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SEİZURE TRİGGERED BY SUDDEN DİSCONTİNUATİON OF PREGABALİN: A CASE REPORT

Yıl 2026, Sayı: 5 , 254 - 259 , 26.03.2026
https://doi.org/10.70846/nigdetip.1813909
https://izlik.org/JA87DX88AA

Öz

Pregabalin is currently used in the treatment of pain, anxiety disorders and partial seizures. Pregabalin also has a relaxing and euphoric effect. For this reason, it is frequently abused. There is no definitive guideline for the treatment of pregabalin addiction. This case describes the emergence of an epileptic seizure in a healthy adult with the sudden discontinuation of high-dose pregabalin in the treatment of pregabalin addiction. In the literature, no similar case has been reported.

Etik Beyan

Informed consent has been obtained from the patient.

Destekleyen Kurum

yok

Teşekkür

I would like to thank the participant for allowing the publication of the content.

Kaynakça

  • Baidya DK, Agarwal A, Khanna P, Arora MK. Pregabalin in acute and chronic pain. J Anaesthesiol Clin Pharmacol. 2011;27(3):307-314. doi:10.4103/0970-9185.83672
  • Grosshans M, Lemenager T, Vollmert C, Kaemmerer N, Schreiner R, Mutschler J, et al. Pregabalin abuse among opiate addicted patients. Eur J Clin Pharmacol. 2013;69(12):2021-2025. doi:10.1007/s00228-013-1578-5
  • Öztürk B, Bodur İ, Tekeli A, Akça Çağlar A, Karacan CD, Tuygun N. A new threat in adolescence: pregabalin abuse. J Behcet Uz Child Hosp. 2019;9(2):164-166. doi:10.5222/buchd.2019.164
  • Svalina T, Kokalj Palandacic A. Pregabalin abuse: a case report. Psychiatr Danub. 2021;33(Suppl 4):1238-1239. doi:10.24869/psyd.2021.1238
  • Gupta M, Singh J, Udey B. Very high dose of pregabalin abuse: a case report. Indian J Psychiatry. 2023;65(9):979-980. doi:10.4103/indianjpsychiatry.indianjpsychiatry_120_23
  • Oskouei Z, Moshiri M, Raouf-Rahmati A, Nemati A, Naeini MB, Jomehpour H, et al. Seizures as an adverse effect of pregabalin consumption: a systematic review. Addict Health. 2025;17:1527. doi:10.22122/ahj.v17i0.1527
  • Parekh M, Dash GK, Ahamed I. Pregabalin toxicity manifesting as reversible encephalopathy with continuous triphasic waves in electroencephalogram. Clin Neuropharmacol. 2017;40(5):226-228. doi:10.1097/WNF.0000000000000235
  • Isoardi KZ, Polkinghorne G, Harris K, Isbister GK. Pregabalin poisoning and rising recreational use: a retrospective observational series. Br J Clin Pharmacol. 2020;86(12):2435-2440. doi:10.1111/bcp.14318
  • Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. Abuse and misuse of pregabalin and gabapentin: a systematic review update. Drugs. 2021;81(1):125-156. doi:10.1007/s40265-020-01432-7
  • Hägg S, Jönsson AK, Ahlner J. Current evidence on abuse and misuse of gabapentinoids. Drug Saf. 2020;43(12):1235-1254. doi:10.1007/s40264-020-00979-8
  • Cross AL, Viswanath O, Sherman AL. Pregabalin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470341/
  • Kasper S, Iglesias-García C, Schweizer E, Wilson J, DuBrava S, Prieto R, et al. Pregabalin long-term treatment and assessment of discontinuation in patients with generalized anxiety disorder. Int J Neuropsychopharmacol. 2014;17(5):685-695. doi:10.1017/S1461145713001640
  • Braid JJ, Kirker SG, Baguley IJ. Spasticity increases during pregabalin withdrawal. Brain Inj. 2013;27(1):120-124. doi:10.3109/02699052.2012.722257
  • Ishikawa H, Takeshima M, Ishikawa H, Ayabe N, Ohta H, Mishima K. Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: a case series and literature review. Neuropsychopharmacol Rep. 2021;41(3):434-439. doi:10.1002/npr2.12197
  • Du YT, Roberts AP, Torpy DJ. Seizure induced by sudden cessation of pregabalin in a patient with chronic kidney disease. BMJ Case Rep. 2017;2017:bcr-2017-220374. doi:10.1136/bcr-2017-220374
  • Wellington K, Perry CM. Venlafaxine extended-release: a review of its use in the management of major depression. CNS Drugs. 2001;15(8):643-669. doi:10.2165/00023210-200115080-00005
  • Beghi E, Giussani G, Grosso S, Iudice A, La Neve A, Pisani F, et al. Withdrawal of antiepileptic drugs: guidelines of the Italian League Against Epilepsy. Epilepsia. 2013;54(Suppl 7):2-12. doi:10.1111/epi.12305

PREGABALİNİN ANİDEN KESİLMESİNİN TETİKLEDİĞİ NÖBET: BİR VAKA RAPORU

Yıl 2026, Sayı: 5 , 254 - 259 , 26.03.2026
https://doi.org/10.70846/nigdetip.1813909
https://izlik.org/JA87DX88AA

Öz

Pregabalin günümüzde ağrı, anksiyete bozuklukları ve parsiyel nöbetlerin tedavisinde kullanılmaktadır. Ayrıca pregabalinin rahatlatıcı ve öforik bir etkisi vardır. Bu nedenle sıklıkla kötüye kullanılır. Pregabalin bağımlılığının tedavisi için kesin bir kılavuz yoktur. Bu olgu sunumunda, pregabalin bağımlılığı tedavisinde hastanın kullandığı yüksek doz pregabalinin ani kesilmesi sonucu sağlıklı bir yetişkinde epileptik nöbet ortaya çıkması anlatılmaktadır. Literatürde benzer bir olguya rastlanılmamıştır.

Etik Beyan

Olgudan bilgilendirilmiş onam alınmıştır

Destekleyen Kurum

none

Teşekkür

Katılımcıya olgunun yayınlanmasına izin verdiği için teşekkür ederim.

Kaynakça

  • Baidya DK, Agarwal A, Khanna P, Arora MK. Pregabalin in acute and chronic pain. J Anaesthesiol Clin Pharmacol. 2011;27(3):307-314. doi:10.4103/0970-9185.83672
  • Grosshans M, Lemenager T, Vollmert C, Kaemmerer N, Schreiner R, Mutschler J, et al. Pregabalin abuse among opiate addicted patients. Eur J Clin Pharmacol. 2013;69(12):2021-2025. doi:10.1007/s00228-013-1578-5
  • Öztürk B, Bodur İ, Tekeli A, Akça Çağlar A, Karacan CD, Tuygun N. A new threat in adolescence: pregabalin abuse. J Behcet Uz Child Hosp. 2019;9(2):164-166. doi:10.5222/buchd.2019.164
  • Svalina T, Kokalj Palandacic A. Pregabalin abuse: a case report. Psychiatr Danub. 2021;33(Suppl 4):1238-1239. doi:10.24869/psyd.2021.1238
  • Gupta M, Singh J, Udey B. Very high dose of pregabalin abuse: a case report. Indian J Psychiatry. 2023;65(9):979-980. doi:10.4103/indianjpsychiatry.indianjpsychiatry_120_23
  • Oskouei Z, Moshiri M, Raouf-Rahmati A, Nemati A, Naeini MB, Jomehpour H, et al. Seizures as an adverse effect of pregabalin consumption: a systematic review. Addict Health. 2025;17:1527. doi:10.22122/ahj.v17i0.1527
  • Parekh M, Dash GK, Ahamed I. Pregabalin toxicity manifesting as reversible encephalopathy with continuous triphasic waves in electroencephalogram. Clin Neuropharmacol. 2017;40(5):226-228. doi:10.1097/WNF.0000000000000235
  • Isoardi KZ, Polkinghorne G, Harris K, Isbister GK. Pregabalin poisoning and rising recreational use: a retrospective observational series. Br J Clin Pharmacol. 2020;86(12):2435-2440. doi:10.1111/bcp.14318
  • Evoy KE, Sadrameli S, Contreras J, Covvey JR, Peckham AM, Morrison MD. Abuse and misuse of pregabalin and gabapentin: a systematic review update. Drugs. 2021;81(1):125-156. doi:10.1007/s40265-020-01432-7
  • Hägg S, Jönsson AK, Ahlner J. Current evidence on abuse and misuse of gabapentinoids. Drug Saf. 2020;43(12):1235-1254. doi:10.1007/s40264-020-00979-8
  • Cross AL, Viswanath O, Sherman AL. Pregabalin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470341/
  • Kasper S, Iglesias-García C, Schweizer E, Wilson J, DuBrava S, Prieto R, et al. Pregabalin long-term treatment and assessment of discontinuation in patients with generalized anxiety disorder. Int J Neuropsychopharmacol. 2014;17(5):685-695. doi:10.1017/S1461145713001640
  • Braid JJ, Kirker SG, Baguley IJ. Spasticity increases during pregabalin withdrawal. Brain Inj. 2013;27(1):120-124. doi:10.3109/02699052.2012.722257
  • Ishikawa H, Takeshima M, Ishikawa H, Ayabe N, Ohta H, Mishima K. Pregabalin withdrawal in patients without psychiatric disorders taking a regular dose of pregabalin: a case series and literature review. Neuropsychopharmacol Rep. 2021;41(3):434-439. doi:10.1002/npr2.12197
  • Du YT, Roberts AP, Torpy DJ. Seizure induced by sudden cessation of pregabalin in a patient with chronic kidney disease. BMJ Case Rep. 2017;2017:bcr-2017-220374. doi:10.1136/bcr-2017-220374
  • Wellington K, Perry CM. Venlafaxine extended-release: a review of its use in the management of major depression. CNS Drugs. 2001;15(8):643-669. doi:10.2165/00023210-200115080-00005
  • Beghi E, Giussani G, Grosso S, Iudice A, La Neve A, Pisani F, et al. Withdrawal of antiepileptic drugs: guidelines of the Italian League Against Epilepsy. Epilepsia. 2013;54(Suppl 7):2-12. doi:10.1111/epi.12305
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Psikiyatri
Bölüm Olgu Sunumu
Yazarlar

İlknur Gündoğdu 0000-0003-0401-8622

Gönderilme Tarihi 30 Ekim 2025
Kabul Tarihi 9 Aralık 2025
Yayımlanma Tarihi 26 Mart 2026
DOI https://doi.org/10.70846/nigdetip.1813909
IZ https://izlik.org/JA87DX88AA
Yayımlandığı Sayı Yıl 2026 Sayı: 5

Kaynak Göster

Vancouver 1.İlknur Gündoğdu. SEİZURE TRİGGERED BY SUDDEN DİSCONTİNUATİON OF PREGABALİN: A CASE REPORT. Niğde Tıp Dergisi. 01 Mart 2026;(5):254-9. doi:10.70846/nigdetip.1813909