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Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu

Yıl 2025, Cilt: 15 Sayı: 3, 799 - 807, 30.09.2025

Öz

Anesteziyolojinin gelişimi, modern tıbbın ve özellikle cerrahi disiplinlerin evriminde dönüm noktası niteliğindedir. Bu makalede, anestezinin tarihsel kökenlerinden başlayarak diş hekimliği ve oral maksillofasiyal cerrahideki uygulamalarına kadar uzanan süreç ele alınmıştır. Diş hekimliğinde anesteziyolojinin kökleri, önemli tıbbi keşiflerin ve ilerlemelerin yaşandığı bir dönem olan XIX. yüzyılın ortalarına kadar uzanmaktadır. Anesteziyolojinin gelişiminin merkezinde, öncü çalışmalarıyla dental prosedürlerde ağrı yönetiminin temelini atan iki diş hekimi, Horace Wells ve William T.G. Morton yer almaktadır. XIX. yüzyılda Horace Wells ve William T.G. Morton’un öncülüğünde geliştirilen anestezi teknikleri, dental uygulamalarda ağrı yönetimini mümkün kılmış; böylece hem hasta konforunu artırmış hem de daha karmaşık müdahalelere olanak tanımıştır. Lokal anesteziklerin keşfi, sedasyon yöntemlerinin entegrasyonu ve genel anestezinin çene cerrahisinde kullanımı, disiplinler arası iş birliği gerektiren yeni bir dönem başlatmıştır. Günümüzde teknolojik gelişmeler ve hasta merkezli yaklaşımlar sayesinde dental anesteziyoloji, hem güvenlik hem etkinlik açısından ileri düzeye ulaşmış; gelecekte ise bilgisayar destekli sistemler ve yeni farmakolojik ajanlarla daha da gelişeceği öngörülmektedir. Anestezinin diş hekimliğine entegrasyonu, bu alanda hem klinik pratiği hem de hasta deneyimini kökten değiştirmiştir.

Kaynakça

  • 1. Johnston D. Anaesthesia and the Practice of Medicine: Historical Perspectives. Ulster Med J 2008 May;77(2):142.
  • 2. Robinson DH, Toledo AH. Historical development of modern anesthesia. J Invest Surg 2012 Jun;25(3):141-9. doi: 10.3109/08941939.2012.690328.
  • 3. Kuhlen FJ. Historisches zum Thema Schmerz und Schmerztherapie: Zwischen „Strafe Gottes”︁ und „göttlichem Werk”︁. Pharmazie in unserer Zeit 31;2002. pp:13-22.
  • 4. Fülöp-Miller R, Paul E, Paul C. Triumph over pain [Internet]. Indianapolis, New York: Bobbs-Merrill Co. 1938. (cited 2025 May 14). 498 p. Available from: http://archive.org/details/triumphoverpain00fl
  • 5. Spielman AI. History of Dental Anesthesia. In: Illustrated Encyclopedia of the History of Dentistry. 2023. Available from: https://historyofdentistryandmedicine.com/
  • 6. Homer I. The iliad-homer-ancient Greece-classical literature[Internet] (cited 2025 May 29). Available from: http://www.ancient-literature.com/greece_homer_iliad.html
  • 7. Jocks IT. The compositiones medicamentorum of scribonius Largus [Internet] (MRes). University of Glasgow; 2013 (cited 2025 May 16). Available from: http://encore.lib.gla.ac.uk/iii/encore/record/C__Rb3009179
  • 8. Nathan J, Asadourian L, Erlich MA. A brief history of local anesthesia. Int J Head Neck Surg 2016;7(1):29-32. 9. Davison MH. The evolution of anaesthesia. Br J Anaesth 1959 Mar 1;31(3):134-137.
  • 10. Batiha GE, et al. Syzygium aromaticum L. (Myrtaceae): traditional uses, bioactive chemical constituents, pharmacological and toxicological activities. Biomolecules. 2020 Jan 30;10(2):202. doi: 10.3390/biom10020202.
  • 11. Cervino G. Milestones of Dentistry: Advent of Anesthetics in Oral Surgery. Dent J (Basel) 2019 Dec 10;7(4):112. doi: 10.3390/dj7040112.
  • 12. Shaffer H. Uber coca: Freud's cocaine discoveries. J Subst Abuse Treat 1984;1(3):205-17.
  • 13. Markel H. Über Coca: Sigmund Freud, Carl Koller, and Cocaine. JAMA 2011;305(13):1360–1361. doi:10.1001/jama.2011.394
  • 14. Ring ME. The history of local anesthesia. J Calif Dent Assoc 2007;35(4):275-82.
  • 15. Yagiela JA. Local Anesthetics: A Century of Progress. Anesth Prog. 2020 Dec 1;67(4):235-244. doi: 10.2344/0003-3006-67.4.235.
  • 16. Monica WS. The perilous development of safe local anestheisa. Dent Surv. 1976 Jun;52(6):30-32.
  • 17. Link W. Alfred Einhorn, Sc D: Inventor of novocaine. Dent Radiog Photog 1959;32(1):20.
  • 18. Calatayud J, González A. History of the development and evolution of local anesthesia since the coca leaf. Anesthesiology 2003 Jun;98(6):1503-8. doi: 10.1097/00000542-200306000-00031.
  • 19. Braun H: Ueber einige neue örtliche anaesthetica (Stovain, Alypin, Novocain).Dtsch Med Wochenschr 1905;31:1667–71
  • 20. Benedict HC, Clark SW, Freeman CW: Studies in local anesthesia. J Am Dent Assoc 1932;19:2087–105
  • 21. Klauder JV: Novocain dermatitis. Dent Cosmos 1922;64:305–9
  • 22. Löfgren N, Lundquist B: Studies on local anaesthetics: II. Svenks Kem Tidskr 1946;58:206–17
  • 23. Ekenstam B, Egner B, Pettersson G: Local anaesthetics: I. N-alkyl pyrrolidine and N-alkyl piperidine carboxylic acid amides. Acta Chem Scand 1957;11:1183–90
  • 24. Löfgren N, Tegner C: Studies on local anesthetics: XX. Synthesis of some -monoalkylamino-2.-methylpropionanilides: A new useful local anesthetic. Acta Chem Scand 1960;14:486–90
  • 25. Adams HJ, Kronberg GH, Takman BH. Local anesthetic activity and acute toxicity of ( ) 2-(N-Ethylpropylamino)-2', 6'-butyroxylidide, a new long-acting agent. J Pharm Sci 1972;61:1829–31
  • 26. Winther JE, Nathalang B. Effectivity of a new local analgesic Hoe 40 045. Scand J Dent Res 1972;80:272–8
  • 27. Tobe M, Suto T, Saito S. The history and progress of local anesthesia: multiple approaches to elongate the action. J Anesth 2018 Aug;32(4):632-636. doi: 10.1007/s00540-018-2514-8.
  • 28. Mistry LN, et al. Horace Wells: A Pioneer in Modern Anesthesia and Pain-Free Medical Practices. Cureus. 2024 Oct 15;16(10):e71575. doi: 10.7759/cureus.71575.
  • 29. Tanchyk AP. Horace Wells as a classic tragic hero. J Anesth Hist. 2021 Jun;7(2):27-31. doi: 10.1016/j.janh.2021.02.001.
  • 30. Fenster JM. Ether Day : The Strange Tale of America’s Greatest Medical Discovery and the Haunted Men Who Made It. 1st ed. New York: HarperCollins, 2001. Print.
  • 31. Wolfe RJ. Tarnished Idol: William Thomas Green Morton and the Introduction of Surgical Anaesthesia: A Chronicle of Ether Controversy. Norman Publishing; San Anselmo, California: 2001.
  • 32. Bennett M. Blessed days of anaesthesia: how anaesthetics changed the World – by Stephanie J. Snow. History 2009;95(318):100-1.
  • 33. Ruetsch YA, Böni T, Borgeat A. From cocaine to ropivacaine: the history of local anesthetic drugs. Curr Top Med Chem 2001 Aug;1(3):175-82. doi: 10.2174/1568026013395335.
  • 34. Laskin DM. Anesthesiology: where do we go from here? J Oral Maxillofac Surg. 1995 Jan;53(1):1. doi: 10.1016/0278-2391(95)90485-9.
  • 35. Peskin RM. Dentists and anesthesia: historical and contemporary perspectives. Anesth Prog 1993;40(1):1-13.
  • 36. Clark MS, Campbell SA, Clark AM. Technique for the administration of nitrous oxide/oxygen sedation to ensure psychotropic analgesic nitrous oxide (PAN) effects. Int J Neurosci 2006;116(7):871–877. doi: 10.1080/00207450600754012.
  • 37. Khinda V, Rao D, Sodhi SPS. Nitrous Oxide Inhalation Sedation Rapid Analgesia in Dentistry: An Overview of Technique, Objectives, Indications, Advantages, Monitoring, and Safety Profile. Int J Clin Pediatr Dent 2023 Jan-Feb;16(1):131-138. doi: 10.5005/jp-journals-10005-1807.
  • 38. Trieger N. Intravenous sedation in dentistry and oral surgery. Int Anesthesiol Clin 1989 Summer;27(2):83-91. doi: 10.1097/00004311-198902720-00004.
  • 39. Kapur A, Kapur V. Conscious Sedation in Dentistry. Ann Maxillofac Surg 2018 Jul-Dec;8(2):320-323. doi: 10.4103/ams.ams_191_18.
  • 40. Fiorillo L. Conscious Sedation in Dentistry. Medicina (Kaunas). 2019 Dec 7;55(12):778. doi: 10.3390/medicina55120778.
  • 41. Rigg JR, Harries JD. Future of anesthesia. Can J Surg 1977 Sep;20(5):467-70.
  • 42. Weaver JM. The History of the American Dental Board of Anesthesiology. Anesth Prog 2020 Jun 1;67(2):67-71. doi: 10.2344/anpr-67-02-13.
  • 43. The American Dental Board of Anesthesiology [Internet]. Chicago (IL): The American Dental Board of Anesthesiology; [cited 2025 July 25]. Available from: https://www.adba.org/eligibility/residency-programs

The Historical and Clinical Journey of Anesthesia in Dentistry

Yıl 2025, Cilt: 15 Sayı: 3, 799 - 807, 30.09.2025

Öz

The development of anesthesiology is a milestone in the evolution of modern medicine and especially surgical disciplines. In this article, the historical origins of anesthesia and its applications in dentistry and oral maxillofacial surgery are discussed. The roots of anesthesiology in dentistry date back to the mid-XIX century, a period of significant medical discoveries and advances. At the center of the development of anesthesiology were two dentists, Horace Wells and William T.G. Morton, whose pioneering work laid the foundation for pain management in dental procedures. In the XIX century, anesthesia techniques pioneered by Horace Wells and William T.G. Morton made pain management in dental procedures possible, thus improving patient comfort and enabling more complex interventions. The discovery of local anesthetics, the integration of sedation methods and the use of general anesthesia in maxillofacial surgery have ushered in a new era that requires interdisciplinary cooperation. Today, thanks to technological advances and patient-centered approaches, dental anesthesiology has reached an advanced level in terms of both safety and efficacy, and it is predicted that it will develop further in the future with computer-aided systems and new pharmacological agents. The integration of anesthesia into dentistry has radically changed both clinical practice and patient experience in this field.

Kaynakça

  • 1. Johnston D. Anaesthesia and the Practice of Medicine: Historical Perspectives. Ulster Med J 2008 May;77(2):142.
  • 2. Robinson DH, Toledo AH. Historical development of modern anesthesia. J Invest Surg 2012 Jun;25(3):141-9. doi: 10.3109/08941939.2012.690328.
  • 3. Kuhlen FJ. Historisches zum Thema Schmerz und Schmerztherapie: Zwischen „Strafe Gottes”︁ und „göttlichem Werk”︁. Pharmazie in unserer Zeit 31;2002. pp:13-22.
  • 4. Fülöp-Miller R, Paul E, Paul C. Triumph over pain [Internet]. Indianapolis, New York: Bobbs-Merrill Co. 1938. (cited 2025 May 14). 498 p. Available from: http://archive.org/details/triumphoverpain00fl
  • 5. Spielman AI. History of Dental Anesthesia. In: Illustrated Encyclopedia of the History of Dentistry. 2023. Available from: https://historyofdentistryandmedicine.com/
  • 6. Homer I. The iliad-homer-ancient Greece-classical literature[Internet] (cited 2025 May 29). Available from: http://www.ancient-literature.com/greece_homer_iliad.html
  • 7. Jocks IT. The compositiones medicamentorum of scribonius Largus [Internet] (MRes). University of Glasgow; 2013 (cited 2025 May 16). Available from: http://encore.lib.gla.ac.uk/iii/encore/record/C__Rb3009179
  • 8. Nathan J, Asadourian L, Erlich MA. A brief history of local anesthesia. Int J Head Neck Surg 2016;7(1):29-32. 9. Davison MH. The evolution of anaesthesia. Br J Anaesth 1959 Mar 1;31(3):134-137.
  • 10. Batiha GE, et al. Syzygium aromaticum L. (Myrtaceae): traditional uses, bioactive chemical constituents, pharmacological and toxicological activities. Biomolecules. 2020 Jan 30;10(2):202. doi: 10.3390/biom10020202.
  • 11. Cervino G. Milestones of Dentistry: Advent of Anesthetics in Oral Surgery. Dent J (Basel) 2019 Dec 10;7(4):112. doi: 10.3390/dj7040112.
  • 12. Shaffer H. Uber coca: Freud's cocaine discoveries. J Subst Abuse Treat 1984;1(3):205-17.
  • 13. Markel H. Über Coca: Sigmund Freud, Carl Koller, and Cocaine. JAMA 2011;305(13):1360–1361. doi:10.1001/jama.2011.394
  • 14. Ring ME. The history of local anesthesia. J Calif Dent Assoc 2007;35(4):275-82.
  • 15. Yagiela JA. Local Anesthetics: A Century of Progress. Anesth Prog. 2020 Dec 1;67(4):235-244. doi: 10.2344/0003-3006-67.4.235.
  • 16. Monica WS. The perilous development of safe local anestheisa. Dent Surv. 1976 Jun;52(6):30-32.
  • 17. Link W. Alfred Einhorn, Sc D: Inventor of novocaine. Dent Radiog Photog 1959;32(1):20.
  • 18. Calatayud J, González A. History of the development and evolution of local anesthesia since the coca leaf. Anesthesiology 2003 Jun;98(6):1503-8. doi: 10.1097/00000542-200306000-00031.
  • 19. Braun H: Ueber einige neue örtliche anaesthetica (Stovain, Alypin, Novocain).Dtsch Med Wochenschr 1905;31:1667–71
  • 20. Benedict HC, Clark SW, Freeman CW: Studies in local anesthesia. J Am Dent Assoc 1932;19:2087–105
  • 21. Klauder JV: Novocain dermatitis. Dent Cosmos 1922;64:305–9
  • 22. Löfgren N, Lundquist B: Studies on local anaesthetics: II. Svenks Kem Tidskr 1946;58:206–17
  • 23. Ekenstam B, Egner B, Pettersson G: Local anaesthetics: I. N-alkyl pyrrolidine and N-alkyl piperidine carboxylic acid amides. Acta Chem Scand 1957;11:1183–90
  • 24. Löfgren N, Tegner C: Studies on local anesthetics: XX. Synthesis of some -monoalkylamino-2.-methylpropionanilides: A new useful local anesthetic. Acta Chem Scand 1960;14:486–90
  • 25. Adams HJ, Kronberg GH, Takman BH. Local anesthetic activity and acute toxicity of ( ) 2-(N-Ethylpropylamino)-2', 6'-butyroxylidide, a new long-acting agent. J Pharm Sci 1972;61:1829–31
  • 26. Winther JE, Nathalang B. Effectivity of a new local analgesic Hoe 40 045. Scand J Dent Res 1972;80:272–8
  • 27. Tobe M, Suto T, Saito S. The history and progress of local anesthesia: multiple approaches to elongate the action. J Anesth 2018 Aug;32(4):632-636. doi: 10.1007/s00540-018-2514-8.
  • 28. Mistry LN, et al. Horace Wells: A Pioneer in Modern Anesthesia and Pain-Free Medical Practices. Cureus. 2024 Oct 15;16(10):e71575. doi: 10.7759/cureus.71575.
  • 29. Tanchyk AP. Horace Wells as a classic tragic hero. J Anesth Hist. 2021 Jun;7(2):27-31. doi: 10.1016/j.janh.2021.02.001.
  • 30. Fenster JM. Ether Day : The Strange Tale of America’s Greatest Medical Discovery and the Haunted Men Who Made It. 1st ed. New York: HarperCollins, 2001. Print.
  • 31. Wolfe RJ. Tarnished Idol: William Thomas Green Morton and the Introduction of Surgical Anaesthesia: A Chronicle of Ether Controversy. Norman Publishing; San Anselmo, California: 2001.
  • 32. Bennett M. Blessed days of anaesthesia: how anaesthetics changed the World – by Stephanie J. Snow. History 2009;95(318):100-1.
  • 33. Ruetsch YA, Böni T, Borgeat A. From cocaine to ropivacaine: the history of local anesthetic drugs. Curr Top Med Chem 2001 Aug;1(3):175-82. doi: 10.2174/1568026013395335.
  • 34. Laskin DM. Anesthesiology: where do we go from here? J Oral Maxillofac Surg. 1995 Jan;53(1):1. doi: 10.1016/0278-2391(95)90485-9.
  • 35. Peskin RM. Dentists and anesthesia: historical and contemporary perspectives. Anesth Prog 1993;40(1):1-13.
  • 36. Clark MS, Campbell SA, Clark AM. Technique for the administration of nitrous oxide/oxygen sedation to ensure psychotropic analgesic nitrous oxide (PAN) effects. Int J Neurosci 2006;116(7):871–877. doi: 10.1080/00207450600754012.
  • 37. Khinda V, Rao D, Sodhi SPS. Nitrous Oxide Inhalation Sedation Rapid Analgesia in Dentistry: An Overview of Technique, Objectives, Indications, Advantages, Monitoring, and Safety Profile. Int J Clin Pediatr Dent 2023 Jan-Feb;16(1):131-138. doi: 10.5005/jp-journals-10005-1807.
  • 38. Trieger N. Intravenous sedation in dentistry and oral surgery. Int Anesthesiol Clin 1989 Summer;27(2):83-91. doi: 10.1097/00004311-198902720-00004.
  • 39. Kapur A, Kapur V. Conscious Sedation in Dentistry. Ann Maxillofac Surg 2018 Jul-Dec;8(2):320-323. doi: 10.4103/ams.ams_191_18.
  • 40. Fiorillo L. Conscious Sedation in Dentistry. Medicina (Kaunas). 2019 Dec 7;55(12):778. doi: 10.3390/medicina55120778.
  • 41. Rigg JR, Harries JD. Future of anesthesia. Can J Surg 1977 Sep;20(5):467-70.
  • 42. Weaver JM. The History of the American Dental Board of Anesthesiology. Anesth Prog 2020 Jun 1;67(2):67-71. doi: 10.2344/anpr-67-02-13.
  • 43. The American Dental Board of Anesthesiology [Internet]. Chicago (IL): The American Dental Board of Anesthesiology; [cited 2025 July 25]. Available from: https://www.adba.org/eligibility/residency-programs
Toplam 42 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Derleme
Yazarlar

Oğuz Temizel 0009-0001-5162-621X

Gülsüm Ak 0000-0002-3339-1568

Erken Görünüm Tarihi 27 Eylül 2025
Yayımlanma Tarihi 30 Eylül 2025
Gönderilme Tarihi 10 Temmuz 2025
Kabul Tarihi 24 Eylül 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 15 Sayı: 3

Kaynak Göster

APA Temizel, O., & Ak, G. (2025). Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, 15(3), 799-807.
AMA Temizel O, Ak G. Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. Eylül 2025;15(3):799-807.
Chicago Temizel, Oğuz, ve Gülsüm Ak. “Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 15, sy. 3 (Eylül 2025): 799-807.
EndNote Temizel O, Ak G (01 Eylül 2025) Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 15 3 799–807.
IEEE O. Temizel ve G. Ak, “Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu”, Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, c. 15, sy. 3, ss. 799–807, 2025.
ISNAD Temizel, Oğuz - Ak, Gülsüm. “Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 15/3 (Eylül2025), 799-807.
JAMA Temizel O, Ak G. Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2025;15:799–807.
MLA Temizel, Oğuz ve Gülsüm Ak. “Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, c. 15, sy. 3, 2025, ss. 799-07.
Vancouver Temizel O, Ak G. Diş Hekimliğinde Anestezinin Tarihsel ve Klinik Yolculuğu. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2025;15(3):799-807.
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