Antioxidant activity and tyrosinase enzyme inhibition potential of the endemic Stachys gaziantepensis and Stachys ketenoglui (Lamiaceae) from Turkey
Öz
This study investigates the phytochemical profile and biological activities of two endemic Turkish species, Stachys gaziantepensis and Stachys ketenoglui. Aerial parts of the plants were extracted using ethyl acetate, methanol, and water through an ultrasound-assisted extraction process. The resulting extracts were evaluated in terms of total phenolic and flavonoid contents, antioxidant capacity (DPPH, ABTS, and metal chelation assays), and tyrosinase inhibitory activity.
Among the tested samples, the ethyl acetate extract of S. gaziantepensis exhibited the highest phenolic and flavonoid levels. Methanol extracts of both species demonstrated superior radical scavenging performance in DPPH and ABTS assays, whereas the strongest metal-chelating effect was observed in the ethyl acetate extract of S. ketenoglui. Notably, the ethyl acetate extract of S. gaziantepensis showed pronounced tyrosinase inhibition.
Overall, the findings indicate that both species possess considerable bioactive potential, with S. gaziantepensis displaying comparatively stronger activity. The results also emphasize the influence of solvent polarity on the extraction of biologically active compounds, suggesting that these endemic taxa may serve as promising candidates for pharmaceutical and cosmetic applications.
Anahtar Kelimeler
Antioxidant activity, Stachys gaziantepensis, Stachys ketenoglui, Tyrosinase enzyme inhibition
Destekleyen Kurum
Supported by Selçuk University Scientific Research Projects Coordination Office with Project Number 2201047
Proje Numarası
2201047
Teşekkür
Selçuk University Scientific Research Projects Coordination Office
Kaynakça
- Faydaoğlu, E., and Sürücüoğlu, M. S., (2011). “Geçmişten günümüze tıbbi ve aromatik bitkilerin kullanılması ve ekonomik önemi,” Kastamonu University Journal of Forestry Faculty, vol. 11, no. 1, pp. 52–67. https://izlik.org/JA42YU59AX
- Güner, A., Kandemir, A., Menemen, Y., Yıldırım, H., Aslan, S., Ekşi, G., Güner, I., and Çimen, A., (2014). “Resimli Türkiye Florası”.
- Carrick, J., (1976). “Studıes In Australıan Lamıaceae 1. The Genus Wrıxonıa F. Muell. (Prostantheroıdeae),” Journal of the Adelaide Botanic Garden. https://www.jstor.org/stable/23872061
- Skaltsa, H., Demetzos, C., Lazari, D., and Sokovic, M., (2003). “Essential oil analysis and antimicrobial activity of eight Stachys species from Greece,” Phytochemistry. https://doi.org/10.1016/S0031-9422(03)00386-8
- Akçay S., and Şengül, H., (2023). “A Study on Environmental Literacy of Middle School Students,” Necmettin Erbakan Üniversitesi Ahmet Keleşoğlu Eğitim Fakültesi Dergisi, vol. 5, no. 1, pp. 139–169. https://doi.org/10.38151/akef.2023.48
- Bahadori, M., B., Kirkan, B., and Sarıkürkçü, C., (2019). “Phenolic ingredients and therapeutic potential of Stachys cretica subsp. smyrnaea for the management of oxidative stress, Alzheimer’s disease,” Ind Crops Prod, vol. 127, pp. 82–87. https://doi.org/10.1016/j.indcrop.2018.10.066
- Bahadori, M., B., Kirkan, B., Sarıkürkçü C., and Ceylan, O., (2019). “Metabolite profiling and health benefits of Stachys cretica subsp. mersinaea as a medicinal food,” Ind Crops Prod, vol. 131, pp. 85–89. https://doi.org/10.1016/j.indcrop.2019.01.038
- Temel, M., Kargıoğlu, M., Arı, S., (2015). “Afyonkarahisar’da yayılış gösteren Stachys byzantina (Lamiaceae)’nın morfolojik, anatomik ve ekolojik özellikleri,” Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 10, no. 2, pp. 35–47. https://izlik.org/JA97EF62BN
- Topçu, G., (2019). “Chemical Diversity of Bioactive Diterpenoids of Endemic Anatolian Lamiaceae Plants,” Mesmap–5 Proceedings Book.
- Bhattacharjee, R., “Taxonomic studies in Stachys. II. A new infrageneric classification of Stachys L.,” Notes from the Royal Botanic Garden Edinburgh, 1980.