Akut Bronşiolit Tanılı İnfantlarda Ortalama Platelet Hacmi, İkisi Arasında Bir Korelasyon Var Mı?

Öz

Akut bronşiolit, 2 yaş altı çocuklarda en sık görülen alt solunum yolu enfeksiyonudur. Tanı klinik olarak konmasına rağmen, tanı koymak ve tedavi için önemli olan hastalık ciddiyetini değerlendirmek için standart kriterler bulunmamaktadır. Son yıllarda yapılan çalışmalarda ortalama trombosit hacmi (MPV) değerinin akut faz reaktanı olarak kullanılabileceği öne sürülmüştür. Lokal inflamasyon ile ilişkisi gösterilmesine rağmen MPV ve akut bronşiolit ilişkisini gösteren az sayıda çalışma bulunmaktadır. Biz de çalışmamızda MPV ve bronşiolit arasındaki ilişkiyi araştırmak ve MPV'nin hastalık ciddiyetini göstermede faydalı bir parametre olarak kullanılıp kullanılamayacağını değerlendirmek istedik. Bu retrospektif çalışmada 555 akut bronşiolit hastası ve aynı yaş ve cinsiyete sahip 516 sağlıklı hasta çalışmaya dahil edildi. MPV düzeyleri hasta grubunda (8,2 fl), hasta grubuna göre (7,8) anlamlı olarak yüksek saptandı. Ancak hastane yatışı gerektiren ve ayaktan tedavi alan hastalar arasında anlamlı bir fark saptanamadı. Sonuç olarak MPV değeri akut bronşiolit hastalarında artmakta ancak, hastaneye yatış, yoğun bakım ve sterod ihtiyacını öngörememektedir. 

Anahtar Kelimeler

• Platelet,bronşiolit,MPV,çocuklar

Mean Platelet Volumes Of Infants Wİth Acute Bronchıolıtıs, is There a Correlation Between Them?

Abstract

Acute bronchiolitis is the most common lower respiratory tract infection of children younger than 2 years of age. Although the diagnose is clinical and the severity plays an important role in treatment, there aren't any standardized diagnostic criterias and severity assessment classifications for acute bronchiolitis available in literature. Results of the recent studies suggest that one of the platelet activation indice, MPV, can be used as an acute phase reactant in diseases. MPV has shown to be effected in local inflammations and to our knowledge there's only one recent study in children with acute bronchiolitis that demonstrates a decrease in MPV. Therefore more studies are needed to clarify the relation between MPV and acute bronchiolitis. In this present study we aim to determine the association between MPV and acute bronchiolitis, also identify whether it’s a useful marker on assessing disease severity or not. In this retrospective study we enrolled 555 children diagnosed with Acute bronchiolitis and 516 healthy infants with a matching age and sex. MPV levels were found significantly higher in patient group (8,2 ± 0,8 fL) than the control group (7,9 ± 0,8 fL).  In terms of hospitalization need no significant difference detected between the MPV values of hospitalized group and outpatients, 8,3±0,8 fL; 8,2±0.7 fL respectively. In conclusion, our data show that MPV values significantly elevate in acute bronchiolitis compared to healthy infants. However, MPV can't be used as a guidance in attack severity nor can predict hospitalization, PICU admittion, and systemic steroid need.

Keywords

• Platelets,bronchiolitis,children,mpv

Kaynakça

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