Aurasız Migrenli Hastalarda Oksidatif Stres Parametreleri

Öz

Amaç: Önceki araştırmalar, migrenin oksidatif strese karşı artan hassasiyet ile ilişkili olabileceğini ileri sürmüştür. Bu çalışmanın amacı, aurasız migren hastalarında serum paraoksonaz ve arilesteraz aktiviteleri, tiyol düzeyleri, iskemi-modifiye albümin, total oksidan durum, total antioksidan durum ve oksidatif stres indeksini araştırmaktır.

Materyal ve Metot: Aurasız migrenli 30 hasta (5 erkek ve 25 kadın) ve 30 sağlıklı kontrol (8 erkek ve 22 kadın) çalışmaya dahil edildi. Spektrofotometrik yöntemle serum paraoksonaz ve arilesteraz aktiviteleri, tiyol düzeyleri, iskemi-modifiye albümin, total antioksidan durum, total oksidan durum ve oksidatif stres indeksi belirlendi. İstatistiksel analiz Mann-Whitney U testi ve bağımsız örneklem t-testi kullanılarak yapıldı ve p <0.05 istatistiksel olarak anlamlı kabul edildi.

Bulgular: Paraoksonaz ve arilesteraz düzeyleri kontrol grubuna göre aurasız migren grubunda anlamlı derecede düşük bulundu (p <0.05).

Sonuçlar:  Bulgularımız paraoksonaz ve arilesteraz düzeylerinin aurasız migren ile ilişkili olabileceğini düşündürmektedir. Migren hastalarında oksidatif stress belirteçlerinin daha büyük bir popülasyona sahip ve bu parametreler dikkate alınarak araştırılması önerilir.

Anahtar Kelimeler

• Migren,Oksidatif stres,Aurasız

OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH MIGRAINE WITHOUT AURA

Abstract

Objective: Previous research has suggested that migraine may be associated with increased vulnerability to oxidative stress. The purpose of this study was to evaluate serum paraoxonase and arylesterase  activities, thiols levels, ischemia-modified albumin, the total oxidant status, total antioxidant status, and oxidative stress index  in patients with migraine without aura.

Material and Methods: 30 patients (5 males and 25 females) and 30 matched healthy controls (8 males and 22 females) were enrolled. Serum paraoxonase and arylesterase activities, thiols levels, ischemia-modified albumin, total antioxidant status, total oxidant status and oxidative stress index were determined by using the spectrophotometric method. Statistical analysis was conducted using Mann–Whitney U test and independent samples t-test, and p <0.05  was considered as statistically significant.

Results: Paraoxonase and arylesterase  levels were significantly lower in the migraine without aura group compared with the control group (p <0.05).

Conclusion: Our findings suggested that the paraoxonase and arylesterase levels might be associated with migraine without aura. In migraine patients, it is recommended that oxidative stress markers be investigated with a larger population and these parameters are taken into consideration.

Keywords

• Migraine,Oxidative stress,Without aura

Kaynakça

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