32(2):371-378.
  • 36. Matasyoh JC, et al. Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum. Food Chem 2009;113(2):526-529.
  • 37. Abascal K, Yarnell E. Cilantro—Culinary herb or miracle medicinal plant? Altern Complement Ther 2012;18(5):259-264.
  • 38. El-Ghorab A, Shibamoto T, Özcan MM. Chemical composition and antioxidant activities of buds and leaves of capers (Capparis ovata Desf. var. canescens) cultivated in Turkey. J Essent Oil Res 2007;19(1):72-77.
  • 39. Shahwar MK, et al. Characterization of coriander (Coriandrum sativum L.) seeds and leaves: volatile and non volatile extracts. Int J food prop 2012;15(4):736-747.
  • 40. Ramadan MF, Moersel JT. Screening of the antiradical action of vegetable oils. J Food Compos Anal 2006;19(8):838-842.
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Erek Ulutaş 0000-0002-2949-8100

Semih Bulut 0000-0002-4098-0221

Didem Deliorman Orhan 0000-0003-3916-4048

Yayımlanma Tarihi 22 Eylül 2021
Gönderilme Tarihi 15 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 11 Sayı: 3

Kaynak Göster

APA Ulutaş, E., Bulut, S., & Deliorman Orhan, D. (2021). Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, 11(3), 492-501. https://doi.org/10.31020/mutftd.916536
AMA Ulutaş E, Bulut S, Deliorman Orhan D. Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. Eylül 2021;11(3):492-501. doi:10.31020/mutftd.916536
Chicago Ulutaş, Erek, Semih Bulut, ve Didem Deliorman Orhan. “Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi 11, sy. 3 (Eylül 2021): 492-501. https://doi.org/10.31020/mutftd.916536.
EndNote Ulutaş E, Bulut S, Deliorman Orhan D (01 Eylül 2021) Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 11 3 492–501.
IEEE E. Ulutaş, S. Bulut, ve D. Deliorman Orhan, “Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi”, Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, c. 11, sy. 3, ss. 492–501, 2021, doi: 10.31020/mutftd.916536.
ISNAD Ulutaş, Erek vd. “Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 11/3 (Eylül 2021), 492-501. https://doi.org/10.31020/mutftd.916536.
JAMA Ulutaş E, Bulut S, Deliorman Orhan D. Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2021;11:492–501.
MLA Ulutaş, Erek vd. “Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, c. 11, sy. 3, 2021, ss. 492-01, doi:10.31020/mutftd.916536.
Vancouver Ulutaş E, Bulut S, Deliorman Orhan D. Piyasada Kişniş Olarak Satılan Örneklerin Avrupa Farmakopesi Kriterleri Yönünden İncelenmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2021;11(3):492-501.
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