Antifungal Activities of Copper (II) Ion and Histidine Incorporated Polymers on Yeast Saccharomyces cerevisiae
Öz
One of the most serious concerns in biomedical implant occlusion and deep wound healing is microbial infections caused by bacteria and fungi. Therefore, it is crucial to design materials with antimicrobial and antifungal properties to prevent or cure infections in the wound, its surroundings, and the site where the implant will be placed. Cryo-hydrogels, called cryogels, are a valuable option for wound healing materials. In this study, various polymers were synthesized using the cryopolymerization process in order to examine the changes in the antifungal effects of the materials when metal ion and amino acid are incorporated. Swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction investigations were performed to characterize the polymers synthesized using 2-hydroxyethyl methacrylate (HEMA) as main monomer. The antifungal actions of the cryogels were examined on the eukaryotic yeast cell model S. cerevisiae, also referred to as baker's yeast or brewer's yeast. HEMA-based polymers exhibit porous morphology. Results showed that copper ions play an essential role in the antifungal activity of the HEMA-based polymers while attachment of additional histidine causes the recovery of cell metabolic activity.
Anahtar Kelimeler
Kaynakça
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